Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam
(1) Background: Burkholderia pseudomallei is an environmentally mediated saprophytic pathogen that can cause severe disease in humans. It is well known that B. pseudomallei survives in tropical moist soil environments worldwide, but melioidosis is gaining recognition as a public and veterinary healt...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/109208 |
| _version_ | 1855527841404289024 |
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| author | Norris, M.H. Hang Thi Thu Tran Walker, M.A. Bluhm, A.P. Zincke, D. Trinh Thanh Trung Nga Vu Thi Ngoc Pham Thi Schweizer, H.P. Unger, Fred Blackburn, J.K. Nguyen Thi Thu Hang |
| author_browse | Blackburn, J.K. Bluhm, A.P. Hang Thi Thu Tran Nga Vu Thi Ngoc Pham Thi Nguyen Thi Thu Hang Norris, M.H. Schweizer, H.P. Trinh Thanh Trung Unger, Fred Walker, M.A. Zincke, D. |
| author_facet | Norris, M.H. Hang Thi Thu Tran Walker, M.A. Bluhm, A.P. Zincke, D. Trinh Thanh Trung Nga Vu Thi Ngoc Pham Thi Schweizer, H.P. Unger, Fred Blackburn, J.K. Nguyen Thi Thu Hang |
| author_sort | Norris, M.H. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | (1) Background: Burkholderia pseudomallei is an environmentally mediated saprophytic pathogen that can cause severe disease in humans. It is well known that B. pseudomallei survives in tropical moist soil environments worldwide, but melioidosis is gaining recognition as a public and veterinary health issue in Vietnam. The contribution of animals to human disease is unknown, necessitating further investigation. (2) Methods: Swine sera were collected from two populations, one grazing and one commercially farmed, from three provinces in Vietnam. ELISAs utilizing B. pseudomallei capsular polysaccharide (CPS), outer polysaccharide (OPS), and Hcp1 protein were used to screen serum samples. Positive samples were mapped to the commune level. Seroprevalence calculations and pig population estimates were used to approximate number of swine exposures per commune. (3) Results: Grazing pigs from Hoa Binh had significantly higher seropositivity levels (11.4%, 95% CI: 9.7–13.1) compared to farmed pigs from Ha Tinh and Nghe An (4%, 95% CI: 3.3–4.7). Average swine seropositivity rates were ~6.3% (95% CI: 5–7.9), higher than previously identified in Vietnam (~0.88%). (4) Conclusions: Initial serological sampling identified a significant number of seropositive and potential melioidosis infections occurring in swine in Vietnam. This work is a critical step in understanding the role swine may play in the epidemiology of human melioidosis in Vietnam. |
| format | Journal Article |
| id | CGSpace109208 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1092082023-12-08T19:36:04Z Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam Norris, M.H. Hang Thi Thu Tran Walker, M.A. Bluhm, A.P. Zincke, D. Trinh Thanh Trung Nga Vu Thi Ngoc Pham Thi Schweizer, H.P. Unger, Fred Blackburn, J.K. Nguyen Thi Thu Hang swine animal diseases zoonoses (1) Background: Burkholderia pseudomallei is an environmentally mediated saprophytic pathogen that can cause severe disease in humans. It is well known that B. pseudomallei survives in tropical moist soil environments worldwide, but melioidosis is gaining recognition as a public and veterinary health issue in Vietnam. The contribution of animals to human disease is unknown, necessitating further investigation. (2) Methods: Swine sera were collected from two populations, one grazing and one commercially farmed, from three provinces in Vietnam. ELISAs utilizing B. pseudomallei capsular polysaccharide (CPS), outer polysaccharide (OPS), and Hcp1 protein were used to screen serum samples. Positive samples were mapped to the commune level. Seroprevalence calculations and pig population estimates were used to approximate number of swine exposures per commune. (3) Results: Grazing pigs from Hoa Binh had significantly higher seropositivity levels (11.4%, 95% CI: 9.7–13.1) compared to farmed pigs from Ha Tinh and Nghe An (4%, 95% CI: 3.3–4.7). Average swine seropositivity rates were ~6.3% (95% CI: 5–7.9), higher than previously identified in Vietnam (~0.88%). (4) Conclusions: Initial serological sampling identified a significant number of seropositive and potential melioidosis infections occurring in swine in Vietnam. This work is a critical step in understanding the role swine may play in the epidemiology of human melioidosis in Vietnam. 2020-07-18 2020-09-04T07:12:19Z 2020-09-04T07:12:19Z Journal Article https://hdl.handle.net/10568/109208 en Open Access MDPI Norris, M.H., Hang Thi Thu Tran, Walker, M.A., Bluhm, A.P., Zincke, D., Trinh Thanh Trung, Nga Vu Thi, Ngoc Pham Thi, Schweizer, H.P., Unger, F., Blackburn, J.K. and Nguyen Thi Thu Hang. 2020. Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam. International Journal of Environmental Research and Public Health 17(14): 5203. |
| spellingShingle | swine animal diseases zoonoses Norris, M.H. Hang Thi Thu Tran Walker, M.A. Bluhm, A.P. Zincke, D. Trinh Thanh Trung Nga Vu Thi Ngoc Pham Thi Schweizer, H.P. Unger, Fred Blackburn, J.K. Nguyen Thi Thu Hang Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title | Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title_full | Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title_fullStr | Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title_full_unstemmed | Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title_short | Distribution of serological response to Burkholderia pseudomallei in swine from three provinces of Vietnam |
| title_sort | distribution of serological response to burkholderia pseudomallei in swine from three provinces of vietnam |
| topic | swine animal diseases zoonoses |
| url | https://hdl.handle.net/10568/109208 |
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