Showing 1 - 20 results of 116 for search '"RNA, Small Interfering genetics"', query time: 1.17s Refine Results
1
Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

Authors: Holm, Anja, Hansen, Stine N., Klitgaard, Henrik, Kauppinen, Sakari

Source: Holm, A, Hansen, S N, Klitgaard, H & Kauppinen, S 2022, ' Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases ', RNA Biology, vol. 19, no. 1, pp. 594-608 . https://doi.org/10.1080/15476286.2022.2066334

Subject Terms: Cell Biology, Molecular Biology, Amyloid Neuropathies, Familial, Amyotrophic Lateral Sclerosis/genetics, Animals, Neuromuscular Diseases/drug therapy, Oligonucleotides, Antisense/genetics, Quality of Life, RNA, Messenger, RNA, Small Interfering/genetics, United States

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https://doi.org/10.1080/15476286.2022.2066334

3
Effective Transfection and Gene Silencing of Primary Murine Macrophages with Small Interfering RNA

Authors: van Kuijk, Kim, Nagenborg, Jan, Sluimer, Judith C, Ramji, Dipak

Contributors: RS: Carim - B07 The vulnerable plaque: makers and markers, Pathologie

Source: Atherosclerosis: Methods and Protocols, 125-132
ISSUE=1;STARTPAGE=125;ENDPAGE=132;TITLE=Atherosclerosis
Methods in Molecular Biology ISBN: 9781071619230

Subject Terms: Animals, Gene Silencing, Macrophages/metabolism, Mice, RNA Interference, RNA, Small Interfering/genetics, Transfection, RNA, Small Interfering/genetics

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https://cris.maastrichtuniversity.nl/en/publications/eb9dfd4c-767a-4ddf-bf63-946a3c49e1b8

4
Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation

Authors: Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie

Source: Journal of Cell Biology, 220(9). Rockefeller University Press
The Journal of Cell Biology

Subject Terms: Actin Cytoskeleton/metabolism, Actins/genetics, Adaptor Proteins, Signal Transducing/genetics, Amino Acid Sequence, Binding Sites, Cell Line, Tumor, Cell Movement, Cloning, Molecular, Cytoskeletal Proteins/genetics, Escherichia coli/genetics, Gene Expression, Gene Expression Regulation, Genetic Vectors/chemistry, Humans, Membrane Proteins/genetics, Models, Molecular, Molecular Chaperones/antagonists & inhibitors, Osteoblasts/cytology, Protein Binding, Protein Conformation, alpha-Helical, Protein Multimerization, Pseudopodia/metabolism, RNA, Small Interfering/genetics, Recombinant Proteins/chemistry, Signal Transduction, Talin/genetics, macromolecular substances, animal structures, embryonic structures, QH301, Report, Adhesion, Cytoskeleton, Structural Biology, Biochemistry, biological phenomena, cell phenomena, and immunity, environment and public health, Cell Biology, Biology, Mechanosensitive channels, Integrin, biology.protein, Cell migration, Antiparallel (biochemistry), Signal transducing adaptor protein, Actin, Filopodia, Cell biology, Adaptor Proteins, Signal Transducing/genetics, Cell Line, Tumor, Cloning, Molecular, Models, Protein Conformation, alpha-Helical, RNA, Small Interfering/genetics, Science & Technology, Life Sciences & Biomedicine, VINCULIN-BINDING, ADHESION, REVEALS, IDENTIFICATION, RECOGNITION, FEATURES, IMAGE, MOTIF, RIAM

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https://dspace.library.uu.nl/handle/1874/414190

7
Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

Authors: Germano Cecere, Giorgia Barucci, Martino Ugolini, Blaise Li, Aleksei Samolygo, Piergiuseppe Quarato, Florent Dingli, Céline Didier, Eric Cornes, Damarys Loew, Meetali Singh

