Search Results - "Transforming Growth Factor beta metabolism"

1

Induction and transmission of oncogene-induced senescence

Authors: Tamir Chandra, Kristina Kirschner, Nattaphong Rattanavirotkul

Source: Rattanavirotkul, N, Kirschner, K & Chandra, T 2021, ' Induction and transmission of oncogene-induced senescence ', Cellular and Molecular Life Sciences, vol. 78, no. 3, pp. 843-852 . https://doi.org/10.1007/s00018-020-03638-0
Cellular and Molecular Life Sciences

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https://www.pure.ed.ac.uk/ws/files/216626835/Induction_and_transmission_of_oncogene_induced_senescence.pdf

2

Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model

Authors: Silva, C, Sampaio-Pinto, V, Andrade, S, Rodrigues, I, Costa, R, Guerreiro, SG, Carvalho, E, Pinto-do-Ó, P, Nascimento, DS, Soares, R

Contributors: Instituto de Investigação e Inovação em Saúde

Source: Cellular Physiology and Biochemistry, Vol 52, Iss 3, Pp 503-516 (2019)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Subject Terms: lcsh:Physiology, lcsh:QP1-981, lcsh:Biochemistry, lcsh:QD415-436, Article, Carbohydrate and lipid metabolism, Cell sorting, Endothelium metabolism, Genomics, Micro and macrovascular complications, Physiology, Endothelial stem cell, CTGF, Pathology, medicine.medical_specialty, medicine, Kidney, medicine.anatomical_structure, Growth factor, medicine.medical_treatment, Sirius Red, chemistry.chemical_compound, chemistry, Fibrosis, medicine.disease, Diabetes mellitus, business.industry, business, Angiogenesis, Macrovascular complications, Micro, Animals, Connective Tissue Growth Factor / analysis, Connective Tissue Growth Factor / metabolism, Diabetes Mellitus, Experimental / chemically induced, Diabetes Mellitus, Experimental / metabolism, Diabetes Mellitus, Experimental / pathology, Disease Models, Animal, Endothelial Cells / cytology, Endothelial Cells / metabolism, Heart Ventricles / metabolism, Kidney / cytology, Kidney / metabolism, Male, Mice, Mice, Inbred C57BL, Microvessels / pathology, Microvessels / physiology, Myocardium / cytology, Myocardium / metabolism, Neovascularization, Pathologic, Platelet Endothelial Cell Adhesion Molecule-1 / metabolism, Receptors, Notch / metabolism, Tissue Inhibitor of Metalloproteinase-2 / genetics, Tissue Inhibitor of Metalloproteinase-2 / metabolism, Transcriptome, Transforming Growth Factor beta / genetics, Transforming Growth Factor beta / metabolism, Vascular Endothelial Growth Factor Receptor-2 / genetics, Vascular Endothelial Growth Factor Receptor-2 / metabolism

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https://www.cellphysiolbiochem.com/Articles/000036/

3

KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

Authors: Ruud A. Bank, Pernette J. Verschure, Marianne G. Rots, Uilke Brouwer, Christian Huisman, Désirée Goubert, Consuelo Del Pilar García Tobilla, Antal Kiss, Rutger A. F. Gjaltema, Pytrick Jellema, Dan-Dan Wu, Mihály Koncz

Contributors: Synthetic Systems Biology (SILS, FNWI), ACTA, Groningen Kidney Center (GKC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Source: International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences, 21(10):3634. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 3634, p 3634 (2020)
International Journal of Molecular Sciences, 21(10):3634. MDPI AG

Subject Terms: epigenetic editing, KRAB, gene repression, PLOD2, fibrosis, cancer, Adult, Cells, Cultured, DNA-Cytosine Methylases/genetics, Epigenesis, Genetic, Gene Silencing, HEK293 Cells, Heterochromatin/metabolism, Humans, Kruppel-Like Transcription Factors/genetics, MCF-7 Cells, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics, Promoter Regions, Genetic, Transcriptional Activation, Transforming Growth Factor beta/metabolism, lcsh:Biology (General), lcsh:QH301-705.5, lcsh:Chemistry, lcsh:QD1-999, Article, Cells, Cultured, Epigenesis, Genetic, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics, Promoter Regions, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis, DNA methylation, Gene silencing, Reprogramming, Gene expression, Cell biology, Biology, Epigenetics, Heterochromatin, Histone, biology.protein, DNA methyltransferase

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4

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Contributors: Cardiovascular and Metabolic Disorders [Singapor] (cvmd), Duke-NUS Medical School [Singapore], University of Bari Aldo Moro (UNIBA), Ospedale San Giovanni di Dio, Firenze, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine [London, UK], Imperial College London, Agency for science, technology and research [Singapore] (A*STAR), Institute of Molecular and Cell Biology, National University of Singapore (NUS)-Agency for science, technology and research [Singapore] (A*STAR), MRC London Institute of Medical Sciences (LMC), National Heart Centre Singapore (NHCS), Royal Brompton and Harefield NHS Foundation Trust, Cardiovascular Research Centre [London], Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain] (CNIC), Instituto de Salud Carlos III [Madrid] (ISC), University of Bristol [Bristol], Institute of Physiology [Prague], Czech Academy of Sciences [Prague] (CAS), University of Cambridge [UK] (CAM), The Alan Turing Institute, MRC Biostatistics Unit [Cambridge, UK], Max Delbrück Center for Molecular Medicine [Berlin] (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], The research was primarily supported by National Medical Research Council (NMRC) Singapore grant NMRC/CBRG/0106/2016 (to E.P.) and the British Heart Foundation (BHF) Ph.D. Studentship grant FS/11/25/28740 (to E.P). We acknowledge additional funding support from European Union FP7 CardioNeT-ITN-289600 (to E.L.-P., S.A.C., and P.J.R.B.), Heart Research UK (to P.J.R.B.), NIHR CV BRU of Royal Brompton and Harefield, NHS Foundation Trust (to S.A.C. and P.J.R.B.), BHF (to S.A.C.), Leducq Foundation (to S.A.C.), MRC UK (to S.A.C.), BHF Program Grant no. RG/15/5/31446 (to C.E. and E.P.). M.P. was supported by Praemium Academiae award of the Czech Academy of Sciences and grant 14-36804G from the Czech Science Foundation., We wish to thank Dr. Jacques Behmoaras for contributing critical and constructive comments to the manuscript., European Project: 289600,EC:FP7:PEOPLE,FP7-PEOPLE-2011-ITN,CARDIONET(2012), Leducq Foundation for Cardiovascular Research, Commission of the European Communities, Heart Research UK, Fondation Leducq, British Heart Foundation, Medical Research Council (MRC), National Medical Research Council of Singapore, European Commission, National Institutes of Health (United States), Czech Science Foundation, Leducq Foundation, NHS Foundation Trusth

