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Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents.

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Title: Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents.
Authors: Abbasi-Malati Z; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.; Medical Biotechnology Research Center, Paramedicine Faculty, Guilan University of Medical Sciences, Rasht, Iran., Roushandeh AM; Medical Biotechnology Research Center, Paramedicine Faculty, Guilan University of Medical Sciences, Rasht, Iran., Kuwahara Y; Division of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Roudkenar MH; Cardiovascular Disease Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. roudkenar@gums.ac.ir.
Source: Stem cell reviews and reports [Stem Cell Rev Rep] 2018 Aug; Vol. 14 (4), pp. 484-499.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Language: English
Journal Info: Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101752767 Publication Model: Print Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE
Imprint Name(s): Publication: 2011- : [New York, NY] : Springer Science+Business Media
Original Publication: [Totowa, N.J.] : Humana Press, [2009]-
MeSH Terms: Cell Differentiation*, Cytokines/*metabolism , Intercellular Signaling Peptides and Proteins/*metabolism , Mesenchymal Stem Cell Transplantation/*methods , Mesenchymal Stem Cells/*cytology , Mesenchymal Stem Cells/*metabolism, Cell Communication ; Culture Media, Conditioned/metabolism ; Humans ; Regenerative Medicine/methods
Abstract: Over 10 years, mesenchymal stem cells (MSCs) have been considered as valuable and suitable cells for cell-based therapy applications, particularly in clinical trials. In any case, they are as yet not utilized routinely in clinics. At first, it was believed that MSCs play their roles, especially in regenerative medicine due to their differentiation and cell replacement properties. Interestingly, it is well-known that MSCs mainly exert their therapeutic effects through their vast bioactive factors. These findings turned scientists' consideration toward cell-free therapy concepts. From this point of view, MSCs can be considered as an arsenal of natural bioreactors in variety of therapeutic agents. MSCs inherently express various important therapeutic agents such as growth factors and cytokines that can be manufactured, handled and stored as a prepared-to-go biologic product. In this review, we provide a vision, highlight as well as discuss in order to introduce competitive natural robust bioreactor MSCs on the horizon.
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Grant Information: IR.GUMS.REC.1396. 343 International Guilan University of Medical Sciences
Contributed Indexing: Keywords: Cell-free therapy; Condition medium; MSC; Secretome; Therapeutic agents
Substance Nomenclature: 0 (Culture Media, Conditioned)
0 (Cytokines)
0 (Intercellular Signaling Peptides and Proteins)
Entry Date(s): Date Created: 20180425 Date Completed: 20181217 Latest Revision: 20220318
Update Code: 20221213
DOI: 10.1007/s12015-018-9817-x
PMID: 29687338
Database: MEDLINE
Description
ISSN:2629-3277
DOI:10.1007/s12015-018-9817-x