Search Results - "Neoplasms immunology"

1

Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs

Authors: Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E Lacy, Sophia N Karagiannis

Source: Harris, R J, Willsmore, Z, Laddach, R, Crescioli, S, Chauhan, J, Cheung, A, Black, A, Geh, J L C, MacKenzie Ross, A D, Healy, C, Tsoka, S, Spicer, J, Lacy, K E & Karagiannis, S N 2022, ' Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs ', OncoImmunology, vol. 11, no. 1, 2104426, pp. 2104426 . https://doi.org/10.1080/2162402X.2022.2104426

Subject Terms: Oncology, Immunology, Immunology and Allergy, B-Lymphocytes, Regulatory/immunology, Forkhead Transcription Factors/metabolism, Humans, Melanoma/immunology, Skin Neoplasms/immunology, T-Lymphocytes, Regulatory/immunology, Transforming Growth Factor beta/genetics, Tumor Microenvironment, Tumor Necrosis Factor-alpha/metabolism

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https://doi.org/10.1080/2162402x.2022.2104426

2

Interpretation of T cell states from single-cell transcriptomics data using reference atlases

Authors: Andreatta, Massimo, Corria-Osorio, Jesus, Müller, Sören, Cubas, Rafael, Coukos, George, Carmona, Santiago J.

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature communications, vol. 12, no. 1, pp. 2965

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https://doaj.org/article/9f2f292884da42c48b6390b29c262e36

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3

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Contributors: Cellular and Molecular Immunology, Faculty of Sciences and Bioengineering Sciences, Laboratory of Molecullar and Cellular Therapy, Department of Bio-engineering Sciences, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, Faculty of Medicine and Pharmacy, Basic (bio-) Medical Sciences, Cell Differentiation, Clinical sciences, Medical Oncology, Laboratory of Molecular and Medical Oncology

Source: Nature Neuroscience. 24:595-610

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https://doi.org/10.1038/s41593-020-00789-y

4

Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth

Authors: Eva Reijmen, Sven De Mey, Helena Van Damme, Kirsten De Ridder, Thierry Gevaert, Emmy De Blay, Luc Bouwens, Christine Collen, Lore Decoster, Marijke De Couck, Damya Laoui, Jacques De Grève, Mark De Ridder, Yori Gidron, Cleo Goyvaerts

Contributors: Laboratory of Molecullar and Cellular Therapy, Basic (bio-) Medical Sciences, Faculty of Medicine and Pharmacy, Clinical sciences, Cellular and Molecular Immunology, Faculty of Sciences and Bioengineering Sciences, Department of Bio-engineering Sciences, Radiation Therapy, Cell Differentiation, Medical Oncology, Laboratory of Molecular and Medical Oncology, Pain in Motion, Physiotherapy, Human Physiology and Anatomy, Public Health Sciences, Mental Health and Wellbeing research group, Medical Genetics, Translational Radiation Oncology and Physics

Source: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

Subject Terms: Aged, Animals, Carcinoma, Lewis Lung/immunology, Carcinoma, Non-Small-Cell Lung/immunology, Combined Modality Therapy, Female, Humans, Lung Neoplasms/immunology, Lymphocytes, Tumor-Infiltrating/immunology, Male, Mice, Inbred C57BL, Middle Aged, Tumor Burden, vagus nerve stimulation, neuromodulation, transcutaneous vagal nerve stimulation, radiotherapy, immunosuppressive tumor microenvironment (TME), lung cancer, tumor infiltrating lymphocytes, Immunologic diseases. Allergy, RC581-607, Immunology, Immunology and Allergy, Lung cancer, medicine.disease, medicine, Lung, medicine.anatomical_structure, Immunotherapy, medicine.medical_treatment, CD137, Cancer research, Radiation therapy, Therapeutic effect, Immune system, CD8, business.industry, business, Original Research

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https://hdl.handle.net/20.500.14017/db03c584-4d1b-4db1-b89a-f3a3e75849cf

5

Fingolimod and tumor-infiltrating lymphocytes in checkpoint-inhibitor treated cancer patients

Authors: Lukas Flatz, Eva Markert, Oltin T Pop, Thomas Hundsberger, Christoph Jakob Ackermann, Alexandre Moulin, Omar Ali, Stefan Diem, Joachim Müller, Fiamma Berner, Stefanie Müller, Sandra S. Ring