Contributors: Mécanismes de l'Hérédité épigénétique / Mechanisms of epigenetic inheritance, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Scuola Normale Superiore di Pisa (SNS), Moscow Institute of Physics and Technology [Moscow] (MIPT), Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie [Paris], This project has received funding from the Institut Pasteur, the CNRS and the European Research Council (ERC) under the EU Horizon 2020 research and innovation programme under grant agreement no. ERC-StG- 679243. G.B. is part of the Pasteur–Paris University (PPU) International PhD Program and has received funding from the EU Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 665807. E.C. was supported by a Pasteur-Cantarini Fellowship program. F.D. and D.L. have received funding from Région Ile-de-France and Fondation pour la Recherche Médicale grants to support this study, We thank the members of the Cecere laboratory, D. Canzio, N. Iovino, R. Sawarkar and P. Andersen for discussions of the manuscript, the Miska, the Mello, the Kennedy, the Seydoux, the Claycomb, the Strome and the Dumont laboratories for sharing strains and/or antibodies. Some strains were provided by the CGC, funded by NIH Office of Research Infrastructure Programs (P40 OD010440)., Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]

Source: Nature Cell Biology
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature cell biology

Subject Terms: Cell Biology, Gene silencing, Gene, Piwi-interacting RNA, Mutation, medicine.disease_cause, medicine, Cell biology, RNA, Histone, biology.protein, biology, Caenorhabditis elegans, biology.organism_classification, Small RNA, endocrine system, urogenital system, Epigenetic memory, Piwi RNAs, RNAi, MESH: Animals, MESH: Animals, Genetically Modified, MESH: RNA, Antisense / genetics, MESH: RNA, Antisense / metabolism, MESH: Argonaute Proteins / deficiency, MESH: RNA, Messenger / genetics, MESH: RNA, Messenger / metabolism, MESH: RNA, Small Interfering / genetics, MESH: RNA, Small Interfering / metabolism, MESH: Repetitive Sequences, Nucleic Acid, MESH: Argonaute Proteins / genetics, MESH: Argonaute Proteins / metabolism, MESH: Caenorhabditis elegans Proteins / metabolism, MESH: Biological Evolution, MESH: CRISPR-Cas Systems, MESH: Caenorhabditis elegans / genetics, MESH: Caenorhabditis elegans / metabolism, MESH: Caenorhabditis elegans Proteins / genetics, MESH: Fertility / genetics, MESH: Gene Editing, MESH: Gene Silencing, MESH: Histones / genetics, MESH: Histones / metabolism, MESH: Inheritance Patterns, MESH: Mutation, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Article

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https://doi.org/10.1038/s41556-020-0462-7

8
Defining the functions of PIWI-interacting RNAs

Authors: Wu, Pei-Hsuan, Zamore, Phillip D

Source: Nature reviews. Molecular cell biology, Vol. 22, No 4 (2021) pp. 239-240

Subject Terms: Animals, DNA Transposable Elements / genetics, Gene Expression / genetics, Humans, RNA / genetics, RNA, Small Interfering / genetics

Access URL: https://explore.openaire.eu/search/publication?articleId=od______1400::1007e149b2bb41b6ba4c38b7e0ab0f0c
https://archive-ouverte.unige.ch/unige:160560

9
Development of siRNA Therapeutics for the Treatment of Liver Diseases

Authors: Sakari Kauppinen, Marianne B. Løvendorf, Anja Holm

Contributors: Ditzel, Henrik J., Tuttolomondo, Martina, Kauppinen, Sakari

Source: Holm, A, Løvendorf, M B & Kauppinen, S 2021, Development of siRNA Therapeutics for the Treatment of Liver Diseases . in H J Ditzel, M Tuttolomondo & S Kauppinen (eds), Design and Delivery of SiRNA Therapeutics . vol. 2282, Springer, Methods in Molecular Biology, vol. 2282, pp. 57-75 . https://doi.org/10.1007/978-1-0716-1298-9_5
Methods in Molecular Biology ISBN: 9781071612972

Subject Terms: Acetylgalactosamine/analogs & derivatives, Amyloid Neuropathies, Familial/genetics, Animals, Gene Transfer Techniques, Humans, Liver Diseases/genetics, Porphyrias, Hepatic/diagnosis, Pyrrolidines/therapeutic use, RNA Interference, RNA, Small Interfering/genetics, RNAi Therapeutics, Transthyretin, biology.protein, biology, RNA interference, Cancer research, Gene silencing, Acute hepatic porphyria, Medicine, business.industry, business, Small interfering RNA

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https://vbn.aau.dk/da/publications/e13cc44c-a30e-4239-a6c6-ff8695e8c49b

10
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Authors: Henriette Pedersen, Rikke Darling Rasmussen, Jannick Brennum, Jiri Bartek, Christoffel Dinant, Jane Skjøth-Rasmussen, Petra Hamerlik, Robert Strauss, Elisabeth Anne Adanma Obara, Kirstine Juul Elbæk, Yi Chieh Lim, Lucie Tučková, Lina Vardouli, Kristoffer Vitting-Serup, Diana Aguilar-Morante, Kamilla E. Jensen, Alex Frias

