Academic Journal
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy.
| Title: | SEAKER cells coordinate cellular immunotherapy with localized chemotherapy. |
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| Authors: | Lane IC; Massachusetts General Hospital Center for Cancer Research, Boston, MA, USA; Massachusetts General Hospital Department of Pathology, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Jan M; Massachusetts General Hospital Center for Cancer Research, Boston, MA, USA; Massachusetts General Hospital Department of Pathology, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. Electronic address: mjan@mgh.harvard.edu. |
| Source: | Trends in pharmacological sciences [Trends Pharmacol Sci] 2022 Oct; Vol. 43 (10), pp. 804-805. Date of Electronic Publication: 2022 Apr 28. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Comment |
| Language: | English |
| Journal Info: | Publisher: Published By Elsevier In Association With The International Union Of Pharmacology Country of Publication: England NLM ID: 7906158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3735 (Electronic) Linking ISSN: 01656147 NLM ISO Abbreviation: Trends Pharmacol Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Published By Elsevier In Association With The International Union Of Pharmacology Original Publication: Amsterdam, Published by Elsevier in association with the International Union of Pharmacology. |
| MeSH Terms: | Immunotherapy* , Neoplasms*/drug therapy, Antigens, Neoplasm ; Humans ; Immunotherapy, Adoptive ; Tumor Escape |
| Abstract: | Tumor antigen escape and T cell dysfunction limit the effectiveness of chimeric antigen receptor (CAR) T cell therapies. To overcome these challenges, Gardner et al. engineered synthetic enzyme-armed killer (SEAKER) cells to coexpress a CAR and a prodrug-activating enzyme to orchestrate a dual immunologic and pharmacologic attack at the tumor site. Competing Interests: Declaration of interests None are declared. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| Comments: | Comment on: Nat Chem Biol. 2022 Feb;18(2):216-225. (PMID: 34969970) |
| Grant Information: | K08 CA255932 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: cell therapy; synthetic biology |
| Substance Nomenclature: | 0 (Antigens, Neoplasm) |
| Entry Date(s): | Date Created: 20220501 Date Completed: 20220913 Latest Revision: 20230115 |
| Update Code: | 20230115 |
| DOI: | 10.1016/j.tips.2022.04.001 |
| PMID: | 35491262 |
| Database: | MEDLINE |
| ISSN: | 1873-3735 |
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| DOI: | 10.1016/j.tips.2022.04.001 |