Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes
|Title:||Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes|
|Source:||EMBO journal, 4 (4|
|Added Details:||Guyaux, Michel
Cornelissen, A W
|Document Type:||Electronic Resource|
|Abstract:||The mRNAs for variant surface glycoproteins (VSGs) and many other proteins in Trypanosoma brucei start with the same sequence of 35 nucleotides, encoded by a separate mini-exon. There are approximately 200 mini-exon genes per trypanosome and these are highly clustered on large chromosomes. We have found two trypanosome variants that express a VSG gene located on a small, 225-kb chromosome. Each gene yields a mRNA containing the 35-nucleotide sequence even though the 225-kb chromosome does not contain a complete mini-exon gene. These results provide a strong support for the hypothesis that transcription of protein-coding genes in trypanosomes is discontinuous.
Research Support, Non-U.S. Gov't
|Index Terms:||Sciences bio-médicales et agricoles, Animals, Base Sequence, Chromosomes -- physiology, Chromosomes -- ultrastructure, Cloning, Molecular, DNA -- analysis, Glycoproteins -- genetics, Molecular Weight, Nucleic Acid Hybridization, RNA, Messenger -- genetics, Rats, Transcription, Genetic, Trypanosoma brucei brucei -- genetics, Variant Surface Glycoproteins, Trypanosoma, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article|
|Availability:||Open access content. Open access content
2 full-text file(s): info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/restrictedAccess
|Note:||2 full-text file(s): application/pdf | application/pdf
|Other Numbers:||EQY oai:dipot.ulb.ac.be:2013/58393
|Contributing Source:||UNIVERSITE LIBRE DE BRUXELLES
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