Contributors: University of Zurich, Flatz, Lukas

Source: Cancer immunology, immunotherapy, vol. 70, no. 2, pp. 563-568
Cancer Immunology, Immunotherapy

Subject Terms: Cancer Research, Oncology, Immunology, Immunology and Allergy, Lymphocyte, medicine.anatomical_structure, medicine, Pembrolizumab, Melanoma, medicine.disease, Fingolimod, medicine.drug, Immune system, Cancer research, Tumor-infiltrating lymphocytes, Cancer, Multiple sclerosis, business.industry, business, chemical and pharmacologic phenomena, 610 Medicine & health, 10177 Dermatology Clinic, 2723 Immunology and Allergy, 2403 Immunology, 2730 Oncology, 1306 Cancer Research, Female, Fingolimod Hydrochloride/pharmacology, Fingolimod Hydrochloride/therapeutic use, Humans, Immune Checkpoint Inhibitors/pharmacology, Immune Checkpoint Inhibitors/therapeutic use, Immunosuppressive Agents/pharmacology, Immunosuppressive Agents/therapeutic use, Lymphocytes/immunology, Lymphocytes, Tumor-Infiltrating/immunology, Middle Aged, Neoplasms/drug therapy, Neoplasms/immunology, Immune checkpoint inhibitors, Tumor immunology, Research Report

File Description: Hasan_Ali_CII.pdf - application/pdf; application/pdf

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https://doi.org/10.1007/s00262-020-02693-7

6

Impacto da resposta imunológica no prognóstico do paciente com carcinoma diferenciado de tiroide

Authors: Cunha, Lucas Leite, 1987

Contributors: Ward, Laura Sterian, 1956, Vassallo, José, 1957, Chiamolera, Maria Izabel, Cerutti, Janete Maria, Assumpção, Ligia Vera Montali da, Magna, Luis Alberto, Universidade Estadual de Campinas. Faculdade de Ciências Médicas, Programa de Pós-Graduação em Clínica Médica, UNIVERSIDADE ESTADUAL DE CAMPINAS

Source: Biblioteca Digital de Teses e Dissertações da Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP

Subject Terms: Neoplasias da glândula tireóide, Neoplasias - Imunologia, Prognóstico, Linfocitos B, Estadiamento de neoplasias, Thyroid Neoplasms, Neoplasms, Immunology, Prognosis, B-Lymphocytes, Neoplasm staging

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https://doi.org/10.47749/t/unicamp.2015.945251

7

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Source: Maller, O, Drain, A P, Barrett, A S, Borgquist, S, Ruffell, B, Zakharevich, I, Pham, T T, Gruosso, T, Kuasne, H, Lakins, J N, Acerbi, I, Barnes, J M, Nemkov, T, Chauhan, A, Gruenberg, J, Nasir, A, Bjarnadottir, O, Werb, Z, Kabos, P, Chen, Y-Y, Hwang, E S, Park, M, Coussens, L M, Nelson, A C, Hansen, K C & Weaver, V M 2021, ' Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression ', Nature Materials, vol. 20, no. 4, pp. 548-559 . https://doi.org/10.1038/s41563-020-00849-5
Nature materials, vol 20, iss 4
Nature materials

Subject Terms: Adult, Biopsy, Breast Neoplasms/immunology, Cell Line, Tumor, Collagen/metabolism, Female, Humans, Middle Aged, Protein-Lysine 6-Oxidase/metabolism, Stromal Cells/metabolism, Tumor-Associated Macrophages/metabolism, macromolecular substances, technology, industry, and agriculture, cardiovascular system, Mechanical Engineering, Mechanics of Materials, Condensed Matter Physics, General Materials Science, General Chemistry, Lysyl hydroxylase, biology.protein, biology, Metastasis, medicine.disease, medicine, Cancer research, Cancer, Lysyl oxidase, Stroma, Stromal cell, Hydroxylysine, chemistry.chemical_compound, chemistry, Immunohistochemistry, Cell Line, Tumor, Stromal Cells, Breast Neoplasms, Collagen, Protein-Lysine 6-Oxidase, Tumor-Associated Macrophages, Breast Cancer, 2.1 Biological and endogenous factors, Nanoscience & Nanotechnology, Article

