Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.)
Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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MDPI
2020
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| Online Access: | https://hdl.handle.net/10568/109550 |
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| author | Panda, S.K. Castro, A.H.F. Jouneghani, R.S. Leyssen, P. Neyts, J. Swennen, Rony L. Luyten, W. |
| author_browse | Castro, A.H.F. Jouneghani, R.S. Leyssen, P. Luyten, W. Neyts, J. Panda, S.K. Swennen, Rony L. |
| author_facet | Panda, S.K. Castro, A.H.F. Jouneghani, R.S. Leyssen, P. Neyts, J. Swennen, Rony L. Luyten, W. |
| author_sort | Panda, S.K. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (EV71), and yellow fever virus (YFV). Extracts prepared with acetone and ethanol from leaf parts of several cultivars exhibited strong (EC50 around 10 μg/mL) anti-CHIKV activity. Interestingly, none of the banana plant extracts (concentration 1–100 µg/mL) were active against EV71. Activity against YFV was restricted to two cultivars: Namwa Khom–Pseudostem–Ethanol (5.9 ± 5.4), Namwa Khom–Corm–Ethanol (0.79 ± 0.1) and Fougamou–Corm–Acetone (2.5 ± 1.5). In most cases, the cytotoxic activity of the extracts was generally 5- to 10-fold lower than the antiviral activity, suggesting a reasonable therapeutic window. |
| format | Journal Article |
| id | CGSpace109550 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1095502025-11-11T17:41:16Z Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) Panda, S.K. Castro, A.H.F. Jouneghani, R.S. Leyssen, P. Neyts, J. Swennen, Rony L. Luyten, W. bananas chikungunya virus cytotoxicity enterovirus plant diseases cultivars yellow fever antiviral agents virology infectious diseases Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (EV71), and yellow fever virus (YFV). Extracts prepared with acetone and ethanol from leaf parts of several cultivars exhibited strong (EC50 around 10 μg/mL) anti-CHIKV activity. Interestingly, none of the banana plant extracts (concentration 1–100 µg/mL) were active against EV71. Activity against YFV was restricted to two cultivars: Namwa Khom–Pseudostem–Ethanol (5.9 ± 5.4), Namwa Khom–Corm–Ethanol (0.79 ± 0.1) and Fougamou–Corm–Acetone (2.5 ± 1.5). In most cases, the cytotoxic activity of the extracts was generally 5- to 10-fold lower than the antiviral activity, suggesting a reasonable therapeutic window. 2020 2020-09-21T10:06:07Z 2020-09-21T10:06:07Z Journal Article https://hdl.handle.net/10568/109550 en Open Access application/pdf MDPI Panda, S.K., Castro, A.H.F., Jouneghani, R.S., Leyssen, P., Neyts, J., Swennen, R. & Luyten, W. (2020). Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.). Viruses, 12(5), 549: 1-17. |
| spellingShingle | bananas chikungunya virus cytotoxicity enterovirus plant diseases cultivars yellow fever antiviral agents virology infectious diseases Panda, S.K. Castro, A.H.F. Jouneghani, R.S. Leyssen, P. Neyts, J. Swennen, Rony L. Luyten, W. Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title | Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title_full | Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title_fullStr | Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title_full_unstemmed | Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title_short | Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.) |
| title_sort | antiviral and cytotoxic activity of different plant parts of banana musa spp |
| topic | bananas chikungunya virus cytotoxicity enterovirus plant diseases cultivars yellow fever antiviral agents virology infectious diseases |
| url | https://hdl.handle.net/10568/109550 |
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