Pros and cons of different therapeutic antibody formats for recombinant antivenom development
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molec...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://www.sciencedirect.com/science/article/pii/S0041010118301144?via%3Dihub https://hdl.handle.net/10669/76544 |
| Summary: | Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many
advances in immunology, synthetic biology, and antibody research, different approaches and antibody
formats are being investigated for the ability to neutralize animal toxins. These different molecular
formats each have their own therapeutic characteristics. In this review, we provide an overview of the
advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks
of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic
features, propensity to cause adverse reactions, formulation, and expression for research and development
(R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the
use of human antibody formats as well as camelid heavy-domain antibody fragments due to their
compatibility with the human immune system, beneficial therapeutic properties, and the ability to
manufacture these molecules cost-effectively. |
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