Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms
Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57%...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2020
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/109370 |
| _version_ | 1855535959147282432 |
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| author | Subudhi, A.K. O’Donnell, A.J. Ramaprasad, A. Abkallo, Hussein M. Kaushik, A. Ansari, H.R. Abdel-Haleem, A.M. Rached, F.B. Kaneko, O. Culleton, R. Reece, S.E. Pain, A. |
| author_browse | Abdel-Haleem, A.M. Abkallo, Hussein M. Ansari, H.R. Culleton, R. Kaneko, O. Kaushik, A. O’Donnell, A.J. Pain, A. Rached, F.B. Ramaprasad, A. Reece, S.E. Subudhi, A.K. |
| author_facet | Subudhi, A.K. O’Donnell, A.J. Ramaprasad, A. Abkallo, Hussein M. Kaushik, A. Ansari, H.R. Abdel-Haleem, A.M. Rached, F.B. Kaneko, O. Culleton, R. Reece, S.E. Pain, A. |
| author_sort | Subudhi, A.K. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24 h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24 h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms. |
| format | Journal Article |
| id | CGSpace109370 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1093702024-05-01T08:19:02Z Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms Subudhi, A.K. O’Donnell, A.J. Ramaprasad, A. Abkallo, Hussein M. Kaushik, A. Ansari, H.R. Abdel-Haleem, A.M. Rached, F.B. Kaneko, O. Culleton, R. Reece, S.E. Pain, A. malaria parasites Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24 h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24 h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms. 2020-06-02 2020-09-08T15:09:39Z 2020-09-08T15:09:39Z Journal Article https://hdl.handle.net/10568/109370 en Open Access Springer Subudhi, A.K., O’Donnell, A.J., Ramaprasad, A., Abkallo, H.M., Kaushik, A., Ansari, H.R., Abdel-Haleem, A.M., Rached, F.B., Kaneko, O., Culleton, R., Reece, S.E. and Pain, A. 2020. Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms. Nature Communications 11: 2763. |
| spellingShingle | malaria parasites Subudhi, A.K. O’Donnell, A.J. Ramaprasad, A. Abkallo, Hussein M. Kaushik, A. Ansari, H.R. Abdel-Haleem, A.M. Rached, F.B. Kaneko, O. Culleton, R. Reece, S.E. Pain, A. Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title | Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title_full | Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title_fullStr | Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title_full_unstemmed | Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title_short | Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| title_sort | malaria parasites regulate intra erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms |
| topic | malaria parasites |
| url | https://hdl.handle.net/10568/109370 |
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