Source: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Chen, H, Moreno-Moral, A, Pesce, F, Devapragash, N, Mancini, M, Heng, E L, Rotival, M, Srivastava, P K, Harmston, N, Shkura, K, Rackham, O J L, Yu, W P, Sun, X M, Tee, N G Z, Tan, E L S, Barton, P J R, Felkin, L E, Lara-Pezzi, E, Angelini, G, Beltrami, C, Pravenec, M, Schafer, S, Bottolo, L, Hubner, N, Emanueli, C, Cook, S A & Petretto, E 2019, ' WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signalling ', Nature Communications, vol. 10, 3616 . https://doi.org/10.1038/s41467-019-11551-9

Subject Terms: Cardiomyopathies, Ubiquitin ligases, MESH: Adolescent, MESH: Adult, MESH: Fibrosis / genetics, MESH: Fibrosis / metabolism, MESH: Mice, Transgenic, MESH: Gene Regulatory Networks, MESH: Genetic Predisposition to Disease* / genetics, MESH: Heart Diseases / genetics, MESH: Heart Diseases / metabolism, MESH: Humans, MESH: Male, MESH: Mice, MESH: Ubiquitin-Protein Ligases / metabolism, MESH: Middle Aged, MESH: Aged, MESH: Protein Isoforms, MESH: Smad2 Protein / genetics, MESH: Smad2 Protein / metabolism, MESH: Transforming Growth Factor beta / metabolism, MESH: Ubiquitin-Protein Ligases / genetics, MESH: Young Adult, MESH: Gene Expression Regulation, MESH: Animals, MESH: Cardiomyopathies / genetics, MESH: Cardiomyopathies / metabolism, MESH: Extracellular Matrix Proteins / metabolism, MESH: Female, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Article, 631/45/474/2073, 692/4019/592/75/74, 38/39, 13/51, 13/89, 42/44, 14/32, 14/35, 45/43, 64/60, 82/80, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Pressure overload, Myocardial fibrosis, Heart failure, medicine.disease, medicine, Fibrosis, Ubiquitin ligase, biology.protein, biology, Cell biology, WWP2, Regulation of gene expression, Cardiac fibrosis, Cardiovascular and Metabolic Diseases, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, E3 UBIQUITIN LIGASE, TGF-BETA, GENE-EXPRESSION, HEART-FAILURE, BLOOD-PRESSURE, FIBROBLAST, REVEALS, RAT, IDENTIFICATION, DETERMINANT, Adolescent, Adult, Aged, Animals, Extracellular Matrix Proteins, Female, Gene Expression Regulation, Gene Regulatory Networks, Genetic Predisposition to Disease, Heart Diseases, Humans, Male, Mice, Mice, Transgenic, Middle Aged, Protein Isoforms, Smad2 Protein, Transforming Growth Factor beta, Ubiquitin-Protein Ligases, Young Adult, Science, Centre for Surgical Research, lcsh:Science, lcsh:Q

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02868982

5

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

Source: eLife, Vol 8 (2019)
eLife
eLife, vol. 8

Subject Terms: General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, General Neuroscience, Endocrinology, medicine.medical_specialty, medicine, Gonadotropin-releasing hormone, Hormone, Internal medicine, GnRH Neuron, Anosmia, medicine.symptom, Kallmann's syndrome, Biology, Hypogonadotropic hypogonadism, medicine.disease, Kallmann syndrome, Congenital Hypogonadotropic Hypogonadism, GnRH, reproduction, AMH, cell migration, Medicine, Science, Biology (General), QH301-705.5, Research Article, Developmental Biology, Genetics and Genomics, Human, Mouse, Adolescent, Adult, Amino acid sequence, Animals, Anti-mullerian hormone, Axons, Bone morphogenetic protein receptors, type I, Cell movement, Chlorocebus aethiops, COS cells, Female, Fertility, Fetus, Heterozygote, Humans, Hypogonadism, Loss of function mutation, Luteinizing hormone, Male, Mice, Inbred C57BL, Neurons, Olfactory bulb, Pedigree, Receptors, transforming growth factor beta, Signal transduction, Young adult, Amino Acid Sequence, Anti-Mullerian Hormone/genetics, Anti-Mullerian Hormone/metabolism, Axons/metabolism, Bone Morphogenetic Protein Receptors, Type I/metabolism, COS Cells, Cell Movement, Fetus/metabolism, Gonadotropin-Releasing Hormone/metabolism, Hypogonadism/metabolism, Loss of Function Mutation, Luteinizing Hormone/metabolism, Neurons/metabolism, Olfactory Bulb/metabolism, Receptors, Transforming Growth Factor beta/deficiency, Receptors, Transforming Growth Factor beta/genetics, Receptors, Transforming Growth Factor beta/metabolism, Signal Transduction, Young Adult, developmental biology, genetics, genomics, human, mouse, endocrine system, hormones, hormone substitutes, and hormone antagonists

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6

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Authors: Bernink, Jochem H., Ohne, Yoichiro, Teunissen, Marcel B. M., Wang, Jingya, Wu, Jincheng, Krabbendam, Lisette, Guntermann, Christine, Volckmann, Richard, Koster, Jan, van Tol, Sophie, Ramirez, Ivan, Shrestha, Yashaswi, de Rie, Menno A., Spits, Hergen, Romero Ros, Xavier, Humbles, Alison A.

Contributors: Dermatology, Graduate School, AGEM - Digestive immunity, AII - Inflammatory diseases, Oncogenomics, Experimental Immunology

Source: Nature immunology, 20(8), 992-1003. Nature Publishing Group

Subject Terms: Immunology, Immunology and Allergy, Interleukin 17, Cytokine, medicine.medical_treatment, medicine, Receptor, Innate lymphoid cell, Cell biology, RAR-related orphan receptor gamma, C-C chemokine receptor type 6, Transforming growth factor, Biology, Downregulation and upregulation, Cells, Cultured, Humans, Interleukin-17/immunology, Interleukin-1beta/immunology, Interleukin-23 Subunit p19/immunology, Interleukin-4/immunology, Lymphocytes/cytology, Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism, Proto-Oncogene Proteins c-kit/metabolism, Psoriasis/immunology, Receptors, CCR10/metabolism, Skin/immunology, Transforming Growth Factor beta/metabolism, Cells, Cultured, Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism, Receptors, CCR10/metabolism

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7

Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release While Enhancing Galectin-9, TGFβ, and Th1 Polarization

Authors: Overbeek, Saskia A., Kostadinova, Atanaska I., Boks, Martine A., Hayen, Simone M., de Jager, Wilco, van’t land, Belinda, Knippels, Leon M., Garssen, Johan, Willemsen, Linette E. M.

Contributors: Molecular cell biology and Immunology

Source: Mediators of Inflammation
Mediators of Inflammation, 2019
Mediators of Inflammation, Vol 2019 (2019)
Mediators of Inflammation, 2019:8456829. Hindawi Publishing Corporation

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http://europepmc.org/articles/PMC6683774

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8

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Authors: Kolliopoulos, Constantinos, Raja, Erna, Razmara, Masoud, Heldin, Paraskevi, Heldin, Carl-Henrik, Moustakas, Aristidis, van der Heide, Lars P.

