Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.

Bibliographic Details
Title: Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.
Authors: Guo WH; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Qi X; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Yu X; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Liu Y; Division of Cancer Medicine, Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Chung CI; Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, CA, 94158, USA., Bai F; Center for Theoretical Biological Physics, Rice University, Houston, TX, 77005, USA., Lin X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Lu D; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Wang L; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Chen J; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Su LH; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Nomie KJ; Division of Cancer Medicine, Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Li F; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Wang MC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, 77030, USA.; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA., Shu X; Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, CA, 94158, USA., Onuchic JN; Center for Theoretical Biological Physics, Rice University, Houston, TX, 77005, USA., Woyach JA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA., Wang ML; Division of Cancer Medicine, Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wang J; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA. wangj@bcm.edu.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA. wangj@bcm.edu.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA. wangj@bcm.edu.
Source: Nature communications [Nat Commun] 2020 Aug 26; Vol. 11 (1), pp. 4268. Date of Electronic Publication: 2020 Aug 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Complete
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Description
ISSN:2041-1723
DOI:10.1038/s41467-020-17997-6