A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery

Bibliographic Details
Title: A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery
Authors: Ke Jiang, Weishu Ni, Xianying Cao, Ling Zhang, Shiwei Lin
Source: Materials Today Bio
Materials Today Bio, Vol 13, Iss, Pp 100180-(2022)
Publisher Information: Elsevier BV, 2022.
Publication Year: 2022
Subject Terms: Medicine (General), Surface engineering, QH301-705.5, Biomedical Engineering, Bioengineering, Cell Biology, metal-Organic framework, Crystal size control, Biomaterials, R5-920, Full Length Article, Biology (General), Molecular Biology, Controlled drug delivery, Biotechnology
Description: Controlling the crystal size and surface chemistry of MOF materials, and understanding their multifunctional effect are of great significance for the biomedical applications of MOF systems. Herein, we designed and synthesized a new anionic MOF, ZJU-64-NSN, which features 1D channels decorated with highly polarized thiadiazole groups, and its crystal size could be systematically tuned from 200 ​μm to 300 ​nm through a green and simple approach. As a result, the optimal nanosized ZJU-64-NSN is found to enable an ultrafast loading of cationic drug procainamide (PA) (21.2 ​wt% within 1 ​min). Moreover, the undesirable chemical stability of PA@ZJU-64-NSN is greatly improved by the surface coating of polyethylene glycol (PEG) biopolymer. The final drug delivery system PEG/PA@ZJU-64-NSN is found to effectively prevent PA from premature release under the harsh stomach environments due to the intense host-guest interaction, and mainly release PA to the targeted intestinal surroundings. Such controlled drug delivery is proved to be triggered by endogenic Na+ ions instead of H+ ions, well revealed by the study on the dynamics behavior of drug release and UV–Vis absorption spectrum. Good biocompatibility of ZJU-64-NSN and PEG-coated ZJU-64-NSN has been fully demonstrated by MTT assay as well as confocal microscopy imaging.
Graphical abstract Image 1
Highlights • A new anionic MOF enables an ultrafast drug loading. • The crystal size of such MOF could be well size-controlled. • The surface coating of PEG improves the chemical stability of drug carrier. • The drug delivery system reveals an endogenic Na ​+ ​-triggered procainamide release.
ISSN: 2590-0064
Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8896f83d67304a731214ebf1618849
Rights: OPEN
Accession Number: edsair.doi.dedup.....af8896f83d67304a731214ebf1618849
Database: OpenAIRE