Contributors: Molecular Neuroscience (SILS, FNWI)

Source: Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry, 294(11), 4119-4136. American Society for Biochemistry and Molecular Biology Inc.

Subject Terms: Signal Transduction, AMP-activated kinase (AMPK), cell cycle, epithelial-mesenchymal transition (EMT), myofibroblast, SMAD transcription factor, transforming growth factor beta (TGF-beta), cell signaling, NUAK family kinase, signal transduction, transforming growth factor beta (TGF-B), Cell and Molecular Biology, Cell- och molekylärbiologi, Cell Biology, Molecular Biology, Biochemistry, SMAD, Biology, Signal transduction, Kinase, Transforming growth factor, Protein kinase A, NUAK1, Cell biology, Tissue homeostasis, Cell signaling, Cells, Cultured, Gene Expression Profiling, Humans, Protein Kinases/genetics, Protein-Serine-Threonine Kinases/genetics, Real-Time Polymerase Chain Reaction, Repressor Proteins/genetics, Signal Transduction/genetics, Transforming Growth Factor beta/metabolism, Cells, Cultured

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9

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Authors: Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W.K., Luna, A., Konnor C., L., Dimitriadoy, S., Liu, D.L., Kantheti, H.S., Saghafinia, S., Chakravarty, D., Daian, F., Gao, Q., Bailey, M.H., Liang, W., Foltz, S.M., Shmulevich, I., Ding, L., Heins, Z., Ochoa, A., Gross, B., Gao, J., Zhang, H., Kundra, R., Kandoth, C., Bahceci, I., Dervishi, L., Dogrusoz, U., Zhou, W., Shen, H., Laird, P.W., Way, G.P., Greene, C.S., Liang, H., Xiao, Y., Wang, C., Iavarone, A., Berger, A.H., Bivona, T.G., Lazar, A.J., Hammer, G.D., Giordano, T., Kwong, L.N., McArthur, G., Huang, C., Tward, A.D., Frederick, M.J., McCormick, F., Meyerson, M., Van Allen, E.M., Cherniack, A.D., Ciriello, G., Sander, C., Schultz, N., Caesar-Johnson, S.J., Demchok, J.A., Felau, I., Kasapi, M., Ferguson, M.L., Hutter, C.M., Sofia, H.J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J.C., Zhang, J.(., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Ye, W., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D.I., Kim, J., Lawrence, M.S., Lin, P., Meier, S., Noble, M.S., Saksena, G., Voet, D., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Thorsson, V., Zhang, W., Akbani, R., Broom, B.M., Hegde, A.M., Zhenlin, J., Kanchi, R.S., Korkut, A., Jun, L., Ling, S., Liu, W., Yiling, L., Mills, G.B., Kwok-Shing, N., Rao, A., Ryan, M., Wang, J., Weinstein, J.N., Zhang, J., Abeshouse, A., de Bruijn, I., Gross, B.E., Heins, Z.J., Konnor, L., Ladanyi, M., Nissan, M.G., Phillips, S.M., Reznik, E., Sheridan, R., Sumer, S.O., Sun, Y., Taylor, B.S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J.M., Wong, C.K., Yau, C., Hayes, D.N., Parker, J.S., Wilkerson, M.D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S.J.M., Kasaian, K., Lee, D., Yussanne, M., Marra, M.A., Mayo, M., Moore, R.A., Mungall, A.J., Mungall, K., Robertson, A.G., Sadeghi, S., Schein, J.E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A.C., Beroukhim, R., Cibulskis, C., Gabriel, S.B., Gao, G.F., Gavin, H., Schumacher, S.E., Shih, J., Kucherlapati, M.H., Kucherlapati, R.S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M.S., Lai, P.H., Maglinte, D.T., Van Den Berg, D.J., Weisenberger, D.J., Auman, J.T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K.A., Hoyle, A.P., Jefferys, S.R., Jones, C.D., Meng, S., Mieczkowski, P.A., Mose, L.E., Perou, A.H., Perou, C.M., Roach, J., Shi, Y., Simons, J.V., Skelly, T., Soloway, M.G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Bellair, M., Chang, K., Covington, K., Creighton, C.J., Dinh, H., Doddapaneni, H., Donehower, L.A., Drummond, J., Gibbs, R.A., Glenn, R., Hale, W., Han, Y., Jianhong, H., Korchina, V., Lee, S., Lewis, L., Wei, L., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D.A., Zhao, F., Hess, J., Appelbaum, E.L., Bailey, M., Cordes, M.G., Fronick, C.C., Fulton, L.A., Fulton, R.S., Mardis, E.R., McLellan, M.D., Miller, C.A., Schmidt, H.K., Wilson, R.K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J.M., Gerken, M., Leraas, K.M., Lichtenberg, T.M., Ramirez, N.C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A.L., de Carvalho, A.C., Fregnani, J.H., Longatto-Filho, A., Reis, R.M., Scapulatempo-Neto, C., Silveira, H.C.S., Vidal, D.O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M.L., Castro, P.D., Ittmann, M., Huntsman, D., Kohl, B., Xuan, L., Thorp, R., Andry, C., Duffy, E.R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., McPherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C.P., Malykh, A., Barnholtz-Sloan, J.S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q.T., Shimmel, K., Wolinsky, Y., Sloan, A.E., De