Source: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Obara, E A A, Aguilar-Morante, D, Rasmussen, R D, Frias, A, Vitting-Serup, K, Lim, Y C, Elbæk, K J, Pedersen, H, Vardouli, L, Jensen, K E, Skjoth-Rasmussen, J, Brennum, J, Tuckova, L, Strauss, R, Dinant, C, Bartek, J & Hamerlik, P 2020, ' SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells ', Nature Communications, vol. 11, 4709 . https://doi.org/10.1038/s41467-020-18549-8

Subject Terms: Article, Cancer stem cells, Homologous recombination, endocrine system, fungi, lcsh:Science, lcsh:Q, Animals, Apoptosis, BRCA1 Protein, Brain Neoplasms/genetics, Cell Cycle Checkpoints, Cell Line, Tumor, DNA Repair, Female, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Gene Silencing, Genomic Instability, Glioblastoma/genetics, HEK293 Cells, Heterografts, Humans, Mice, Mice, Inbred BALB C, Neoplastic Stem Cells/pathology, RNA, Small Interfering/genetics, Radiation Tolerance, Radiation, Ionizing, Transcription Factors/genetics, Transcriptome, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary, Chromatin, Gene silencing, Chromatin remodeling, Biology, Regulation of gene expression, DNA, chemistry.chemical_compound, chemistry, DNA repair, Cell biology, Genome instability, Science

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http://europepmc.org/articles/PMC7501306

11
CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS- and STING-dependent Maturation

Authors: Ralf Agger, Marlene Fyrstenberg Laursen, Laura L. T. Degn, Kasper L Jønsson, Esben Christensen, Martin R. Jakobsen, Emil Kofod-Olsen

Source: Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS-and STING-dependent Maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted delivery of DNA to dendritic cells leads to cGAS-and STING-dependent maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195

Subject Terms: Cancer Research, Pharmacology, Immunology, Immunology and Allergy, CD11c, Endocytosis, Cell biology, Cell Maturation, THP1 cell line, Cancer cell, Ionomycin, chemistry.chemical_compound, chemistry, Cellular differentiation, Downregulation and upregulation, Antibody-Targeting, cGAS, DC maturation, STING, Journal Article, CD11c Antigen/metabolism, Nucleotidyltransferases/genetics, Programmed Cell Death 1 Receptor/immunology, Immunotherapy/methods, Humans, RNA, Small Interfering/genetics, Membrane Proteins/genetics, THP-1 Cells, Antibodies, Monoclonal/therapeutic use, Dendritic Cells/physiology, CTLA-4 Antigen/immunology, DNA/immunology, B7-H1 Antigen/immunology, Neoplasms/immunology, Cell Differentiation, Cytokines/metabolism

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https://doi.org/10.1097/cji.0000000000000195

12
The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity

Authors: Dominique Goudounèche, Sophie Allart, Michel Simon, Alain Moga, Marie Reynier, Corinne Leprince, Guy Serre

Contributors: Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Microscopie Électronique Appliquée à la Biologie (CMEAB), Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Toulouse Réseau Imagerie-Genotoul ( TRI-Genotoul), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), SYNELVIA, Toulouse Réseau Imagerie-Genotoul ( TRI-Genotoul)

Source: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩

Subject Terms: MESH: Actin Cytoskeleton / metabolism, MESH: Actins / metabolism, MESH: Tight Junctions / metabolism, MESH: rab GTP-Binding Proteins / metabolism, MESH: Cells, Cultured, MESH: Claudin-1 / metabolism, MESH: Epidermis / metabolism, MESH: Epidermis / pathology, MESH: Humans, MESH: Intercellular Signaling Peptides and Proteins / metabolism, MESH: Keratinocytes / metabolism, MESH: Keratinocytes / pathology, MESH: Myosin Heavy Chains / genetics, MESH: Myosin Heavy Chains / metabolism, MESH: Myosin Type V / genetics, MESH: Myosin Type V / metabolism, MESH: Protein Binding, MESH: Protein Transport, MESH: RNA, Small Interfering / genetics, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, integumentary system, Cell Biology, Dermatology, Molecular Biology, Biochemistry, Actin, Lamellar granule, Stratum corneum, medicine.anatomical_structure, medicine, Cytoskeleton, Cell biology, Epidermis, Chemistry, Golgi apparatus, symbols.namesake, symbols, Myosin, Cell junction

