Resultados de búsqueda - "Drugs development"

Plasmodium possesses dynein light chain classes that are unique and conserved across species por Githui, E.G., Villiers, Etienne P. de, McArthur, A.G.

“…This sequence variation could be targeted for vaccine or drug development.…”
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Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design por Lu, Stephen, Ascencio, Mariano, Torquato, Ricardo J.S., Florin-Christensen, Mónica, Tanaka, Aparecida S.

“…C1A cysteine peptidases have been shown to play an important role during apicomplexan invasion and egress of host red blood cells (RBCs) and therefore have been exploited as targets for drug development, in which peptidase specificity is deterministic. …”
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Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect por Bermejo, Almudena, Collado, Aida, Barrachina, Isabel, Marqués, Patrice, El Aouad, Noureddine, Franck, Xavier, Garibotto, Francisco, Dacquet, Catherine, Caignard, Daniel H., Suvire, Fernando D., Enriz, Ricardo D., Piqueras, Laura, Figadère, Bruno, Sanz, María-Jesús, Cabedo, Nuria, Cortés, Diego

“…We investigated the potential dual PPARα/γ agonism of prenylated benzopyrans polycerasoidol (1) and polycerasoidin (2) and their derivatives for novel drug development. Nine semisynthetic derivatives were prepared from the natural polycerasoidol (1) and polycerasoidin (2), which were evaluated for PPARα, -γ, -δ and retinoid X receptor-α activity in transactivation assays. …”
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Evaluation of cytotoxicity assays and a high-througput variant of the alkaline Comet assay in mouse lymphoma L5178Y cells por Gustavsson, Linda

“…The Comet assay, or Single Cell Gel Electrophoresis Assay, is a fast, easy and relatively inexpensive method to visualize and measure DNA strand breaks in individual cells. In the early drug development, when the amount of the test substance is limited, the Comet assay must fulfil several criteria. …”

Spatio-temporal mutational profile appearances of Swedish SARS-CoV-2 during the early pandemic por Ling, J., Hickman, R.A., Li, J., Lu, X., Lindahl, Johanna F., Lundkvist, Å., Järhult, J.D.

“…Characterization of these viral variants can provide precious insights on viral pathogenesis and can be valuable for diagnostic and drug development approaches.…”
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Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax por Versees, W., Decanniere, K., Pelle, Roger, Depoorter, J., Brosens, E., Parkin, D.W., Steyaert, J.

“…The purine salvage pathway of parasitic protozoa is currently considered as a target for drug development because these organisms cannot synthesize purines de novo. …”
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MicroRNA analysis of Taenia crassiceps cysticerci under praziquantel treatment and genome-wide identification of Taenia solium miRNAs por Pérez, Matías, Macchiaroli, Natalia, Lichtenstein, Gabriel, Conti, Gabriela, Asurmendi, Sebastian, Milone, Diego Humberto, Stegmayer, Georgina, Kamenetzky, Laura, Cucher, Marcela, Rosenzvit, Mara Cecilia

“…The results of our work could be applied to drug development and provide basic knowledge of cysticercosis and other neglected helminth infections.…”
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Characterization of a papain-like cysteine protease essential for the survival of Babesia ovis merozoites por Carletti, Tamara, Mesplet, Maria, Mira, Anabela, Weir, William, Shiels, Brian, Gonzalez Oliva, Abel, Schnittger, Leonhard, Florin-Christensen, Mónica, Barreto, Carmo

“…The results of this study suggest that ovipain-2 constitutes a potential target for immunotherapies and drug development against ovine babesiosis.…”
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Effect of dietary flavonoids on hepatic CYP2E1 and 3A4 activity : implication for food-drug interactions por Östlund, Johanna

“…This study provided gained insight in human cytochrome 450 regulation in presence of fla-vonoids and the results can contribute to research in drug development.…”

Indigenous livestock husbandry and ethno veterinary practices in Endamohoni District of Tigray Region, Ethiopia por Abraha, F.

“…And further biological studies should be conducted on the reported medicinal plant species of the study area so as to utilize them in drug development.…”
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In vitro inhibition of CYP1A and CYP3A by phenolic compounds from bilberry (Vaccinium myrtillus), in male and female porcine liver microsomes por Woll, Felicia

“…He-patic microsomes are useful in vitro model commonly used at early stages of drug develop-ment to identify potential food-drug or drug-drug interactions. …”
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Control de calidad fisicoquímico de bioplaguicidas microbianos por Grijalba Bernal, Erika Paola

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