Rose, A., Giuliante, F., Goodman, M., Karlan, B.Y., Hagedorn, C.H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L.A., Deyarmin, B., Hai, H., Kvecher, L., Larson, C., Mural, R.J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Tê, tu, B., Bergeron, A., McGraw, M., Staugaitis, S.M., Chabot, J., Hibshoosh, H., Sepulveda, A., Tao, S., Wang, T., Potapova, O., Voronina, O., Desjardins, L., Mariani, O., Roman-Roman, S., Sastre, X., Stern, M., Cheng, F., Signoretti, S., Berchuck, A., Bigner, D., Lipp, E., Marks, J., McCall, S., McLendon, R., Secord, A., Sharp, A., Behera, M., Brat, D.J., Chen, A., Delman, K., Force, S., Khuri, F., Magliocca, K., Maithel, S., Olson, J.J., Owonikoko, T., Pickens, A., Ramalingam, S., Shin, D.M., Sica, G., Van Meir, E.G., Eijckenboom, W., Gillis, A., Korpershoek, E., Looijenga, L., Oosterhuis, W., Stoop, H., van Kessel, K.E., Zwarthoff, E.C., Calatozzolo, C., Cuppini, L., Cuzzubbo, S., DiMeco, F., Finocchiaro, G., Mattei, L., Perin, A., Pollo, B., Chen, C., Houck, J., Lohavanichbutr, P., Hartmann, A., Stoehr, C., Stoehr, R., Taubert, H., Wach, S., Wullich, B., Kycler, W., Murawa, D., Wiznerowicz, M., Chung, K., Edenfield, W.J., Martin, J., Baudin, E., Bubley, G., Bueno, R., De Rienzo, A., Richards, W.G., Kalkanis, S., Mikkelsen, T., Noushmehr, H., Scarpace, L., Girard, N., Aymerich, M., Campo, E., Giné, Guillermo, A.L., Van Bang, N., Hanh, P.T., Phu, B.D., Tang, Y., Colman, H., Evason, K., Dottino, P.R., Martignetti, J.A., Gabra, H., Juhl, H., Akeredolu, T., Stepa, S., Hoon, D., Ahn, K., Kang, K.J., Beuschlein, F., Breggia, A., Birrer, M., Bell, D., Borad, M., Bryce, A.H., Castle, E., Chandan, V., Cheville, J., Copland, J.A., Farnell, M., Flotte, T., Giama, N., Thai, H., Kendrick, M., Kocher, J., Kopp, K., Moser, C., Nagorney, D., O’, Brien, D., Neill, B.P., Patel, T., Petersen, G., Que, F., Rivera, M., Roberts, L., Smallridge, R., Smyrk, T., Stanton, M., Thompson, R.H., Torbenson, M., Yang, J.D., Zhang, L., Brimo, F., Ajani, J.A., Gonzalez, A.M.A., Behrens, C., Bondaruk, J., Broaddus, R., Czerniak, B., Esmaeli, B., Fujimoto, J., Gershenwald, J., Guo, C., Logothetis, C., Meric-Bernstam, F., Moran, C., Ramondetta, L., Rice, D., Sood, A., Tamboli, P., Thompson, T., Troncoso, P., Tsao, A., Wistuba, I., Carter, C., Haydu, L., Hersey, P., Jakrot, V., Kakavand, H., Kefford, R., Lee, K., Long, G., Mann, G., Quinn, M., Saw, R., Scolyer, R., Shannon, K., Spillane, A., Stretch, J., Synott, M., Thompson, J., Wilmott, J., Al-Ahmadie, H., Chan, T.A., Ghossein, R., Gopalan, A., Levine, D.A., Reuter, V., Singer, S., Singh, B., Tien, N.V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J., Hung, N.P., Kebebew, E., Linehan, W.M., Metwalli, A.R., Pacak, K., Pinto, P.A., Schiffman, M., Schmidt, L.S., Vocke, C.D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D.M., Rintoul, R.C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de Krijger, R., Gimenez-Roqueplo, A., Piché, Chevalier, S., McKercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N.A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J.A., Liptay, M.J., Pool, M., Seder, C.W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M.C., Cardinale, V., Carpino, G., Gaudio, E., Chesla, D., Cottingham, S., Dubina, M., Moiseenko, F., Dhanasekaran, R., Becker, K., Janssen, K., Slotta-Huspenina, J., Abdel-Rahman, M.H., Aziz, D., Bell, S., Cebulla, C.M., Davis, A., Duell, R., Elder, J.B., Hilty, J., Kumar, B., Lang, J., Lehman, N.L., Mandt, R., Nguyen, P., Pilarski, R., Rai, K., Schoenfield, L., Senecal, K., Wakely, P., Hansen, P., Lechan, R., Powers, J., Tischler, A., Grizzle, W.E., Sexton, K.C., Kastl, A., Henderson, J., Porten, S., Waldmann, J., Fassnacht, M., Asa, S.L., Schadendorf, D., Couce, M., Graefen, M., Huland, H., Sauter, G., Schlomm, T., Simon, R., Tennstedt, P., Olabode, O., Nelson, M., Bathe, O., Carroll, P.R., Chan, J.M., Disaia, P., Glenn, P., Kelley, R.K., Landen, C.N., Phillips, J., Prados, M., Simko, J., Smith-McCune, K., VandenBerg, S., Roggin, K., Fehrenbach, A., Kendler, A., Sifri, S., Steele, R., Jimeno, A., Carey, F., Forgie, I., Mannelli, M., Carney, M., Hernandez, B., Campos, B., Herold-Mende, C., Jungk, C., Unterberg, A., von Deimling, A., Bossler, A., Galbraith, J., Jacobus, L., Knudson, M., Knutson, T., Deqin, M., Milhem, M., Sigmund, R., Godwin, A.K., Madan, R., Rosenthal, H.G., Adebamowo, C., Adebamowo, S.N., Boussioutas, A., Beer, D., Mes-Masson, A., Saad, F., Bocklage, T., Landrum, L., Mannel, R., Moore, K., Moxley, K., Postier, R., Walker, J., Zuna, R., Feldman, M., Valdivieso, F., Dhir, R., Luketich, J., Pinero, E.M.M., Quintero-Aguilo, M., Carlotti, C.G., Dos Santos, J.S., Kemp, R., Sankarankuty, A., Tirapelli, D., Catto, J., Agnew, K., Swisher, E., Creaney, J., Robinson, B., Shelley, C.S., Godwin, E.M., Kendall, S., Shipman, C., Bradford, C., Carey, T., Haddad, A., Moyer, J., Peterson, L., Prince, M., Rozek, L., Wolf, G., Bowman, R., Fong, K.M., Yang, I., Korst, R., Rathmell, W.K., Fantacone-Campbell, J.L., Hooke, J.A., Kovatich, A.J., Shriver, C.D., DiPersio, J., Drake, B., Govindan, R., Heath, S., Ley, T., Van Tine, B., Westervelt, P., Rubin, M.A., Lee, J.I., Aredes, N.D., Mariamidze, A.