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b23279e57f8e5cb9731c489548ae9e
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03156416

13
Mitochondrial stress response triggered by defects in protein synthesis quality control

Authors: Anne Lombès, Cecilia Mancini, Fumi Suomi, Tuula A. Nyman, Robert W. Taylor, Paula Marttinen, Anu Suomalainen, Taina Turunen, Brendan J. Battersby, Kah Ying Ng, Christopher B. Jackson, Marita A Isokallio, Alfredo Brusco, James B. Stewart, Eija Jokitalo, Sara Seneca, Helena Vihinen, Uwe Richter

Contributors: Institute of Biotechnology, University of Helsinki, Research Programs Unit, Anu Wartiovaara / Principal Investigator, STEMM - Stem Cells and Metabolism Research Program, HUSLAB, Department of Neurosciences, University Management, Electron Microscopy, Clinical sciences, Reproduction and Genetics, Medical Genetics

Source: Life Science Alliance
Life Sci Alliance

Subject Terms: M-AAA PROTEASE, COMPUTATIONAL PLATFORM, SPASTIC PARAPLEGIA, READ ALIGNMENT, DNA DELETIONS, MUTATIONS, OPA1, MEMBRANE, ATAXIA, TURNOVER, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology, mitochondria, AFG3L2, protein synthesis, inner mitochondrial membrane, chloramphenicol, Health, Toxicology and Mutagenesis, Plant Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), Ecology, Inner mitochondrial membrane, Chemistry, Protein biosynthesis, Mitochondrial ribosome, Membrane protein, Paraplegin, Oxidative phosphorylation, Mitochondrial matrix, Mitochondrion, Cell biology, Research Article, Research Articles, ATP-Dependent Proteases/genetics, ATPases Associated with Diverse Cellular Activities/genetics, Animals, Fibroblasts/metabolism, GTP Phosphohydrolases/metabolism, Gene Knockdown Techniques, HEK293 Cells, Humans, Metalloendopeptidases/metabolism, mice, Mitochondria/metabolism, Mitochondrial Membranes/metabolism, Mitochondrial Proteins/biosynthesis, Mitochondrial Ribosomes/metabolism, mutation, Phenotype, Protein Biosynthesis, RNA, Messenger/genetics, RNA, Small Interfering/genetics, Transfection, reproductive medicine, Biochemistry, Genetics and Molecular Biology(all), Genetics(clinical)

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb791ad5c28fb97e1358e6dbc9a5d10f
http://hdl.handle.net/10138/307109

14
Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Authors: Patrycja Nowak-Sliwinska, Axel Bex, Judy R. van Beijnum, Laurie A. Mans, Elisabeth J. M. Huijbers, Arjan W. Griffioen, Paula C Gasull

Contributors: Medical oncology laboratory, CCA - Cancer biology and immunology

Source: Nowak-Sliwinska, P, van Beijnum, J R, Huijbers, E J M, Gasull, P C, Mans, L, Bex, A & Griffioen, A W 2019, ' Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment ', British Journal of Cancer, vol. 120, no. 2, pp. 218-228 . https://doi.org/10.1038/s41416-018-0347-8
British Journal of Cancer, Vol. 120, No 2 (2019) pp. 218-228
British Journal of Cancer
British Journal of Cancer, 120(2), 218-228. Nature Publishing Group

Subject Terms: endocrine system, nutritional and metabolic diseases, hormones, hormone substitutes, and hormone antagonists, ddc:615, Animals, Antigens, CD/genetics, Cell Proliferation/genetics, Chick Embryo, Chorioallantoic Membrane/metabolism/pathology, Disease Models, Animal, Endothelium/metabolism/pathology, Female, Gene Knockdown Techniques, Genome, Human/genetics, Human Umbilical Vein Endothelial Cells, Humans, Insulin/genetics/metabolism, Kidney Neoplasms/genetics/pathology, Male, Mice, Neovascularization, Pathologic/genetics/pathology, Protein Isoforms/genetics, RNA, Small Interfering/genetics, Receptor, Insulin/genetics, Tumor Cells, Cultured, Cancer Research, Oncology, Endothelium, medicine.anatomical_structure, medicine, Insulin receptor, biology.protein, biology, In vivo, business.industry, business, Angiogenesis, Insulin, medicine.medical_treatment, Neovascularization, medicine.symptom, Chorioallantoic membrane, Receptor, Cancer research, Article, Tumour angiogenesis, Targeted therapies

