Search Results - "Neoplasm Proteins genetics"

1

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Authors: Dale R. Nyholt, Sally Mortlock, Amanda B. Spurdle, Tracy A. O'Mara, Pik Fang Kho, Peter Rogers, Grant W. Montgomery, Dylan M. Glubb

Source: Kho, P F, Mortlock, S, Endometrial Cancer Association Consortium, International Endometriosis Genetics Consortium, Rogers, P A W, Nyholt, D R, Montgomery, G W, Spurdle, A B, Glubb, D M, O'Mara, T A & Nyegaard, M 2021, ' Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus ', Human Genetics, vol. 140, no. 9, pp. 1353-1365 . https://doi.org/10.1007/s00439-021-02312-0

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb10093d8decc801de38e8be8228849e
https://link.springer.com/content/pdf/10.1007/s00439-021-02312-0.pdf

2

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

Contributors: Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), The University of Sydney, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut Curie, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry [University of Toronto], University of Toronto, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Mécanismes de tumorigenèse et thérapies ciblées, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, This work was supported by the National Center for Scientific Research (CNRS) to EB, the National Institute of Health and Medical Research (INSERM), the University of Lyon1, La Ligue Nationale (Drôme), Inserm-Transfert (EB). GV was supported by the Labex DEVweCAN, MG, MB by the French National Cancer Institute (INCa), CK by the Marie-Curie-Individual-Fellowship (655777-miR-OMeS). CAP, LC, and MM by CANCER-ID (FP7/2007-2013) and EFPIA., The authors thank Anne Flourens, Cyprien Tilmant, Tina Louadj, and both CeCIL and ALECS platforms (Faculté de Médecine Laennec, Lyon) for their assistance., Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS], Institut de Génomique Fonctionnelle de Lyon [IGFL], Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB], Centre de recherche en neurosciences de Lyon [CRNL], Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 [AIDMP], Institut Curie [Paris], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Institut de biologie de Lille - IBL [IBLI], Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), IGFL - Institut de Génomique Fonctionnelle de Lyon, Centre Hospitalier de l'Université de Montréal (CHUM), Equipe Impact, Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, Centre de Biologie Et de Pathologie Est - Bron Centre médical, Marie Curie Research Institute, MRCI, Genetique Moleculaire des Cancers d'Origine Epitheliale, Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Surgery, Breast Health Center, Medical University Vienna, Institut du Cancer de Montpellier (ICM), Department of Molecular and Medical Genetics, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie Générale et Médicale, INSERM-CNRS U.189 Faculté de Médecine Lyon-Sud, Centre de Recherche en Géomatique [Laval] (CRG), Université Laval, Swiss Federal Office for the Environment FOEN, Département de Génétique [Institut Curie, Paris] (Unité de Pharmacogénomique), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie et chimie des protéines [Lyon] (IBCP), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Source: Oncogene
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3 ⟩
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩

Subject Terms: MESH: Animals, MESH: Bone Neoplasms/genetics, MESH: Breast Neoplasms/metabolism, MESH: Breast Neoplasms/pathology, MESH: Humans, MESH: Female, MESH: Gene Expression Regulation, Neoplastic, MESH: Mammary Neoplasms, Animal/genetics, MESH: Mammary Neoplasms, Animal/metabolism, MESH: Mammary Neoplasms, Animal/pathology, MESH: Mice, MESH: Mice, Inbred BALB C, MESH: Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Neoplasm Proteins/genetics, MESH: Neoplasm Proteins/metabolism, MESH: Receptor Activator of Nuclear Factor-kappa B/genetics, MESH: Bone Neoplasms/metabolism, MESH: Receptors, Estrogen/genetics, MESH: Receptors, Estrogen/metabolism, MESH: Bone Neoplasms/pathology, MESH: Breast Neoplasms/genetics, MESH: Bone Neoplasms/secondary, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Animals, Bone Neoplasms/genetics, Breast Neoplasms/metabolism, Breast Neoplasms/pathology, Humans, Female, Gene Expression Regulation, Neoplastic, Mammary Neoplasms, Animal/genetics, Mammary Neoplasms, Animal/metabolism, Mammary Neoplasms, Animal/pathology, Mice, Mice, Inbred BALB C, Receptor Activator of Nuclear Factor-kappa B/biosynthesis, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Receptor Activator of Nuclear Factor-kappa B/genetics, Bone Neoplasms/metabolism, Receptors, Estrogen/genetics, Receptors, Estrogen/metabolism, Bone Neoplasms/pathology, Breast Neoplasms/genetics, Bone Neoplasms/secondary, [SDV]Life Sciences [q-bio], Cancer Research, Genetics, Molecular Biology, Cancer cell, Breast cancer, medicine.disease, medicine, Transcriptome, Primary tumor, Biology, Cancer research, PI3K/AKT/mTOR pathway, RANKL, biology.protein, Circulating tumor cell, Metastatic breast cancer

