Variant antigen diversity in Trypanosoma vivax is not driven by recombination
African trypanosomes (Trypanosoma) are vector-borne haemoparasites that survive in the vertebrate bloodstream through antigenic variation of their Variant Surface Glycoprotein (VSG). Recombination, or rather segmented gene conversion, is fundamental in Trypanosoma brucei for both VSG gene switching...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Springer
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/109528 |
| _version_ | 1855529368780013568 |
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| author | Pereira, S.S. Neto, K.J.G.A.C. Duffy, C.W. Richards, P. Noyes, H. Ogugo, Moses André, M.R. Bengaly, Z. Kemp, Stephen J. Teixeira, M.M.G. Machado, R.Z. Jackson, A.P. |
| author_browse | André, M.R. Bengaly, Z. Duffy, C.W. Jackson, A.P. Kemp, Stephen J. Machado, R.Z. Neto, K.J.G.A.C. Noyes, H. Ogugo, Moses Pereira, S.S. Richards, P. Teixeira, M.M.G. |
| author_facet | Pereira, S.S. Neto, K.J.G.A.C. Duffy, C.W. Richards, P. Noyes, H. Ogugo, Moses André, M.R. Bengaly, Z. Kemp, Stephen J. Teixeira, M.M.G. Machado, R.Z. Jackson, A.P. |
| author_sort | Pereira, S.S. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | African trypanosomes (Trypanosoma) are vector-borne haemoparasites that survive in the vertebrate bloodstream through antigenic variation of their Variant Surface Glycoprotein (VSG). Recombination, or rather segmented gene conversion, is fundamental in Trypanosoma brucei for both VSG gene switching and for generating antigenic diversity during infections. Trypanosoma vivax is a related, livestock pathogen whose VSG lack structures that facilitate gene conversion in T. brucei and mechanisms underlying its antigenic diversity are poorly understood. Here we show that species-wide VSG repertoire is broadly conserved across diverse T. vivax clinical strains and has limited antigenic repertoire. We use variant antigen profiling, coalescent approaches and experimental infections to show that recombination plays little role in diversifying T. vivax VSG sequences. These results have immediate consequences for both the current mechanistic model of antigenic variation in African trypanosomes and species differences in virulence and transmission, requiring reconsideration of the wider epidemiology of animal African trypanosomiasis. |
| format | Journal Article |
| id | CGSpace109528 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1095282025-12-08T09:54:28Z Variant antigen diversity in Trypanosoma vivax is not driven by recombination Pereira, S.S. Neto, K.J.G.A.C. Duffy, C.W. Richards, P. Noyes, H. Ogugo, Moses André, M.R. Bengaly, Z. Kemp, Stephen J. Teixeira, M.M.G. Machado, R.Z. Jackson, A.P. animal diseases epidemiology trypanosomiasis genetics livestock vaccines African trypanosomes (Trypanosoma) are vector-borne haemoparasites that survive in the vertebrate bloodstream through antigenic variation of their Variant Surface Glycoprotein (VSG). Recombination, or rather segmented gene conversion, is fundamental in Trypanosoma brucei for both VSG gene switching and for generating antigenic diversity during infections. Trypanosoma vivax is a related, livestock pathogen whose VSG lack structures that facilitate gene conversion in T. brucei and mechanisms underlying its antigenic diversity are poorly understood. Here we show that species-wide VSG repertoire is broadly conserved across diverse T. vivax clinical strains and has limited antigenic repertoire. We use variant antigen profiling, coalescent approaches and experimental infections to show that recombination plays little role in diversifying T. vivax VSG sequences. These results have immediate consequences for both the current mechanistic model of antigenic variation in African trypanosomes and species differences in virulence and transmission, requiring reconsideration of the wider epidemiology of animal African trypanosomiasis. 2020-02-12 2020-09-17T11:04:36Z 2020-09-17T11:04:36Z Journal Article https://hdl.handle.net/10568/109528 en Open Access Springer Pereira, S.S., Neto, K.J.G.A.C., Duffy, C.W., Richards, P., Noyes, H., Ogugo, M., André, M.R., Bengaly, Z., Kemp, S., Teixeira, M.M.G., Machado, R.Z. and Jackson, A.P. 2020. Variant antigen diversity in Trypanosoma vivax is not driven by recombination. Nature Communications 11:844. |
| spellingShingle | animal diseases epidemiology trypanosomiasis genetics livestock vaccines Pereira, S.S. Neto, K.J.G.A.C. Duffy, C.W. Richards, P. Noyes, H. Ogugo, Moses André, M.R. Bengaly, Z. Kemp, Stephen J. Teixeira, M.M.G. Machado, R.Z. Jackson, A.P. Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title | Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title_full | Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title_fullStr | Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title_full_unstemmed | Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title_short | Variant antigen diversity in Trypanosoma vivax is not driven by recombination |
| title_sort | variant antigen diversity in trypanosoma vivax is not driven by recombination |
| topic | animal diseases epidemiology trypanosomiasis genetics livestock vaccines |
| url | https://hdl.handle.net/10568/109528 |
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