Proteoform-resolved quantitative venomics: looking through a crystal ball
In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the veno...
| Main Authors: | , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://jvat.biomedcentral.com/articles/10.1186/s40409-017-0116-9 https://hdl.handle.net/10669/74787 |
| Summary: | In this paper we discuss recent significant developments in the field of venom research, specifically the emergence
of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species
present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here
to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal
of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code
concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and
automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a
venom. This short essay reflects |
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