File Description: application/octet-stream; application/pdf

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673afe46894df907867170c048c800d7
https://hal.archives-ouvertes.fr/hal-02353108

3

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Authors: Tin, Adrienne, Marten, Jonathan, Halperin Kuhns, Victoria L, Li, Yong, Wuttke, Matthias, Kirsten, Holger, Sieber, Karsten B, Qiu, Chengxiang, Gorski, Mathias, Yu, Zhi, Giri, Ayush, Sveinbjornsson, Gardar, Li, Man, Chu, Audrey Y, Hoppmann, Anselm, O'Connor, Luke J, Prins, Bram, Nutile, Teresa, Noce, Damia, Akiyama, Masato, Cocca, Massimiliano, Ghasemi, Sahar, Van Der Most, Peter J, Horn, Katrin, Xu, Yizhe, Fuchsberger, Christian, Sedaghat, Sanaz, Afaq, Saima, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan JL, Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L, Biino, Ginevra, Boerwinkle, Eric, Bottinger, Erwin P, Boutin, Thibaud S, Brumat, Marco, Burkhardt, Ralph, Campana, Eric, Campbell, Archie, Campbell, Harry, Carroll, Robert J, Catamo, Eulalia, Chambers, John C, Ciullo, Marina, Concas, Maria Pina, Coresh, Josef, Corre, Tanguy, Cusi, Daniele, Felicita, Sala Cinzia, De Borst, Martin H, De Grandi, Alessandro, De Mutsert, Renée, De Vries, Aiko PJ, Delgado, Graciela, Demirkan, Ayşe, Devuyst, Olivier, Dittrich, Katalin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Evans, Michele K, Gansevoort, Ron T, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Gögele, Martin, Gordon, Scott D, Gudbjartsson, Daniel F, Gudnason, Vilmundur, German Chronic Kidney Disease Study, Haller, Toomas, Hamet, Pavel, Harris, Tamara B, Hayward, Caroline, Hicks, Andrew A, Hofer, Edith, Holm, Hilma, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Lewis, Raychel M, Ingelsson, Erik, Jakobsdottir, Johanna, Jonsdottir, Ingileif, Jonsson, Helgi, Joshi, Peter K, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Kerr, Shona M, Kiess, Wieland, Kleber, Marcus E, Koenig, Wolfgang, Kooner, Jaspal S, Körner, Antje, Kovacs, Peter, Krämer, Bernhard K, Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, La Bianca, Martina, Lange, Leslie A, Lehne, Benjamin, Lehtimäki, Terho, Lifelines Cohort Study, Liu, Jun, Loeffler, Markus, Loos, Ruth JF, Lyytikäinen, Leo-Pekka, Magi, Reedik, Mahajan, Anubha, Martin, Nicholas G, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, V. A. Million Veteran Program, O'Donnell, Christopher J, Wilson, Otis D, Gaziano, J Michael, Mishra, Pashupati P, Mohlke, Karen L, Mononen, Nina, Montgomery, Grant W, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Nadkarni, Girish N, Nalls, Mike A, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, Noordam, Raymond, O'Connell, Jeffrey R, Olafsson, Isleifur, Padmanabhan, Sandosh, Penninx, Brenda WJH, Perls, Thomas, Peters, Annette, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Polasek, Ozren, Ponte, Belen, Porteous, David J, Poulain, Tanja, Preuss, Michael H, Rabelink, Ton J, Raffield, Laura M, Raitakari, Olli T, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rizzi, Federica, Robino, Antonietta, Rudan, Igor, Krajcoviechova, Alena, Cifkova, Renata, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A, Saba, Yasaman, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Shaffer, Christian M, Smith, Albert V, Smith, Blair H, Spracklen, Cassandra N, Strauch, Konstantin, Stumvoll, Michael, Sulem, Patrick, Tajuddin, Salman M, Teren, Andrej, Thiery, Joachim, Thio, Chris HL, Thorsteinsdottir, Unnur, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, Vaccargiu, Simona, Van Der Harst, Pim, Van Duijn, Cornelia M, Verweij, Niek, Völker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Whitfield, John B, Wild, Sarah H, Wilson, James F, Yang, Qiong, Zhang, Weihua, Zonderman, Alan B, Bochud, Murielle, Wilson, James G, Pendergrass, Sarah A, Ho, Kevin, Parsa, Afshin, Pramstaller, Peter P, Psaty, Bruce M, Böger, Carsten A, Snieder, Harold, Butterworth, Adam, Okada, Yukinori, Edwards, Todd L, Stefansson, Kari, Susztak, Katalin, Scholz, Markus, Heid, Iris M, Hung, Adriana M, Teumer, Alexander, Pattaro, Cristian, Woodward, Owen M, Vitart, Veronique, Köttgen, Anna