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e807074e8a0b74c159b37017cca3495
https://research.vumc.nl/en/publications/d329b72d-a3ca-4cb4-aa2e-7a449c300c73

15
Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Authors: Alexandra Bezler, Arthur Duplan, Fabio Piano, Eric A. Miska, Laurent Keller, Kristin C. Gunsalus, Pierre Gönczy, Raffaella Conconi, Fabian Braukmann, Sean M. West, Frédéric Schütz

Source: PLoS Genetics, vol. 15, no. 2, pp. e1007905
PLoS Genetics
PLoS Genetics, Vol 15, Iss 2, p e1007905 (2019)

Subject Terms: Animals, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins/genetics, Female, Gene Expression Regulation/genetics, Germ Cells/physiology, Gonads/physiology, High-Throughput Nucleotide Sequencing/methods, Male, MicroRNAs/genetics, RNA Interference/physiology, RNA, Double-Stranded/genetics, RNA, Messenger/genetics, RNA, Small Interfering/genetics, Sex Characteristics, Gene silencing, Regulation of gene expression, Piwi-interacting RNA, Small interfering RNA, Genetics, Biology, RNA interference, Germline, Gene expression, microRNA, double-stranded-rna, functional genomic analysis, binding-protein rde-4, caenorhabditis-elegans, gene-expression, transgenerational inheritance, sirna pathways, germline, micrornas, sperm, Research Article, Biology and life sciences, Gene regulation, Small interfering RNAs, Biochemistry, Nucleic acids, RNA, Non-coding RNA, Anatomy, Reproductive System, Genital Anatomy, Gonads, Medicine and Health Sciences, Epigenetics, Genetic interference, Natural antisense transcripts, Molecular biology, Molecular biology techniques, Sequencing techniques, RNA sequencing, Research and analysis methods, Animal Studies, Experimental Organism Systems, Model Organisms, Caenorhabditis Elegans, Animal Models, Organisms, Eukaryota, Invertebrates, Nematoda, Caenorhabditis, Cell Biology, Cellular Types, Animal Cells, Germ Cells, lcsh:Genetics, lcsh:QH426-470

File Description: application/pdf

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b475513f2390791ae200972535565b
https://serval.unil.ch/notice/serval:BIB_298BFAD57531

16
Contribution of allelic imbalance to colorectal cancer

Authors: Outi Kilpivaara, Johanna Kondelin, Heli Rauanheimo, Tuomo Hartonen, Riku Katainen, Niko Välimäki, Teemu Kivioja, Tomas Tanskanen, Linda van den Berg, Torben F. Ørntoft, Jussi Taipale, Bernhard Schmierer, Anna Vähärautio, Halit Ongen, Ulrika A. Hänninen, Lauri A. Aaltonen, Eevi Kaasinen, Claus L. Andersen, Laura Renkonen-Sinisalo, Päivi Pihlajamaa, Roosa-Maria Plaketti, Tatiana Cajuso, Aurora Taira, Maria Sokolova, Kornelia Gladysz, Sari Tuupanen, Päivi Sulo, Mikko P. Turunen, Kimmo Palin, Jesper B. Bramsen, Anna Lepistö, Mervi Aavikko, Jukka-Pekka Mecklin, Ari Ristimäki, Marta Grau, Biswajyoti Sahu, Kashyap Dave, Sandeep Kumar Botla, Emmanouil T. Dermitzakis, Esa Pitkänen

Contributors: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Doctoral Programme in Integrative Life Science, Centre of Excellence in Stem Cell Metabolism, Nutrient sensing laboratory, Jussi Taipale / Principal Investigator, Institute of Biotechnology, Department of Pathology, HUSLAB, Gastrointestinal tumorigenesis, Clinicum, Doctoral Programme in Clinical Research, Department of Surgery, II kirurgian klinikka, HUS Abdominal Center