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https://pure.au.dk/portal/da/publications/tumourassociated-macrophages-drive-stromal-celldependent-collagen-crosslinking-and-stiffening-to-promote-breast-cancer-aggression(52678664-4d14-494a-868c-fbcbe0843b24).html

8

A Systematic Review of Expression and Immunogenicity of Human Endogenous Retroviral Proteins in Cancer and Discussion of Therapeutic Approaches

Authors: Karen Nørgaard Nielsen, Mikkel Dons Müller, Peter Johannes Holst

Source: Müller, M D, Holst, P J & Nielsen, K N 2022, ' A systematic review of expression and immunogenicity of human endogenous retroviral proteins in cancer and discussion of therapeutic approaches ', International Journal of Molecular Sciences, vol. 23, no. 3, pp. 1330 . https://doi.org/10.3390/ijms23031330
International Journal of Molecular Sciences, Vol 23, Iss 1330, p 1330 (2022)

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https://doi.org/10.3390/ijms23031330

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9

CD29 identifies IFN-γ–producing human CD8 + T cells with an increased cytotoxic potential

Authors: Nicolet, Benoît P, Guislain, Aurélie, van Alphen, Floris P J, Gomez-Eerland, Raquel, Schumacher, Ton N M, van den Biggelaar, Maartje, Wolkers, Monika C, Afd Pharmaceutics, Pharmaceutics

Contributors: AII - Inflammatory diseases, Landsteiner Laboratory

Source: Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6686-6696. National Academy of Sciences
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6686. National Academy of Sciences

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https://doi.org/10.1073/pnas.1913940117

10

When Therapeutic IgA Antibodies Might Come of Age

Authors: Guy Gorochov, Delphine Sterlin

Contributors: Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), D.S. was supported for this work by an Institut Pasteur/Assistance Publique – Hôpitaux de Paris (APHP) interface fellowship. The Gorochov Laboratory is financed by Inserm, APHP (PHRC-20-0375), Sorbonne Université (SARS-CoV-2 Program), Région Île de France Domaines d’Intérêt Majeur (DIM Thérapie Génique), Fondation de France, and Agence Nationale de la Recherche (iCOVID ANR-20-COVI-0025)., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Immunologie et des Maladies Infectieuses (CIMI)

Source: Pharmacology
Pharmacology, Karger, 2021, 106 (1-2), pp.9-19. ⟨10.1159/000510251⟩
Pharmacology, 2021, 106 (1-2), pp.9-19. ⟨10.1159/000510251⟩

Subject Terms: Immunoglobulin A, Therapeutic antibody, Bioengineering, Primary antibody deficiency, MESH: Animals, MESH: Anti-Inflammatory Agents / therapeutic use, MESH: Host-Pathogen Interactions, MESH: Humans, MESH: Immunoglobulin A / adverse effects, MESH: Immunoglobulin A / therapeutic use, MESH: Immunotherapy* / adverse effects, MESH: Inflammation / drug therapy, MESH: Inflammation / immunology, MESH: Mice, MESH: Neoplasms / drug therapy, MESH: Neoplasms / immunology, MESH: Antibodies, Monoclonal / adverse effects, MESH: SARS-CoV-2 / immunology, MESH: Antibodies, Monoclonal / therapeutic use, MESH: Antineoplastic Agents, Immunological / therapeutic use, MESH: Antiviral Agents / adverse effects, MESH: Antiviral Agents / therapeutic use, MESH: COVID-19 / drug therapy, MESH: COVID-19 / immunology, MESH: COVID-19 / virology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Pharmacology, General Medicine, Immunotherapy, medicine.medical_treatment, medicine, Rotavirus, medicine.disease_cause, Virus, Poliovirus, Antibody, biology.protein, biology, Gut flora, biology.organism_classification, Immune system, Immunology, business.industry, business

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https://hal.sorbonne-universite.fr/hal-03139698

11

Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany

Authors: Helmut Kehrer, Erika Richtig, Peter Koelblinger, Lukas Koch, Matthias Karasek, Christine Hafner, Julia Maria Ressler, Joanna Mangana, Christian Posch, Veronica Aedo-Lopez, Julian Kofler, Olivier Michielin, Christoph Hoeller, Felix Weihsengruber, Sofiya Latifyan, Rita Silmbrod

