Electronic Resource

Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes

Bibliographic Details
Title: Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes
Source: EMBO journal, 4 (4
Publisher Information: 1985-04
Added Details: Guyaux, Michel
Cornelissen, A W
Pays, Etienne
Steinert, Maurice
Borst, P
Document Type: Electronic Resource
Abstract: The mRNAs for variant surface glycoproteins (VSGs) and many other proteins in Trypanosoma brucei start with the same sequence of 35 nucleotides, encoded by a separate mini-exon. There are approximately 200 mini-exon genes per trypanosome and these are highly clustered on large chromosomes. We have found two trypanosome variants that express a VSG gene located on a small, 225-kb chromosome. Each gene yields a mRNA containing the 35-nucleotide sequence even though the 225-kb chromosome does not contain a complete mini-exon gene. These results provide a strong support for the hypothesis that transcription of protein-coding genes in trypanosomes is discontinuous.
Journal Article
Research Support, Non-U.S. Gov't
FLWIN
info:eu-repo/semantics/published
Index Terms: Sciences bio-médicales et agricoles, Animals, Base Sequence, Chromosomes -- physiology, Chromosomes -- ultrastructure, Cloning, Molecular, DNA -- analysis, Glycoproteins -- genetics, Molecular Weight, Nucleic Acid Hybridization, RNA, Messenger -- genetics, Rats, Transcription, Genetic, Trypanosoma brucei brucei -- genetics, Variant Surface Glycoproteins, Trypanosoma, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/58393/5/58393.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/58393/6/PMC554290.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/58393
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Availability: Open access content. Open access content
2 full-text file(s): info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/restrictedAccess
Note: 2 full-text file(s): application/pdf | application/pdf
English
Other Numbers: EQY oai:dipot.ulb.ac.be:2013/58393
uri/info:doi/10.1002/j.1460-2075.1985.tb03729.x
uri/info:pmid/3839457
uri/info:pmcid/PMC554290
764592798
Contributing Source: UNIVERSITE LIBRE DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Accession Number: edsoai.ocn764592798
Database: OAIster
Description
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