Resultados de búsqueda - "drug resistance"

Development and evaluation of an enzyme-linked immunosorbent assay (ELISA) for the determination of the trypanocidal drug homidium in serum of treated cattle por Murilla, G., Eisler, M.C., Peregrine, A.S., Ndung'u, J.M., Holmes, P.H.

“…The level of sensitivity afforded by these assays makes them potentially useful tools in the pharmacokinetic evaluation of homidium and for invetigating drug resistance or causes of drug failure. Assay 2 was chosen as being most suitable for further studies.…”
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Mapping genes for resistance to gastrointestinal nematodes por Behnke, J.M., Lowe, A., Menge, M., Iraqi, F.A., Wakelin, D.

“…Anthelmintic efficacy is decreasing as drug resistance becomes widespread and other approaches are needed. …”
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Collective livestock research for sustainable disease management in Mali and Burkina Faso por Liebenehm, S., Affognon, Hippolyte D., Waibel, H.

“…An international multi-disciplinary team of scientists, led by the International Livestock Research Institute (ILRI), tackled the problem of bovine trypanosomosis and the development of drug resistance in West Africa, inter alia, by the promotion of rational drug use (RDU) principles. …”
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya por Eisler, M.C., Maloo, S.H., Peregrine, A.S., Holmes, P.H., Thorpe, W.R.

“…It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the Development of drug-resistance in trypanosomes. A recently developed enzyme-linked immunosorbent assay (ELISA) for the detection of isometamidium provides a means of resolving this question in field situations. …”
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The antimicrobial resistance landscape of slaughterhouses in western Kenya: A microbiological case study por Hamilton, Katie A., Njoroge, Sam M., Momanyi, Kelvin, Murungi, Maurice K., Odinga, Christian O., Bor, Nicholas, Ogendo, Allan, Odaba, Josiah, Ogola, Joseph G., Fèvre, Eric M., Falzon, Laura C.

“…Bacterial isolates were identified in 101/193 (52.3 %) samples, and most showed resistance to streptomycin (68.7 %), ampicillin (48.7 %), and tetracycline (42.5 %). Multi drug resistance was exhibited by 35/80 isolates (43.8 %; 95 % CI: 33.2–54.9 %), while Extended Spectrum Beta Lactamase was expressed in 5/80 isolates (6.3 %; 95 % CI: 2.6–14.3 %). …”
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Genetics of disease resistance in small ruminants in Africa por Baker, R.L.

“…In Africa, many control strategies are limited by lack of efficient veterinary services, unavailability or high costs of drugs and vaccines, increasing occurrence of drug resistance by pathogens and limited scope to improve management cost-effectively. an attractive solution is to breed for disease resistance. …”
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Extravascular foci of Trypanosoma vivax in goats. The central nervous system and aqueous humor of the eye as potential sources of relapse infections after chemotherapy por Whitelaw, D.D., Gardiner, Peter R., Murray, M.

“…Relapse of parasitaemia after drug treatment of trypanosome infections is normally attributed to drug-resistance on the part of the parasite, under-dosage of the drug or reinfection of the host. …”
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Cross-resistance phenotypes associated with induction of resistance to isometamidium chloride and quinapyramine sulphate in Trypanosoma congolense por Peregrine, A.S., Kemei, S., Ndoutamia, G.

“…Furthermore, in some instances, multiple-drug resistance has been Reported and is a particular threat to livestock production. …”
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Single nucleotide polymorphisms may explain the contrasting phenotypes of two variants of a multidrug-resistant Mycobacterium tuberculosis strain por Bigi, María Mercedes, López, Beatriz, Blanco, Federico Carlos, Sasiain, María del Carmen, De La Barrera, Silvia Susana, Marti, Marcelo Adrián, Sosa, Ezequiel Jorge, Fernandez Do Porto, Darío Augusto, Ritacco, Viviana, Bigi, Fabiana, Soria, Marcelo Abel

“…Globally, about 4.5% of new tuberculosis (TB) cases are multi-drug-resistant (MDR), i.e. resistant to the two most powerful first-line anti-TB drugs. …”
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Some implications of a sexual cycle in theileria por Irvin, A.D., Boarer, C.D.H.

“…If these can be cloned and characterized by isoenzyme or drug resistance markers, then genetic recombinant studies, similar to those performed with malarial and coccidial parasites, could be conducted.The potential of genetic recombination greatly increases the scope of the parasite for developing new variants. …”
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Central nervous system involvement in goats undergoing primary infections with Trypanosoma brucei and relapse infections after chemotherapy por Whitelaw, D.D., Moulton, J.E., Morrison, W. Ivan, Murray, M.