Contributors: SAIC-F-Frederick, Inc, Leidos Biomedical Research, Inc., Doğrusöz, Uğur, Cancer Genome Atlas Research Network, Caesar-Johnson, S.J., Demchok, J.A., Felau, I., Kasapi, M., Ferguson, M.L., Hutter, C.M., Sofia, H.J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J.C., Zhang, J.J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D.I., Kim, J., Lawrence, M.S., Lin, P., Meier, S., Noble, M.S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Shmulevich, I., Thorsson, V., Zhang, W., Akbani, R., Broom, B.M., Hegde, A.M., Ju, Z., Kanchi, R.S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G.B., Ng, K.S., Rao, A., Ryan, M., Wang, J., Weinstein, J.N., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W.K., de Bruijn, I., Gao, J., Gross, B.E., Heins, Z.J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M.G., Ochoa, A., Phillips, S.M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S.O., Sun, Y., Taylor, B.S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J.M., Wong, C.K., Yau, C., Hayes, D.N., Parker, J.S., Wilkerson, M.D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, SJM, Kasaian, K., Lee, D., Ma, Y., Marra, M.A., Mayo, M., Moore, R.A., Mungall, A.J., Mungall, K., Robertson, A.G., Sadeghi, S., Schein, J.E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A.C., Beroukhim, R., Cherniack, A.D., Cibulskis, C., Gabriel, S.B., Gao, G.F., Ha, G., Meyerson, M., Schumacher, S.E., Shih, J., Kucherlapati, M.H., Kucherlapati, R.S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M.S., Lai, P.H., Maglinte, D.T., Van Den Berg, D.J., Weisenberger, D.J., Auman, J.T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K.A., Hoyle, A.P., Jefferys, S.R., Jones, C.D., Meng, S., Mieczkowski, P.A., Mose, L.E., Perou, A.H., Perou, C.M., Roach, J., Shi, Y., Simons, J.V., Skelly, T., Soloway, M.G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Laird, P.W., Shen, H., Zhou, W., Bellair, M., Chang, K., Covington, K., Creighton, C.J., Dinh, H., Doddapaneni, H., Donehower, L.A., Drummond, J., Gibbs, R.A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D.A., Xi, L., Zhao, F., Hess, J., Appelbaum, E.L., Bailey, M., Cordes, M.G., Ding, L., Fronick, C.C., Fulton, L.A., Fulton, R.S., Kandoth, C., Mardis, E.R., McLellan, M.D., Miller, C.A., Schmidt, H.K., Wilson, R.K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J.M., Gerken, M., Leraas, K.M., Lichtenberg, T.M., Ramirez, N.C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A.L., de Carvalho, A.C., Fregnani, J.H., Longatto-Filho, A., Reis, R.M., Scapulatempo-Neto, C., Silveira, HCS, Vidal, D.O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M.L., Castro, P.D., Ittmann, M., Huntsman, D., Kohl, B., Le, X., Thorp, R., Andry, C., Duffy, E.R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., McPherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C.P., Malykh, A., Barnholtz-Sloan, J.S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q.T., Shimmel, K., Wolinsky, Y., Sloan, A.E., De Rose, A., Giuliante, F., Goodman, M., Karlan, B.Y., Hagedorn, C.H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L.A., Deyarmin, B., Hu, H., Kvecher, L., Larson, C., Mural, R.J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Têtu, B., Bergeron, A., McGraw, M., Staugaitis, S.M., Chabot, J., Hibshoosh, H., Sepulveda, A., Su, T., Wang, T., Potapova, O., Voronina, O., Desjardins, L., Mariani, O., Roman-Roman, S., Sastre, X., Stern, M.H., Cheng, F., Signoretti, S., Berchuck, A., Bigner, D., Lipp, E., Marks, J., McCall, S., McLendon, R., Secord, A., Sharp, A., Behera, M., Brat, D.J., Chen, A., Delman, K., Force, S., Khuri, F., Magliocca, K., Maithel, S., Olson, J.J., Owonikoko, T., Pickens, A., Ramalingam, S., Shin, D.M., Sica, G., Van Meir, E.G., Eijckenboom, W., Gillis, A., Korpershoek, E., Looijenga, L., Oosterhuis, W., Stoop, H., van Kessel, K.E., Zwarthoff, E.C., Calatozzolo, C., Cuppini, L., Cuzzubbo, S., DiMeco, F., Finocchiaro, G., Mattei, L., Perin, A., Pollo, B., Chen, C., Houck, J., Lohavanichbutr, P., Hartmann, A., Stoehr, C., Stoehr, R., Taubert, H., Wach, S., Wullich, B., Kycler, W., Murawa, D., Wiznerowicz, M., Chung, K., Edenfield, W.J., Martin, J., Baudin, E., Bubley, G., Bueno, R., De Rienzo, A., Richards, W.G., Kalkanis, S., Mikkelsen, T., Noushmehr, H., Scarpace, L., Girard, N., Aymerich, M., Campo, E., Giné, E., Guillermo, A.L., Van Bang, N., Hanh, P.T., Phu, B.D., Tang, Y., Colman, H., Evason, K., Dottino, P.R., Martignetti, J.A., Gabra, H., Juhl, H., Akeredolu, T., Stepa, S., Hoon, D., Ahn, K., Kang, K.J., Beuschlein, F., Breggia, A., Birrer, M., Bell, D., Borad, M., Bryce, A.H., Castle, E., Chandan, V., Cheville, J., Copland, J.A., Farnell, M., Flotte, T., Giama, N., Ho, T., Kendrick, M., Kocher, J.P., Kopp, K., Moser, C., Nagorney, D., O'Brien, D., O'Neill, B.P., Patel, T., Petersen, G., Que, F., Rivera, M., Roberts, L., Smallridge, R., Smyrk, T., Stanton, M., Thompson, R.H., Torbenson, M., Yang, J.D., Zhang, L., Brimo, F., Ajani, J.A., Gonzalez, AMA, Behrens, C., Bondaruk, J., Broaddus, R., Czerniak, B., Esmaeli, B., Fujimoto, J., Gershenwald, J., Guo, C., Lazar, A.J., Logothetis, C., Meric-Bernstam, F., Moran, C., Ramondetta, L., Rice, D., Sood, A., Tamboli, P., Thompson, T., Troncoso, P., Tsao, A., Wistuba, I., Carter, C., Haydu, L., Hersey, P., Jakrot, V., Kakavand, H., Kefford, R., Lee, K., Long, G., Mann, G., Quinn, M., Saw, R., Scolyer, R., Shannon, K., Spillane, A., Stretch, J., Synott, M., Thompson, J., Wilmott, J., Al-Ahmadie, H., Chan, T.A., Ghossein, R., Gopalan, A., Levine, D.A., Reuter, V., Singer, S., Singh, B., Tien, N.V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J.W., Hung, N.P., Kebebew, E., Linehan, W.M., Metwalli, A.R., Pacak, K., Pinto, P.A., Schiffman, M., Schmidt, L.S., Vocke, C.D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D.M., Rintoul, R.C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de Krijger, R., Gimenez-Roqueplo, A.P., Piché, A., Chevalier, S., McKercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N.A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J.A., Liptay, M.J., Pool, M., Seder, C.W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M.C., Cardinale, V., Carpino, G., Gaudio, E., Chesla, D., Cottingham, S., Dubina, M., Moiseenko, F., Dhanasekaran, R., Becker, K.F., Janssen, K.P., Slotta-Huspenina, J., Abdel-Rahman, M.H., Aziz, D., Bell, S., Cebulla, C.M., Davis, A., Duell, R., Elder, J.B., Hilty, J., Kumar, B., Lang, J., Lehman, N.L., Mandt, R., Nguyen, P., Pilarski, R., Rai, K., Schoenfield, L., Senecal, K., Wakely, P., Hansen, P., Lechan, R., Powers, J., Tischler, A., Grizzle, W.E., Sexton, K.C., Kastl, A., Henderson, J., Porten, S., Waldmann, J., Fassnacht, M., Asa, S.L., Schadendorf, D., Couce, M., Graefen, M., Huland, H., Sauter, G., Schlomm, T., Simon, R., Tennstedt, P., Olabode, O., Nelson, M., Bathe, O., Carroll, P.R., Chan, J.M., Disaia, P., Glenn, P., Kelley, R.K., Landen, C.N., Phillips, J., Prados, M., Simko, J., Smith-McCune, K., VandenBerg, S., Roggin, K., Fehrenbach, A., Kendler, A., Sifri, S., Steele, R., Jimeno, A., Carey, F., Forgie, I., Mannelli, M., Carney, M., Hernandez, B., Campos, B., Herold-Mende, C., Jungk, C., Unterberg, A., von Deimling, A., Bossler, A., Galbraith, J., Jacobus, L., Knudson, M., Knutson, T., Ma, D., Milhem, M., Sigmund, R., Godwin, A.K., Madan, R., Rosenthal, H.G., Adebamowo, C., Adebamowo, S.N., Boussioutas, A., Beer, D., Giordano, T., Mes-Masson, A.M., Saad, F., Bocklage, T., Landrum, L., Mannel, R., Moore, K., Moxley, K., Postier, R., Walker, J., Zuna, R., Feldman, M., Valdivieso, F., Dhir, R., Luketich, J., Pinero, EMM, Quintero-Aguilo, M., Carlotti, C.G., Dos Santos, J.S., Kemp, R., Sankarankuty, A., Tirapelli, D., Catto, J., Agnew, K., Swisher, E., Creaney, J., Robinson, B., Shelley, C.S., Godwin, E.M., Kendall, S., Shipman, C., Bradford, C., Carey, T., Haddad, A., Moyer, J., Peterson, L., Prince, M., Rozek, L., Wolf, G., Bowman, R., Fong, K.M., Yang, I., Korst, R., Rathmell, W.K., Fantacone-Campbell, J.L., Hooke, J.A., Kovatich, A.J., Shriver, C.D., DiPersio, J., Drake, B., Govindan, R., Heath, S., Ley, T., Van Tine, B., Westervelt, P., Rubin, M.A., Lee, J.I., Aredes, N.D., Mariamidze, A.

