Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)
Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains po...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2019
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/107976 |
| _version_ | 1855514535714095104 |
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| author | Dolebo, Asrat T. Khayatzadeh, Negar Melesse, Aberra Wragg, David Rekik, Mourad Haile, Aynalem Rischkowsky, Barbara A. Rothschild, Max F. Mwacharo, Joram M. |
| author_browse | Dolebo, Asrat T. Haile, Aynalem Khayatzadeh, Negar Melesse, Aberra Mwacharo, Joram M. Rekik, Mourad Rischkowsky, Barbara A. Rothschild, Max F. Wragg, David |
| author_facet | Dolebo, Asrat T. Khayatzadeh, Negar Melesse, Aberra Wragg, David Rekik, Mourad Haile, Aynalem Rischkowsky, Barbara A. Rothschild, Max F. Mwacharo, Joram M. |
| author_sort | Dolebo, Asrat T. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanningBMP15, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits includedSPOCK1(age at first oestrus),GPR173(mediator of ovarian cyclicity),HB-EGF(signalling early pregnancy success) andSMARCAL1andHMGN3a(regulate gene expression during embryogenesis). The genes involved in male reproduction wereFOXJ1(sperm function and successful fertilization) andNME5(spermatogenesis). We also observed genes such asPKD2L2,MAGED1andKDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control ofBMP15while other genes that enhance male and female fertility are essential for reproductive fitness. |
| format | Journal Article |
| id | CGSpace107976 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1079762023-12-08T19:36:04Z Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) Dolebo, Asrat T. Khayatzadeh, Negar Melesse, Aberra Wragg, David Rekik, Mourad Haile, Aynalem Rischkowsky, Barbara A. Rothschild, Max F. Mwacharo, Joram M. animal breeding breeds sheep small ruminants genetics indigenous breeds Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanningBMP15, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits includedSPOCK1(age at first oestrus),GPR173(mediator of ovarian cyclicity),HB-EGF(signalling early pregnancy success) andSMARCAL1andHMGN3a(regulate gene expression during embryogenesis). The genes involved in male reproduction wereFOXJ1(sperm function and successful fertilization) andNME5(spermatogenesis). We also observed genes such asPKD2L2,MAGED1andKDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control ofBMP15while other genes that enhance male and female fertility are essential for reproductive fitness. 2019-12 2020-04-14T07:41:41Z 2020-04-14T07:41:41Z Journal Article https://hdl.handle.net/10568/107976 en Open Access Springer Dolebo, A.T., Khayatzadeh, N., Melesse, A., Wragg, D.,· Rekik, M., Haile, A., Rischkowsky, B., Rothschild, M.F. and Mwacharo, J.M. 2019. Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries). Mammalian Genome 30:339–352. |
| spellingShingle | animal breeding breeds sheep small ruminants genetics indigenous breeds Dolebo, Asrat T. Khayatzadeh, Negar Melesse, Aberra Wragg, David Rekik, Mourad Haile, Aynalem Rischkowsky, Barbara A. Rothschild, Max F. Mwacharo, Joram M. Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title | Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title_full | Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title_fullStr | Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title_full_unstemmed | Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title_short | Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) |
| title_sort | genome wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub saharan african indigenous sheep ovis aries |
| topic | animal breeding breeds sheep small ruminants genetics indigenous breeds |
| url | https://hdl.handle.net/10568/107976 |
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