Contributors: University of Zurich, Ressler, Julia Maria

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 9, no. 2, pp. e001701

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cancer Research, Pharmacology, Oncology, Molecular Medicine, Immunology, Immunology and Allergy, Internal medicine, medicine.medical_specialty, medicine, Treatment period, Melanoma, medicine.disease, Adverse effect, Talimogene laherparepvec, business.industry, business, Stage (cooking), Cohort, Progressive disease, Metastatic lesions, Oncolytic and Local Immunotherapy, oncolytic viruses, immunotherapy, melanoma, oncolytic virotherapy, Adult, Aged, Aged, 80 and over, Biological Products/adverse effects, Biological Products/therapeutic use, Disease Progression, Europe, Female, Herpesvirus 1, Human/immunology, Herpesvirus 1, Human/pathogenicity, Humans, Male, Melanoma/immunology, Melanoma/pathology, Melanoma/therapy, Middle Aged, Neoplasm Staging, Oncolytic Viruses/immunology, Oncolytic Viruses/pathogenicity, Retrospective Studies, Skin Neoplasms/immunology, Skin Neoplasms/pathology, Skin Neoplasms/therapy, Skin Neoplasms/virology, Time Factors, Treatment Outcome, 610 Medicine & health, 10177 Dermatology Clinic, 2723 Immunology and Allergy, 2403 Immunology, 1313 Molecular Medicine, 2730 Oncology, 3004 Pharmacology, 1306 Cancer Research

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https://jitc.bmj.com/content/9/2/e001701.full

12

CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens

Authors: Elise Ramia, Brian Stevenson, Greta Forlani, Michal Bassani-Sternberg, Michael Linnebacher, Elodie Lauret Marie Joseph, Roberto S. Accolla, HuiSong Pak, Justine Michaux, Florian Huber

Source: Molecular & Cellular Proteomics : MCP
Molecular & cellular proteomics, vol. 20, pp. 100032

Subject Terms: Research, Special Issue: Immunopeptidomics, Class II major histocompatibility complex transactivator, Immunopeptidomics, Antigen discovery, Glioblastoma, a.u., arbitrary units, APCs, antigen presenting cells, CIITA, class II major histocompatibility complex transactivator, CTL, cytotoxic T cells, ER, endoplasmic reticulum, ERAAP, ER aminopeptidase-associated with antigen processing, FDR, false discovery rate, GBM, glioblastoma, HCD, higher-energy collision dissociation, HLA, human leukocyte antigen, HLA-I, human leukocyte antigen class I, HLA-II, human leukocyte antigen class II, IFNγ, Interferon gamma, LFQ, label-free quantification, MHC, major histocompatibility complex, PBMCs, peripheral blood mononuclear cells, PSM, peptide spectrum match, SNPs, single nucleotide polymorphisms, SNVs, single nucleotide variants, TAAs, tumor-associated antigens, TAP, transporter-associated with antigen processing, TcR, T cell receptors, TH, T helper cells, WES, whole-exome sequencing, Molecular Biology, Biochemistry, Analytical Chemistry, Cancer research, Epitope, Biology, Antigen-presenting cell, Antigen, Human leukocyte antigen, CIITA, Major histocompatibility complex, biology.protein, T-cell receptor, T cell, medicine.anatomical_structure, medicine, Animals, Antigens, Neoplasm/immunology, Brain Neoplasms/immunology, Cattle, Cell Line, Tumor, Glioblastoma/immunology, Histocompatibility Antigens Class II/immunology, Humans, Nuclear Proteins/genetics, Nuclear Proteins/immunology, Peptides/immunology, Trans-Activators/genetics, Trans-Activators/immunology

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http://europepmc.org/articles/PMC8724627

13

Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome

Authors: Wouter Hendrickx, Peter J. K. Kuppen, Marianne Hokland, Jessica Roelands, Morten Andersen, Rob A. E. M. Tollenaar, Daniëlle Krijgsman, Davide Bedognetti, Cornelia H.L.A. Wieringa

