Academic Journal

SEAKER cells coordinate cellular immunotherapy with localized chemotherapy.

Bibliographic Details
Title: SEAKER cells coordinate cellular immunotherapy with localized chemotherapy.
Authors: Lane IC; Massachusetts General Hospital Center for Cancer Research, Boston, MA, USA; Massachusetts General Hospital Department of Pathology, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Jan M; Massachusetts General Hospital Center for Cancer Research, Boston, MA, USA; Massachusetts General Hospital Department of Pathology, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. Electronic address: mjan@mgh.harvard.edu.
Source: Trends in pharmacological sciences [Trends Pharmacol Sci] 2022 Oct; Vol. 43 (10), pp. 804-805. Date of Electronic Publication: 2022 Apr 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Comment
Language: English
Journal Info: Publisher: Published By Elsevier In Association With The International Union Of Pharmacology Country of Publication: England NLM ID: 7906158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3735 (Electronic) Linking ISSN: 01656147 NLM ISO Abbreviation: Trends Pharmacol Sci Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Published By Elsevier In Association With The International Union Of Pharmacology
Original Publication: Amsterdam, Published by Elsevier in association with the International Union of Pharmacology.
MeSH Terms: Immunotherapy* , Neoplasms*/drug therapy, Antigens, Neoplasm ; Humans ; Immunotherapy, Adoptive ; Tumor Escape
Abstract: Tumor antigen escape and T cell dysfunction limit the effectiveness of chimeric antigen receptor (CAR) T cell therapies. To overcome these challenges, Gardner et al. engineered synthetic enzyme-armed killer (SEAKER) cells to coexpress a CAR and a prodrug-activating enzyme to orchestrate a dual immunologic and pharmacologic attack at the tumor site.
Competing Interests: Declaration of interests None are declared.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Comments: Comment on: Nat Chem Biol. 2022 Feb;18(2):216-225. (PMID: 34969970)
Grant Information: K08 CA255932 United States CA NCI NIH HHS
Contributed Indexing: Keywords: cell therapy; synthetic biology
Substance Nomenclature: 0 (Antigens, Neoplasm)
Entry Date(s): Date Created: 20220501 Date Completed: 20220913 Latest Revision: 20230115
Update Code: 20230115
DOI: 10.1016/j.tips.2022.04.001
PMID: 35491262
Database: MEDLINE
Description
ISSN:1873-3735
DOI:10.1016/j.tips.2022.04.001