Source: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Palin, K, Pitkänen, E, Turunen, M, Sahu, B, Pihlajamaa, P, Kivioja, T, Kaasinen, E, Välimäki, N, Hänninen, U A, Cajuso, T, Aavikko, M, Tuupanen, S, Kilpivaara, O, van den Berg, L, Kondelin, J, Tanskanen, T, Katainen, R, Grau, M, Rauanheimo, H, Plaketti, R-M, Taira, A, Sulo, P, Hartonen, T, Dave, K, Schmierer, B, Botla, S, Sokolova, M, Vähärautio, A, Gladysz, K, Ongen, H, Dermitzakis, E, Bramsen, J B, Ørntoft, T F, Andersen, C L, Ristimäki, A, Lepistö, A, Renkonen-Sinisalo, L, Mecklin, J-P, Taipale, J & Aaltonen, L A 2018, ' Contribution of allelic imbalance to colorectal cancer ', Nature Communications, vol. 9, 3664 . https://doi.org/10.1038/s41467-018-06132-1
Nature Communications, Vol. 9, No 1 (2018) P. 3664

Subject Terms: Article, lcsh:Science, lcsh:Q, colorectal cancer, paksusuolisyöpä, syöpägeenit, mutaatiot, Science, Chromosomes, Human, Pair 8, Humans, Colorectal Neoplasms, Chromosome Aberrations, Genetic Predisposition to Disease, Transcription Factors, RNA, Small Interfering, Gene Expression Profiling, Genomics, Microsatellite Repeats, Genotype, Phenotype, Allelic Imbalance, Loss of Heterozygosity, Point Mutation, Denmark, Tumor Suppressor Protein p53, Proto-Oncogene Proteins p21(ras), DNA Copy Number Variations, CRISPR-Cas Systems, Whole Genome Sequencing, Colorectal Neoplasms/genetics, Proto-Oncogene Proteins p21(ras)/genetics, RNA, Small Interfering/genetics, Transcription Factors/genetics, Tumor Suppressor Protein p53/genetics, HUMAN-COLON, GENOME, CELLS, ENHANCERS, GENES, 3111 Biomedicine, ddc:576.5, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Cancer, medicine.disease, medicine, Genetics, Loss of heterozygosity, Biology, Point mutation, Gene

File Description: application/pdf; fulltext; Electronic

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http://europepmc.org/articles/PMC6131244

17
Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism

Authors: Claudia Maria de Castro Gomes, Gabrielle B L Silva, José Vitorino dos Santos, Ulisses Gazos Lopes, Charlene A S Pinto, Áislan de Carvalho Vivarini, Nicolas Fasel, Karina Luiza Dias-Teixeira, Alessandra Mattos Saliba, Renata M. Pereira, Teresa Cristina Calegari-Silva, Amanda S S Pacheco, Carolina Torturella Rath, Carlos Eduardo Pereira Corbett

Source: European journal of immunology, vol. 48, no. 7, pp. 1188-1198
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Subject Terms: Adolescent, Adult, Cells, Cultured, Child, Extinction, Biological, Female, Histone Deacetylase 1/genetics, Histone Deacetylase 1/metabolism, Host-Parasite Interactions, Humans, Immune Evasion, Leishmania braziliensis/physiology, Leishmaniasis, Cutaneous/genetics, Leishmaniasis, Cutaneous/immunology, Macrophages/immunology, Male, Middle Aged, Nitric Oxide/metabolism, Nitric Oxide Synthase Type II/genetics, Nitric Oxide Synthase Type II/metabolism, Parasite Load, Promoter Regions, Genetic/genetics, Protein Binding, RNA, Small Interfering/genetics, Skin/pathology, Sp1 Transcription Factor/metabolism, Young Adult, HDAC1, Leishmaniasis, Macrophage, Parasitse, animal structures, Immunology, Immunology and Allergy, Intracellular, Gene silencing, Leishmania, biology.organism_classification, biology, Downregulation and upregulation, Gene expression, Molecular biology, Nitric oxide synthase, biology.protein, Nitric oxide, chemistry.chemical_compound, chemistry, CROMATINA

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8ac4e7c7cd8865a82b83be8e071c51
https://serval.unil.ch/notice/serval:BIB_2BD77F8A82A7

18
The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment

Authors: Abhishek Mitra, Giuseppina M. Carbone, Gianluca Civenni, Carlo V. Catapano, Simona Rossi, Domenico Albino