Source: Molecular Immunology, 128, 205-218. PERGAMON-ELSEVIER SCIENCE LTD
Krijgsman, D, Roelands, J, Andersen, M N, Wieringa, C H L A, Tollenaar, R A E M, Hendrickx, W, Bedognetti, D, Hokland, M & Kuppen, P J K 2020, ' Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK-and NKT cells, and clinical outcome ', Molecular Immunology, vol. 128, pp. 205-218 . https://doi.org/10.1016/j.molimm.2020.10.012

Subject Terms: Colorectal cancer, NK cells, NKT cells, NK cell receptors, NK cell receptor ligands, Killer Cells, Natural/immunology, Humans, Middle Aged, Histocompatibility Antigens Class I/immunology, Intracellular Signaling Peptides and Proteins/immunology, Natural Killer T-Cells/immunology, Male, Colorectal Neoplasms/immunology, Disease-Free Survival, Phenotype, Receptors, Natural Killer Cell/immunology, Proliferating Cell Nuclear Antigen/immunology, Galectin 3/immunology, Aged, 80 and over, Adult, Female, Ligands, Aged, Molecular Biology, Immunology, CD1D, biology.protein, biology, Receptor, Cell, medicine.anatomical_structure, medicine, Flow cytometry, medicine.diagnostic_test, Human leukocyte antigen, Natural killer T cell, Receptor expression, Cancer research, Primary tumor, medicine.disease

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http://hdl.handle.net/1887/3185313

14

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

Authors: Alfonso Barreto, Paola Lasso, Amaia Martinez-Usatorre, Susana Fiorentino, Alejandra Gomez-Cadena, Alena Donda, Pedro Romero, Claudia Urueña

Source: Frontiers in Immunology, Vol 11 (2020)
Frontiers in immunology, vol. 11, pp. 584959
Frontiers in Immunology

Subject Terms: Immunology, Immunology and Allergy, CD8, Cytotoxic T cell, Immune system, PD-L1, biology.protein, biology, Antibody, T cell, medicine.anatomical_structure, medicine, business.industry, business, Melanoma, medicine.disease, Immunotherapy, medicine.medical_treatment, Cancer research, breast cancer, combined therapy, immunotherapy, natural products, melanoma, P2Et extract, lcsh:Immunologic diseases. Allergy, lcsh:RC581-607, Animals, Antibodies, Monoclonal/immunology, Antineoplastic Agents/immunology, B7-H1 Antigen/immunology, Breast Neoplasms/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Caesalpinia/immunology, Cell Line, Tumor, Cell Proliferation/physiology, Female, Humans, Hydrolyzable Tannins/immunology, Immunity/immunology, Immunologic Factors/immunology, MCF-7 Cells, Melanoma, Experimental/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Plant Extracts/immunology, Polyphenols/immunology, pd-l1, immune-response, cancer, antitumor, cells, expression, blockade, pathway, breast, immunoresistance, Original Research

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https://doi.org/10.3389/fimmu.2020.584959

15

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

Contributors: Oral Biochemistry, TechMed Centre, Biomaterials Science and Technology, Molecular cell biology and Immunology, Surgery, AII - Cancer immunology, CCA - Cancer biology and immunology, Amsterdam Gastroenterology Endocrinology Metabolism, Internal medicine, Medical oncology, Medical oncology laboratory

Source: Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27528-27539. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27528-27539. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27528. National Academy of Sciences
Affandi, A J, Grabowska, J, Olesek, K, Venegas, M L, Barbaria, A, Rodríguez, E, Mulder, P P G, Pijffers, H J, Ambrosini, M, Kalay, H, O’Toole, T, Zwart, E S, Kazemier, G, Nazmi, K, Bikker, F J, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Storm, G, van Kooyk, Y & den Haan, J M M 2020, ' Selective tumor antigen vaccine delivery to human CD169 + antigen-presenting cells using ganglioside-liposomes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 44, pp. 27528-27539 . https://doi.org/10.1073/pnas.2006186117
Affandi, A J, Grabowska, J, Olesek, K, Lopez Venegas, M, Barbaria, A, Rodríguez, E, Mulder, P P G, Pijffers, H J, Ambrosini, M, Kalay, H, O'Toole, T, Zwart, E S, Kazemier, G, Nazmi, K, Bikker, F J, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Storm, G, van Kooyk, Y & den Haan, J M M 2020, ' Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 44, pp. 27528-27539 . https://doi.org/10.1073/pnas.2006186117
Proceedings of the National Academy of Sciences of the United States of America