Source: Cell, 173(2), 321. Cell Press
Sanchez-Vega, Francisco; Mina, Marco; Armenia, Joshua; Chatila, Walid K; Luna, Augustin; La, Konnor C; Dimitriadoy, Sofia; Liu, David L; Kantheti, Havish S; Saghafinia, Sadegh; Chakravarty, Debyani; Daian, Foysal; Gao, Qingsong; Bailey, Matthew H; Liang, Wen-Wei; Foltz, Steven M; Shmulevich, Ilya; Ding, Li; Heins, Zachary; Ochoa, Angelica; ... (2018). Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell, 173(2), 321-337.e10. Cell Press 10.1016/j.cell.2018.03.035 <http://dx.doi.org/10.1016/j.cell.2018.03.035>
337.e10
Cell
Cell, vol. 173, no. 2, pp. 321-337.e10

Subject Terms: cancer genome atlas, cancer genomics, combination therapy, pan-cancer, PanCanAtlas, precision oncology, signaling pathways, TCGA, therapeutics, whole exome sequencing, Biochemistry, Genetics and Molecular Biology(all), Article, 610 Medicine & health, Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, COMPREHENSIVE MOLECULAR CHARACTERIZATION, LANDSCAPE, GENES, EXPRESSION, SIGNATURES, MUTATIONS, Databases, Genetic, Genes, Neoplasm, Humans, Neoplasms, Phosphatidylinositol 3-Kinases, Signal Transduction, Transforming Growth Factor beta, Tumor Suppressor Protein p53, Wnt Proteins, Cancer Genome Atlas Research Network, 06 Biological Sciences, 11 Medical and Health Sciences, Developmental Biology, Biochemistry, Genetics and Molecular Biology(all), Pan-cancer, Signaling pathways, Whole exome sequencing, Combination therapy, Cancer genome atlas, Cancer genomics, Precision oncology, whole exome sequencin, Settore MED/27 - Neurochirurgia, General Biochemistry, Genetics and Molecular Biology, Biology, Cancer research, Transforming growth factor beta, biology.protein, Cell cycle, Gene, Cancer, medicine.disease, medicine, Wnt signaling pathway, DNA methylation, Somatic cell, Protein kinase B, Neoplasms/genetics, Neoplasms/pathology, Phosphatidylinositol 3-Kinases/genetics, Phosphatidylinositol 3-Kinases/metabolism, Signal Transduction/genetics, Transforming Growth Factor beta/genetics, Transforming Growth Factor beta/metabolism, Tumor Suppressor Protein p53/genetics, Tumor Suppressor Protein p53/metabolism, Wnt Proteins/genetics, Wnt Proteins/metabolism

File Description: image/pdf; application/pdf; ELETTRONICO

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7bd5babae899051cba8e4370f28d5e
https://dspace.library.uu.nl/handle/1874/363899

10

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

Authors: Roberto Cuttano, Elisabetta Dejana, Monica Corada, Mukesh Mk Jain, Martin A. Schwartz, Maria Grazia Lampugnani, Luigi Maddaluno, Costanza Giampietro, Nicolas Baeyens, Eleanna Papa, Noemi Rudini, Gary Owens, Luca Bravi, Marco Francesco Morini, Ralf H. Adams

Source: EMBO Molecular Medicine
EMBO Molecular Medicine, 8 (1)
Cuttano, R, Rudini, N, Bravi, L, Corada, M, Giampietro, C, Papa, E, Morini, M F, Maddaluno, L, Baeyens, N, Adams, R H, Jain, M K, Owens, G K, Schwartz, M, Lampugnani, M G & Dejana, E 2016, ' KLF4 is a key determinant in the development and progression of cerebral cavernous malformations ', EMBO Molecular Medicine, vol. 8, no. 1, PMID 26612856, pp. 6-24 . https://doi.org/10.15252/emmm.201505433
EMBO molecular medicine, 8 (1

Subject Terms: Research Article, Research Articles, CCM, EndMT, endothelial cells, KLF4, TGFβ‐BMP, Cardiovascular System, Genetics, Gene Therapy & Genetic Disease, Vascular Biology & Angiogenesis, TGF beta-BMP, Basic Medicine, Medicinska och farmaceutiska grundvetenskaper, Molecular Medicine, Biology, Transforming growth factor beta, biology.protein, Bone morphogenetic protein 6, Signal transduction, Cancer research, Phenotype, HEK 293 cells, Bone morphogenetic protein, Central nervous system, medicine.anatomical_structure, medicine, Endothelial cells, TGFβ-BMP, Sciences bio-médicales et agricoles, Animals, Bone Morphogenetic Protein 6 -- antagonists & inhibitors -- genetics -- metabolism, Cell Proliferation, Disease Models, Animal, Disease Progression, Endothelial Cells -- cytology -- metabolism, HEK293 Cells, Hemangioma, Cavernous, Central Nervous System -- genetics -- metabolism -- pathology, Humans, Kruppel-Like Transcription Factors -- antagonists & inhibitors -- genetics -- metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Microtubule-Associated Proteins -- antagonists & inhibitors -- genetics -- metabolism, Mitogen-Activated Protein Kinase 7 -- metabolism, Mutation, Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism, RNA Interference, Signal Transduction, Smad1 Protein -- metabolism, Transforming Growth Factor beta -- metabolism, Settore MED/04 - Patologia Generale, embryonic structures

File Description: application/pdf; application/application/pdf; 1 full-text file(s): application/pdf

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http://europepmc.org/articles/PMC4718159

11

CD4+CD25−mTGFβ+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma

Authors: François Spertini, Constance Barazzone Argiroffo, Caroline Boudousquié, Yves Donati, Catherine Barbey, Céline Pellaton-Longaretti, Alain Sauty, Nathalie Barbier