Contributors: Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Life Course Epidemiology (LCE), Internal medicine, APH - Mental Health, Psychiatry

Source: Tin, Adrienne; Marten, Jonathan; et al; Devuyst, Olivier (2019). Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51(10):1459-1474.
Nature genetics
Nature Genetics, 51(10), 1459-+. NATURE PUBLISHING GROUP
Nature Genetics, 51(10), 1459-1474. Nature Publishing Group
Tin, A, Marten, J, Halperin Kuhns, V L, Li, Y, Wuttke, M, Kirsten, H, Sieber, K B, Qiu, C, Gorski, M, Yu, Z, Giri, A, Sveinbjornsson, G, Li, M, Chu, A Y, Hoppmann, A, O’Connor, L J, Prins, B, Nutile, T, Noce, D, Akiyama, M, Cocca, M, Ghasemi, S, van der Most, P J, Horn, K, Xu, Y, Fuchsberger, C, Sedaghat, S, Afaq, S, Amin, N, Ärnlöv, J, Bakker, S J L, Bansal, N, Baptista, D, Bergmann, S, Biggs, M L, Biino, G, Boerwinkle, E, Bottinger, E P, Boutin, T S, Brumat, M, Burkhardt, R, Campana, E, Campbell, A, Campbell, H, Carroll, R J, Catamo, E, Chambers, J C, Ciullo, M, Concas, M P, Coresh, J, Corre, T, Cusi, D, Sala, C F, de Borst, M H, De Grandi, A, de Mutsert, R, de Vries, A P J, Delgado, G, Demirkan, A, Devuyst, O, Dittrich, K, Eckardt, K-U, Ehret, G, Endlich, K, Evans, M K, Gansevoort, R T, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Gögele, M, Gordon, S D, Gudbjartsson, D F, Gudnason, V, Haller, T, Hamet, P, Harris, T B, Hayward, C, Hicks, A A, Hofer, E, Holm, H, Huang, W, Hutri-Kähönen, N, Hwang, S-J, Arfan Ikram, M, Lewis, R M, Ingelsson, E, Jakobsdottir, J, Jonsdottir, I, Jonsson, H, Joshi, P K, Josyula, N S, Jung, B, Kähönen, M, Kamatani, Y, Kanai, M, Kerr, S M, Kiess, W, Kleber, M E, Koenig, W, Kooner, J S, Körner, A, Kovacs, P, Krämer, B K, Kronenberg, F, Kubo, M, Kühnel, B, La Bianca, M, Lange, L A, Lehne, B, Lehtimäki, T, Liu, J, Loeffler, M, Loos, R J F, Lyytikäinen, L-P, Mägi, R, Mahajan, A, Martin, N G, März, W, Mascalzoni, D, Matsuda, K, Meisinger, C, Meitinger, T, Metspalu, A, Milaneschi, Y, O'Donnell, C J, Wilson, O D, Gaziano, J M, Mishra, P P, Mohlke, K L, Mononen, N, Montgomery, G W, Mook-Kanamori, D O, Müller-Nurasyid, M, Nadkarni, G N, Nalls, M A, Nauck, M, Nikus, K, Ning, B, Nolte, I M, Noordam, R, O'Connell, J R, Olafsson, I, Padmanabhan, S, Penninx, B W J H, Perls, T, Peters, A, Pirastu, M, Pirastu, N, Pistis, G, Polasek, O, Ponte, B, Porteous, D J, Poulain, T, Preuss, M H, Rabelink, T J, Raffield, L M, Raitakari, O T, Rettig, R, Rheinberger, M, Rice, K M, Rizzi, F, Robino, A, Rudan, I, Krajcoviechova, A, Cifkova, R, Rueedi, R, Ruggiero, D, Ryan, K A, Saba, Y, Salvi, E, Schmidt, H, Schmidt, R, Shaffer, C M, Smith, A V, Smith, B H, Spracklen, C N, Strauch, K, Stumvoll, M, Sulem, P, Tajuddin, S M, Teren, A, Thiery, J, Thio, C H L, Thorsteinsdottir, U, Toniolo, D, Tönjes, A, Tremblay, J, Uitterlinden, A G, Vaccargiu, S, van der Harst, P, van Duijn, C M, Verweij, N, Völker, U, Vollenweider, P, Waeber, G, Waldenberger, M, Whitfield, J B, Wild, S H, Wilson, J F, Yang, Q, Zhang, W, Zonderman, A B, Bochud, M, Wilson, J G, Pendergrass, S A, Ho, K, Parsa, A, Pramstaller, P P, Psaty, B M, Böger, C A, Snieder, H, Butterworth, A S, Okada, Y, Edwards, T L, Stefansson, K, Susztak, K, Scholz, M, Heid, I M, Hung, A M, Teumer, A & Pattaro, C & Woodward, O M & Vitart, V & Köttgen, A 2019, ' Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels ', Nature Genetics, vol. 51, no. 10, pp. 1459–1474 . https://doi.org/10.1038/s41588-019-0504-x
Nature Genetics, Vol. 51, No 10 (2019) pp. 1459-1474