Subject Terms: SDG 3 - Good Health and Well-being, CD169, CD8 T cells, Dendritic cells, Siglec-1, Vaccination, CD8+ T cells, Gangliosides, Humans, Immunogenicity, Vaccine, Leukocytes, Mononuclear, Liposomes, Macrophages/immunology, Neoplasms/immunology, Primary Cell Culture, Proto-Oncogene Proteins/metabolism, Receptor Protein-Tyrosine Kinases/metabolism, Sialic Acid Binding Ig-like Lectin 1/metabolism, THP-1 Cells, Vaccination/methods, Vaccines, Subunit/administration & dosage, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Biological Sciences, Immunology and Inflammation, Immunogenicity, Vaccine, Leukocytes, Mononuclear, Vaccines, Subunit/administration & dosage, Multidisciplinary, Antigen-presenting cell, Chemistry, CD14, Antigen, Priming (immunology), Cytotoxic T cell, T cell, medicine.anatomical_structure, medicine, Tumor antigen, Cancer research, Tumor antigen vaccine

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https://research.vu.nl/en/publications/cd09ac07-dd23-4fd5-bd76-87f3083ea0b3

16

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Authors: Demmers, Laura C., Kretzschmar, Kai, Van Hoeck, Arne, Bar-Epraïm, Yotam E., van den Toorn, Henk W.P., Koomen, Mandy, van Son, Gijs, van Gorp, Joost, Pronk, Apollo, Smakman, Niels, Cuppen, Edwin, Clevers, Hans, Heck, Albert J.R., Wu, Wei, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics

Contributors: Hubrecht Institute for Developmental Biology and Stem Cell Research

Source: Nature Communications, 11(1). Nature Publishing Group
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Subject Terms: Antigen Presentation, Cell Line, Tumor, Clone Cells/immunology, Colorectal Neoplasms/immunology, HLA Antigens/metabolism, Humans, Ligands, Models, Biological, Neoplasm Proteins/metabolism, Organoids/immunology, Proteome/metabolism, Signal Transduction, Single-Cell Analysis, TOR Serine-Threonine Kinases/metabolism, Article, Immunotherapy, Tumour heterogeneity, Chemistry(all), Biochemistry, Genetics and Molecular Biology(all), Physics and Astronomy(all), Science, Cell Line, Tumor, Models, Biological, lcsh:Science, lcsh:Q, Biochemistry, Genetics and Molecular Biology(all), General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Human leukocyte antigen, Gene silencing, Proteomics, Antigen presentation, Organoid, Single-cell analysis, Cancer research, Biology, Cell, medicine.anatomical_structure, medicine, medicine.medical_treatment

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https://pure.knaw.nl/portal/en/publications/c57bd421-e6fc-43d5-bc63-b3609b3e099f

17

Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus

Authors: Curigliano, G., Banerjee, S., Cervantes, A., Garassino, M.C., Garrido, P., Girard, N., Haanen, J., Jordan, K., Lordick, F., Machiels, J.P., Michielin, O., Peters, S., Tabernero, J., Douillard, J.Y., Pentheroudakis, G.

Contributors: Panel members, Addeo, A., Albiges, L., Ascierto, P.A., Banerjee, S., Barlesi, F., Caldas, C., Cardoso, F., Cervantes, A., Chaberny, I.F., Cherny, N.I., Choueiri, T.K., Chua, MLK, Criscitiello, C., Curigliano, G., de Azambuja, E., De Ruysscher, D., de Vries, E., Dent, R., Douillard, J.Y., D'Ugo, D., Dziadziuszko, R., Faivre-Finn, C., Felip, E., Garassino, M., Garrido, P., Girard, N., Glynne-Jones, R., Golfinopoulos, V., Haanen, J., Hamilton, E., Jänne, P.A., Jordan, K., Kanesvaran, R., Kim, S.B., Liebert, U.G., Lordick, F., Machiels, J.P., Michielin, O., Mok, TSK, Morgan, G., Obermannova, R., Park, K., Passaro, A., Pentheroudakis, G., Peters, S., Reck, M., Salazar Soler, R., Scotté, F., Senan, S., Sessa, C., Smyth, E., Soo, R., Soria, J.C., Spicer, J., Strasser, F., Tabernero, J., Tan, DSW, Trapani, D., Van Cutsem, E., van Halteren, H., van Schil, P.E., Veronesi, G., Yang, J.