Source: International Immunology, Vol. 23, No 1 (2011) pp. 17-27
International Immunology, vol. 23, no. 1, pp. 17-27

Subject Terms: ddc:616.07, ddc:618, Administration, Intranasal, Allergens/administration & dosage/immunology, Animals, Asthma/immunology/therapy, Bronchoalveolar Lavage Fluid/immunology, CD4-Positive T-Lymphocytes/immunology, Cell Proliferation, Cytokines/biosynthesis, Desensitization, Immunologic/methods, Drug Evaluation, Preclinical, Immune Tolerance, Interleukin-2 Receptor alpha Subunit/metabolism, Lung/immunology, Lymph Nodes/immunology, Mice, Mice, Inbred BALB C, Ovalbumin/administration & dosage/immunology, T-Lymphocytes, Regulatory/immunology, Th1 Cells/immunology/metabolism, Th2 Cells/immunology, Transforming Growth Factor beta/metabolism, Immunology, General Medicine, Immunology and Allergy, IL-2 receptor, Nasal administration, Interleukin 10, Tolerance induction, Ovalbumin, biology.protein, biology, Allergen, medicine.disease_cause, medicine, business.industry, business, Immunotherapy, medicine.medical_treatment, Cytokine, respiratory system, respiratory tract diseases

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http://doc.rero.ch/record/295192/files/dxq453.pdf

12

TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells

Authors: Fricke, Fabia, Lee, Jennifer, Michalak, Malwina, Warnken, Uwe, Haußer, Ingrid, Suarez-Carmona, Meggy, Halama, Niels, Schnölzer, Martina, Kopitz, Jürgen, Gebert, Johannes

Source: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-14 (2017)
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Communication and Signaling, 15(1), 14., United Kingdom. (2017).

Subject Terms: Cell Biology, Molecular Biology, Biochemistry, Phenotype, Cancer research, Transforming growth factor beta, biology.protein, biology, Microsatellite instability, medicine.disease, medicine, Frameshift mutation, DNA mismatch repair, Suppressor, law.invention, law, Microvesicles, Platelet-derived growth factor, chemistry.chemical_compound, chemistry, Research, Exosomes, Intercellular communication, Proteomics, Transforming Growth Factor Beta Receptor Type 2, DNA mismatch repair deficiency, Colorectal cancer, lcsh:Medicine, lcsh:R, lcsh:Cytology, lcsh:QH573-671, Chemokines/metabolism, Colorectal Neoplasms/metabolism, DNA Mismatch Repair, Enzyme-Linked Immunosorbent Assay, Exosomes/metabolism/ultrastructure, Frameshift Mutation/genetics, HCT116 Cells, Hep G2 Cells, Humans, Microsatellite Instability, Platelet-Derived Growth Factor/metabolism, Protein-Serine-Threonine Kinases/metabolism, Proteome/metabolism, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta/metabolism, Reproducibility of Results, Oncology [Human health sciences], Oncologie [Sciences de la santé humaine], 610 Medical sciences Medicine, digestive system diseases

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13

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Contributors: PMB medici

Source: Nature, 508(7494), 118-22. Nature Publishing Group

Subject Terms: Animals, Antineoplastic Agents/administration & dosage, Cell Proliferation/drug effects, Cellular Senescence/drug effects, Drug Resistance, Neoplasm/drug effects, ErbB Receptors/biosynthesis, Female, Flow Cytometry, Gene Expression Regulation, Neoplastic/drug effects, Gene Library, Humans, Indoles/administration & dosage, Melanoma/drug therapy, Mice, Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors, Protein Kinase Inhibitors/administration & dosage, Proto-Oncogene Proteins B-raf/antagonists & inhibitors, RNA, Small Interfering, Receptor Protein-Tyrosine Kinases/biosynthesis, Receptor, Platelet-Derived Growth Factor beta/biosynthesis, SOXE Transcription Factors/deficiency, Signal Transduction/drug effects, Sulfonamides/administration & dosage, Transforming Growth Factor beta/metabolism, Vemurafenib, Multidisciplinary, Drug resistance, V600E, Cancer research, Small hairpin RNA, Biology, medicine.drug, medicine, Growth factor receptor, Melanoma, medicine.disease, PDGFRB, Epidermal growth factor receptor, biology.protein, Drug Resistance, Neoplasm/drug effects, Gene Expression Regulation, Neoplastic/drug effects, RNA, Small Interfering, Receptor, Platelet-Derived Growth Factor beta/biosynthesis, neoplasms

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14

Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis

Authors: Jonathan Melquist, Giovanni Nitti, Tiewei Cheng, Colin P. Dinney, Woonyoung Choi, Sima P. Porten, David J. McConkey, Isuru Jayaratna, Bogdan Czerniak, Debasish Sundi, Charles C. Guo, Matthew F. Wszolek, Neema Navai, Beat Roth

Source: Oncotarget, vol. 8, no. 21, pp. 34205-34222
Roth, Beat; Jayaratna, Isuru; Sundi, Debasish; Cheng, Tiewei; Melquist, Jonathan; Choi, Woonyoung; Porten, Sima; Nitti, Giovanni; Navai, Neema; Wszolek, Matthew; Guo, Charles; Czerniak, Bogdan; McConkey, David; Dinney, Colin (2017). Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. OncoTarget, 8(21), pp. 34205-34222. Impact Journals LLC 10.18632/oncotarget.11009 <http://dx.doi.org/10.18632/oncotarget.11009>
Oncotarget

Subject Terms: 610 Medicine & health, Animals, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Epithelial-Mesenchymal Transition, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Metastasis, Neoplastic Cells, Circulating/metabolism, Neoplastic Cells, Circulating/pathology, Signal Transduction/drug effects, Snail Family Transcription Factors/genetics, Snail Family Transcription Factors/metabolism, Transforming Growth Factor beta/genetics, Transforming Growth Factor beta/metabolism, Urinary Bladder Neoplasms/genetics, Urinary Bladder Neoplasms/metabolism, Urinary Bladder Neoplasms/pathology, Whole Genome Sequencing, SNAIL, bladder cancer, circulating tumor cells, metastasis, orthotopic xenografts, Research Paper, Oncology, Transforming growth factor beta, biology.protein, biology, Gene silencing, Primary tumor, medicine.disease, medicine, Epithelial–mesenchymal transition, Bladder cancer, Snail, biology.animal, Circulating tumor cell, business.industry, business, Metastasis, Pathology, medicine.medical_specialty

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15

Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease

Authors: Jakob Benedict Seidelin, Xiaolei Yin, Jeffrey M. Karp, Yuan Li, Zhixiang Tong, Fredrik Eo Holmberg, Ole Haagen Nielsen, Benjamin E. Mead

Source: Holmberg, F E, Seidelin, J B, Yin, X, Mead, B E, Tong, Z, Li, Y, Karp, J M & Nielsen, O H 2017, ' Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease ', EMBO Molecular Medicine, vol. 9, no. 5, pp. 558-570 . https://doi.org/10.15252/emmm.201607260
EMBO Molecular Medicine