Source: Oncotarget
Oncotarget, vol. 7, no. 47, pp. 76756-76768

Subject Terms: Oncology, Cancer research, Cancer stem cell, Transcription factor, Immunology, STAT3, biology.protein, biology, ETS transcription factor family, Cancer cell, Prostate cancer, medicine.disease, medicine, Prostate, medicine.anatomical_structure, Cancer, Research Paper, ETS transcription factor, ESE3/EHF, IL-6, cancer stem cells, prostate cancer, Cell Line, Tumor, Cell Self Renewal/genetics, Cell Transformation, Neoplastic/genetics, Cell Transformation, Neoplastic/metabolism, Disease Progression, Epithelial-Mesenchymal Transition/genetics, Gene Expression Regulation, Neoplastic, Humans, Interleukin-6/genetics, Interleukin-6/metabolism, Janus Kinase 2/antagonists & inhibitors, Male, Models, Biological, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Phenotype, Promoter Regions, Genetic, Prostatic Neoplasms/genetics, Prostatic Neoplasms/metabolism, Prostatic Neoplasms/pathology, Protein Kinase Inhibitors/pharmacology, RNA Interference, RNA, Small Interfering/genetics, STAT3 Transcription Factor/metabolism, Transcription Factors/metabolism, Transcriptional Activation

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b8ef029518f5f53988142dddb7a1d4
https://doi.org/10.18632/oncotarget.12525

19
PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation

Authors: G. Paolo Dotto, Seung-Hee Jo, Andrea Clocchiatti, Dong-Eun Kim

Source: Oncotarget
Oncotarget, vol. 7, no. 37, pp. 58717-58727

Subject Terms: Priority Research Paper, PDCD4, Notch/CSL signaling, transcription repression, squamous cancer, CAFs, Animals, Apoptosis Regulatory Proteins/genetics, Apoptosis Regulatory Proteins/metabolism, Cancer-Associated Fibroblasts/immunology, Cancer-Associated Fibroblasts/metabolism, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/metabolism, Cell Line, Tumor, Cellular Senescence, Down-Regulation, HEK293 Cells, HeLa Cells, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Keratosis, Actinic/genetics, Keratosis, Actinic/metabolism, Mice, Mice, SCID, Protein Binding, RNA, Small Interfering/genetics, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Signal Transduction, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Transcription, Genetic, Xenograft Model Antitumor Assays, Oncology, Stromal cell, Dermal fibroblast, Signal transduction, Notch signaling pathway, Immunology, Cancer research, Effector, Transcription (biology), Fibroblast, medicine.anatomical_structure, medicine, Carcinogenesis, medicine.disease_cause, Biology

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea12f5aaed1cf56a0d17a8e7fc46ffdd
http://europepmc.org/articles/PMC5312270

20
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Authors: Nadia Raffaelli, Giovanna Bianchi, Mirko Magnone, Aimable Nahimana, Santina Bruzzone, Lizzia Raffaghello, Alessio Nencioni, Laura Sturla, Tiziana Vigliarolo, Giovanna Sociali, Laura Emionite, Federica Zamporlini

Source: Oncotarget
Oncotarget, vol. 7, no. 3, pp. 2968-2984

Subject Terms: Research Paper, NAMPT, CD73, NAD+, ovarian cancer, 5'-Nucleotidase/antagonists & inhibitors, 5'-Nucleotidase/genetics, Acrylamides/pharmacology, Adenosine Triphosphate/analogs & derivatives, Adenosine Triphosphate/pharmacology, Animals, Cell Line, Tumor, Cytokines/antagonists & inhibitors, Female, GPI-Linked Proteins/antagonists & inhibitors, GPI-Linked Proteins/genetics, Humans, Mice, Mice, Nude, NAD/metabolism, Niacinamide/analogs & derivatives, Niacinamide/biosynthesis, Nicotinamide Mononucleotide/metabolism, Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors, Ovarian Neoplasms/therapy, Piperidines/pharmacology, RNA Interference, RNA, Small Interfering/genetics, Oncology, Pharmacology, Nicotinamide phosphoribosyltransferase, chemistry.chemical_compound, chemistry, In vivo, Nicotinamide riboside, Internal medicine, medicine.medical_specialty, medicine, Enzyme, chemistry.chemical_classification, 5'-nucleotidase, Nicotinamide mononucleotide, NAD+ kinase, business.industry, business, Hematology, Biochemistry

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efff9d87d8a751a1e93561a5c11bfe4
http://europepmc.org/articles/PMC4823084

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