Source: Annals of oncology, vol. 31, no. 10, pp. 1320-1335

Subject Terms: Betacoronavirus, Consensus, Coronavirus Infections/epidemiology, Coronavirus Infections/immunology, Coronavirus Infections/therapy, Disease Management, Europe/epidemiology, Granulocyte Colony-Stimulating Factor/pharmacology, Granulocyte Colony-Stimulating Factor/therapeutic use, Humans, Medical Oncology/methods, Medical Oncology/standards, Neoplasms/epidemiology, Neoplasms/immunology, Neoplasms/therapy, Pandemics/prevention & control, Pneumonia, Viral/epidemiology, Pneumonia, Viral/immunology, Pneumonia, Viral/therapy, Real-Time Polymerase Chain Reaction/methods, Real-Time Polymerase Chain Reaction/standards, Societies, Medical/standards, T-Lymphocytes, Cytotoxic/drug effects, T-Lymphocytes, Cytotoxic/immunology, Telemedicine/methods, Telemedicine/standards, education

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https://serval.unil.ch/resource/serval:BIB_957BAED3FD8F.P001/REF.pdf

18

Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

Contributors: Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), QIMR Berghofer Medical Research Institute, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université libre de Bruxelles (ULB), Centre de Physiopathologie Toulouse Purpan (CPTP), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC - CNS), Université Nice Sophia Antipolis (... - 2019) (UNS), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Source: Immunity, 53 (4
Immunity
Immunity, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩
Immunity, Elsevier, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩

File Description: 1 full-text file(s): application/pdf

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19

Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors

Authors: Lia Gonçalves Pinho, Emmanuel Donnadieu, Vinicius Cotta-de-Almeida, Loïc Dupré

Contributors: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This work was funded by Brazilian National Council for Scientific and Technological Development (CNPq), L.G.P. was supported by grant no. 140718/2019-2 and V.C.A. was supported by grant no. 310329/2019-1. The Coordination for the Improvement of Higher Education Personnel (CAPES), with support from the Program PrInt-Fiocruz-CAPES, the Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), and Mercosur Fund for Structural Convergence (FOCEM, 03/11) provided funding for L.G.P. and V.C.A. E.D. was supported by a funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 667980., European Project: 667980,H2020,H2020-PHC-2015-two-stage,CARAT(2016)

Source: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2020, 108 (4), pp.1067-1079. ⟨10.1002/JLB.1MR0520-746R⟩

Subject Terms: T cell trafficking, cancer immunotherapy, chimeric antigen receptor engineering, extracellular matrix, motility, tumor microenvironment, MESH: Antigens, Neoplasm / immunology, MESH: Cell Movement / immunology, MESH: T-Lymphocytes* / immunology, MESH: T-Lymphocytes* / pathology, MESH: Tumor Microenvironment / immunology, MESH: Humans, MESH: Immunotherapy, Adoptive, MESH: Neoplasms* / immunology, MESH: Neoplasms* / pathology, MESH: Neoplasms* / therapy, MESH: Receptors, Chimeric Antigen / immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Review, XLIV Congress of the Brazilian Society of Immunology, Guest Editors: João P.B. Viola, Lis Antonelli, Martin Bonamino, Jose Alves Filho, and Helder Nakaya, Reviews, Cell Biology, Immunology, Immunology and Allergy, Cancer research, Biology, Immune checkpoint, Tumor microenvironment, T cell, medicine.anatomical_structure, medicine, Cancer cell, Chimeric antigen receptor, Cytotoxic T cell, Antibody, biology.protein, Cancer immunotherapy, medicine.medical_treatment

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https://ut3-toulouseinp.hal.science/hal-03536616

20

Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell–Mediated Tumor Regression in the MB49 Bladder Cancer Model

Authors: Lenka Polak, Stefano La Rosa, Denise Nardelli-Haefliger, Mathieu F. Chevalier, Patrice Jichlinski, Jacques-Antoine Haefliger, Paul Martel, Rim Hojeij, Sonia Domingos-Pereira, Laurent Derré, Karthik Sathiyanadan

Source: Cancer immunology research, vol. 7, no. 4, pp. 621-629

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