Academic Journal

A Commotion in the Skin: Developing Melanoma Immunotherapies.

Bibliographic Details
Title: A Commotion in the Skin: Developing Melanoma Immunotherapies.
Authors: Brenner E; Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany., Röcken M; Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany. Electronic address:
Source: The Journal of investigative dermatology [J Invest Dermatol] 2022 Aug; Vol. 142 (8), pp. 2055-2060. Date of Electronic Publication: 2022 Mar 24.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Language: English
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE
Imprint Name(s): Publication: 2016- : New York : Elsevier
Original Publication: Baltimore, Williams & Wilkins.
MeSH Terms: Immunotherapy*/methods , Melanoma*/drug therapy, Antigens, Neoplasm ; Humans ; Immunotherapy, Adoptive ; T-Lymphocytes, Cytotoxic
Abstract: Melanomas are malignant tumors that can partly and very rarely completely regress in response to immune responses. Analyzing the mechanisms underlying this immune-mediated rejection, melanomas became leading in developing general cancer immunotherapy. This resulted in the discovery of tumor-specific neoantigens and mutations autoantigens, now called tumor-associated antigens, and their specific recognition by cytotoxic T lymphocytes. Melanomas were of key importance for the development of adoptive T-cell therapy and active tumor vaccines, namely dendritic cell vaccines. Melanoma therapy with antibodies against CTLA-4 provided the proof of concept that solid cancers can be susceptible to cancer immunotherapy, and melanoma therapy with antibodies against PD-1 resulted in the clinical breakthrough of cancer immunotherapy. Still, about half of patients die from metastatic melanoma. Combining anti‒PD-1 with anti‒CTLA-4 antibodies to increase antitumor immune responses or with targeted therapy improves the overall survival only partially. Recent data revealed a close link between defects in the IFN-γ‒dependent induction of cell cycle control genes and resistance to immunotherapy, which may allow for identifying those patients that respond to immunotherapy and to develop novel therapies, combining cancer immunotherapy with cell cycle inhibitors.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Substance Nomenclature: 0 (Antigens, Neoplasm)
Entry Date(s): Date Created: 20220327 Date Completed: 20220726 Latest Revision: 20220821
Update Code: 20221216
DOI: 10.1016/j.jid.2022.01.025
PMID: 35339277
Database: MEDLINE