“…Relapse of infection after trypanocidal drug treatment of trypanosome infections is normally attributed to drug resistance on the part of the parasite, under-dosage of the drug, or reinfection of the host. …”
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Drug combination of ciprofloxacin and polymyxin B for the treatment of multidrug-resistant Acinetobacter baumannii infections: A drug pair limiting the development of resistance por Wang, J., Stegger, M., Moodley, Arshnee, Yang, M.

“…This study suggests that inhalable spray–dried powders composed of the combination of CIP and PMB is promising for the treatment of respiratory infections caused by A. baumannii, and this combination can enhance the killing efficiency and suppress the development of drug resistance.…”
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Integrating nutrition security with treatment of people living with HIV: Lessons from Kenya por Bryan, Elizabeth, Gillespie, Stuart, Nangami, Mabel

“…The increased caloric requirements of HIV-positive individuals, undesirable side effects of treatment that may be worsened by malnutrition (but alleviated by nutritional support), and associated declines in adherence and possible increased drug resistance are all justifications for developing better interventions to strengthen the nutrition security of individuals receiving antiretroviral treatment. …”
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Petunia hybrida PDR2 is involved in herbivore defense by controlling steroidal contents in trichomes por Sasse, Joëlle, Schlegel, Markus, Borghi, Lorenzo, Ullrich, Friederike, Lee, Miyoung, Liu, Guo-Wei, Giner, José-Luis, Kayser, Oliver, Bigler, Laurent, Martinoia, Enrico, Kretzschmar, Tobias

“…Plant Pleiotropic Drug Resistance (PDR)‐type ABC transporters are known secondary metabolite transporters, and several have been implicated in pathogen or herbivore defense. …”
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Indigenous genetic resources: A sustainable and environmentally friendly option for livestock production in areas at risk from trypanosomosis por D'Ieteren, G.D.M., Kimani, K.

“…However, the efficacy of currently available trypanocidal drugs is also decreasing, due to drug resistance developing faster than generally thought. …”
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Host preference of tsetse: An important tool to appraise the Nagana risk of cattle in the cotton zone of Mali por Hoppenheit, A., Steuber, S., Bauer, B., Ouma, E.M., Diall, O., Zessin, K.H., Clausen, Peter-Henning

“…Nagana is routinely controlled by the use of trypanocides and an overreliance on their use throughout past decades resulted in multiple drug resistance of trypanosomes in most parts of West Africa's cotton belt. …”
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Trypanosomosis: A priority disease in tsetse-challenged areas of Burkina Faso por Soudre, A., Ouédraogo-Koné, S., Wurzinger, Maria, Muller, S., Hanotte, Olivier H., Ouédraogo, A.G., Sölkner, Johann

“…Trypanocidal drug quality and drug resistance were raised as a major concern by 30.77 and 50 % of the respondents, respectively. …”
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Economic benefits to farmers of six years of application of an insecticidal 'pour-on' to control tsetse in Ghibe, southwest Ethiopia por Mulatu, W., Swallow, B.M., Rowlands, G.J., Leak, S.G.A., D'Ieteren, G.D.M., Nagda, S.M.

“…Despite very high levels of drug resistance, trypanosomal prevalence in adult cattle has been reduced from 41 percent to 16 percent (a reduction of 61 percent) and the number of curative trypanocidal treatments per animal has been reduced by 50 percent. …”
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Prevalence and antimicrobial resistance of Salmonella isolated from carcasses, processing facilities and the environment surrounding small scale poultry slaughterhouses in Thailand por Chotinun, S., Rojanasthien, S., Unger, Fred, Tadee, P., Patchanee, P.

“…Antimicrobial susceptibility tests revealed that 68.4% of the Salmonella spp were resistant to at least one antimicrobial while 50.6% showed multiple drug resistance (MDR). Specifically, 44.3% of Salmonella were resistant to nalidixic acid, followed by streptomycin (41.8%), ampicillin (34.2%), tetracycline (34.2%), and sulfamethoxazole/trimethoprim (20.3%). …”
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Antimicrobial resistance analysis of non-typhoidal Salmonella in porcine from northern Vietnam por Clark, E.

“…Due to overcrowded hospitals and a lack of adequate diagnostic testing, Vietnam is a hotspot for drug resistance. Pork accounts for over 70% of total meat consumed within Vietnam, and contamination with NTS remains high. …”
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