Subject Terms: Review, inflammatory bowel disease, intestinal stem cells, organoids, regenerative medicine, support matrix, Digestive System, Immunology, Stem Cells, Animals, Bone Morphogenetic Proteins/metabolism, Cell Culture Techniques/methods, Culture Media/chemistry, Dinoprostone/metabolism, Epidermal Growth Factor/metabolism, Humans, Inflammatory Bowel Diseases/metabolism, Intestines/cytology, Receptors, Notch/metabolism, Regeneration, Regenerative Medicine/methods, Signal Transduction, Stem Cell Transplantation/methods, Stem Cells/cytology, Tissue Scaffolds/chemistry, Transforming Growth Factor beta/metabolism, Wnt Signaling Pathway, Journal Article, Molecular Medicine, Barrier function, Population, education.field_of_study, education, Transplantation, Biology, Organoid, Regenerative medicine, Stem cell, Clinical uses of mesenchymal stem cells, Inflammatory bowel disease, medicine.disease, medicine, Reviews

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029893

16

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections

Source: Genetics in Medicine, 19, 386-395
Genetics in medicine, vol. 19, no. 4, pp. 386-395
Genetics in Medicine
Genetics in medicine

Subject Terms: Genetics(clinical), Biglycan, Dissection, Marfan syndrome, medicine.disease, medicine, Mutation, medicine.disease_cause, Thoracic aortic aneurysm, Aortic aneurysm, Pathology, medicine.medical_specialty, Loeys–Dietz syndrome, Aneurysm, business.industry, business, Aneurysm, Dissecting/genetics, Aneurysm, Dissecting/metabolism, Aortic Aneurysm, Thoracic/genetics, Aortic Aneurysm, Thoracic/metabolism, Biglycan/genetics, Biglycan/metabolism, Cells, Cultured, Female, Genes, X-Linked, Genetic Predisposition to Disease, Humans, Male, Pedigree, Sequence Analysis, DNA/methods, Signal Transduction, Transforming Growth Factor beta/metabolism, Original Research Article, biglycan, BGN, Loeys-Dietz syndrome, thoracic aortic aneurysm, Human medicine

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17

LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth

Authors: Sarah E. Millar, Ralf Paus, Claus Scheidereit, Ruth Schmidt-Ullrich, Philip Tomann

Source: Tomann, P, Paus, R, Millar, S E, Scheidereit, C & Schmidt-Ullrich, R 2016, ' Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth ', Development (Cambridge, England), vol. 143, no. 9, pp. 1512-22 . https://doi.org/10.1242/dev.130898

Subject Terms: Developmental Biology, Molecular Biology, Morphogenesis, Gene expression, Cancer research, Homeobox, Phenotype, Hair follicle, medicine.anatomical_structure, medicine, Wnt signaling pathway, Biology, Cellular differentiation, Transcription factor, Animals, Cadherins/metabolism, Cell Differentiation/genetics, Cell Movement/genetics, Embryo, Mammalian/metabolism, Gene Expression Regulation, Developmental/genetics, Hair Follicle/embryology, LIM-Homeodomain Proteins/genetics, Mice, Mice, Knockout, Organ Culture Techniques, Organogenesis/genetics, Receptors, Transforming Growth Factor beta/metabolism, Transcription Factor RelA/genetics, Transcription Factors/genetics, Transforming Growth Factor beta2/genetics, Research Article, embryonic structures

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https://syndication.highwire.org/content/doi/10.1242/dev.130898

18

Simultaneous imaging of blood flow dynamics and vascular remodelling during development

Authors: Ghaffari, Siavash, Leask, Richard L, Jones, Elizabeth A V

Source: Development, 142(23), 4158-67. Company of Biologists Ltd

File Description: Print-Electronic; application/pdf

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19

BAMBI elimination enhances alternative TGF-beta signaling and glomerular dysfunction in diabetic mice

Authors: Nicolas Guillot, Niansong Wang, Detlef Schlöndorff, Xuezhu Li, Margaret H. Baron, Ying Fan, Wenzhen Xiao, Maja T. Lindenmeyer, Peter Y. Chuang, Kyung Lee, Jia Fu, Clemens D. Cohen, John C. He, Raymond C. Harris

Contributors: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Vanderbilt University School of Medicine [Nashville], University hospital of Zurich [Zurich], Sixth Affiliated People’s Hospital, Shanghai Jiao Tong University

Source: Diabetes
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2220-33. ⟨10.2337/db14-1397⟩
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2220-2233. ⟨10.2337/db14-1397⟩

Subject Terms: Humans, Animals, Mice, Blotting, Western, In Vitro Techniques, Membrane Proteins/genetics/*metabolism, Angiopoietin-1/genetics/metabolism, Kidney Glomerulus/*metabolism/pathology, Signal Transduction/physiology, Smad1 Protein/genetics/metabolism, Smad5 Protein/genetics/metabolism, Transforming Growth Factor beta/*metabolism, Vascular Endothelial Growth Factor Receptor-2/genetics/metabolism, [SDV]Life Sciences [q-bio], Complications, Endocrinology, Diabetes and Metabolism, Internal Medicine, Chemistry, Internal medicine, medicine.medical_specialty, medicine, Kinase insert domain receptor, Endocrinology, Endothelial dysfunction, medicine.disease, MEK inhibitor, Diabetic nephropathy, Transforming growth factor beta, biology.protein, biology, MAPK/ERK pathway, Cell biology, BAMBI, Downregulation and upregulation

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcedf278915b3839c29db19680ebe33
https://hal.archives-ouvertes.fr/hal-01850503

20

Myofibroblastic stromal reaction and lymph node status in invasive breast carcinoma: possible role of the TGF-β1/TGF-βR1 pathway

Authors: Jean Christophe Noël, Philippe Simon, Xavier Catteau

Source: BMC cancer, 14 (1
BMC Cancer

Subject Terms: Cancer Research, Genetics, Oncology, Lymph node, medicine.anatomical_structure, medicine, Stromal cell, Pathology, medicine.medical_specialty, Tumor microenvironment, Metastasis, medicine.disease, Breast cancer, business.industry, business, Breast carcinoma, CD34, SMA, Cancérologie, Biologie, Actins -- metabolism, Adult, Aged, Aged, 80 and over, Antigens, CD34 -- metabolism, Breast Neoplasms -- metabolism -- pathology, Carcinoma, Ductal, Breast -- metabolism -- pathology, Female, Humans, Lymphatic Metastasis -- pathology, Middle Aged, Myofibroblasts -- cytology -- metabolism -- pathology, Protein-Serine-Threonine Kinases -- metabolism, Receptors, Transforming Growth Factor beta -- metabolism, Signal Transduction, Stromal Cells -- metabolism -- pathology, Transforming Growth Factor beta1 -- metabolism, Tumor Microenvironment, Fibrocytes, Myofibroblasts, TGF-ß, Research Article

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http://link.springer.com/content/pdf/10.1186/1471-2407-14-499.pdf

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