Resultados de búsqueda - "Drug"

  1. Variations in packed red cell volume and trypanosome prevalence and relationships with reproductive traits in East African Zebu cows exposed to drug-resistant trypanosomes por Rowlands, G.J., Woudyalew Mulatu, Nagda, S.M., D'Ieteren, G.D.M.

    Publicado 1995
    “…Approximately 320 East African Zebu cows over 36 months of age were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cows were individually treated with diminazene aceturate, either when they were detected parasitaemic and their packed red cell volume (PCV) decreased below 26 percent or when they showed clinical signs of trypanosomiasis. …”
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  2. Economic analysis of animal disease control inputs at farm level: the case of trypanocide use in villages under risk of drug resistance in West Africa por Affognon, Hippolyte D., Randolph, Thomas F., Waibel, H.

    Publicado 2010
    “…This paper presents an economic analysis of the use of drugs (isometamidium and diminazene) in controlling African Animal Trypanosomosis (AAT), a serious disease of cattle and small ruminants in villages that exhibit resistance to isometamidium in Burkina Faso and Mali in West Africa. …”
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  3. Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products : potential pH-dependent inhibition explored through computer-aided drug design por Goyzueta-Mamani, Luis Daniel, Barazorda-Ccahuana, Haruna Luz, Candia-Puma, Mayron Antonio, Galdino, Alexsandro Sobreira, Machado-de-Avila, Ricardo Andrez, Giunchetti, Rodolfo Cordeiro, Medina-Franco, José L., Florin-Christensen, Mónica, Ferraz Coelho, Eduardo Antonio, Chavez Fumagalli, Miguel Angel

    Publicado 2024
    “…Using computer-aided drug design (CADD) approaches, the potential inhibitory effect of these NP candidates was evaluated by inhibiting the Mannosyl-oligosaccharide Glucosidase Protein (MOGS) from Leishmania infantum, an enzyme essential for the protein glycosylation process, at various pH to mimic the parasite’s changing environment. …”
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  4. Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry por Pascual, María José, Merwaiss, Fernando, Leal, Emilse Soledad, Quintana, Maria Eugenia, Capozzo, Alejandra Victoria, Cavasotto, Claudio Norberto, Bollini, Mariela, Alvarez, Diego Ezequiel

    Publicado 2019
    “…Using reverse genetics we constructed a recombinant BVDV expressing GFP that served as a sensitive reporter for the study of the mechanism of action of antiviral compounds. Time of drug addition assays showed that PTC12 inhibited an early step of infection. …”
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