Subject Terms: Institute of Physiology, 570 Life sciences, biology, 610 Medicine & health, Genetics, Article, Pleiotropy, Genome-wide association study, Gout, medicine.disease, medicine, Gene, Kidney metabolism, HNF1A, Biology, Genetic marker, Locus (genetics), German Chronic Kidney Disease Study, Lifelines Cohort Study, V. A. Million Veteran Program, Liver, Kidney, Humans, Cardiovascular Diseases, Metabolic Diseases, Genetic Predisposition to Disease, Uric Acid, Neoplasm Proteins, Genetic Markers, Cohort Studies, Signal Transduction, Organ Specificity, Polymorphism, Single Nucleotide, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 4, Genome-Wide Association Study, Genetic Loci, ATP Binding Cassette Transporter, Subfamily G, Member 2, ddc:616, ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/genetics, Gout/blood, Gout/epidemiology, Gout/genetics, Hepatocyte Nuclear Factor 1-alpha/genetics, Hepatocyte Nuclear Factor 4/genetics, Kidney/metabolism, Kidney/pathology, Liver/metabolism, Liver/pathology, Metabolic Diseases/blood, Metabolic Diseases/epidemiology, Metabolic Diseases/genetics, Neoplasm Proteins/genetics, Uric Acid/blood

File Description: application/pdf; Print-Electronic

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ca1074ea810ae60d4dc8583413fe55
https://www.zora.uzh.ch/id/eprint/177068/1/s41588-019-0504-x.pdf

4

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Authors: Bennett, David A., Zhao, Wei, Lewis, Cathryn M., Schulze, Thomas G., De Jager, Philip L., Nöthen, Markus M., Demirkan, Ayse, Ladwig, Karl-Heinz, de Geus, Eco, Lahti, Jari, Rietschel, Marcella, Tiemeier, Henning, Uher, Rudolf, Martin, Nicholas G., Murabito, Joanne M., Amare, Azmeraw T., Esko, Tonu, Kloiber, Stefan, Rice, John P., Gill, Michael, Lucae, Susanne, Montgomery, Grant W., Kutalik, Zoltán, Penninx, Brenda W., Quiroz, Jorge A., Jan Hottenga, Jouke, Faul, Jessica D., Purcell, Shaun M., Hartman, Catharina A., van Duijn, Cornelia M., Weissman, Myrna M., Tanaka, Toshiko, Müller-Myhsok, Bertram, Fornage, Myriam, O'Donovan, Michael C., Pergadia, Michele L., Byrne, Enda M., Kardia, Sharon L.R., Direk, Nese, van Grootheest, Gerard, Domenici, Enrico, Horn, Carsten, Van der Auwera, Sandra, Smit, Johannes H., Sullivan, Patrick F., Boomsma, Dorret, Mosley, Thomas H., Li, Qingqin S., Lunetta, Kathryn L., Lewis, Glyn, Potash, James B., Buttenschøn, Henriette N., Hek, Karin, Breen, Gerome, Shi, Jianxin, Clarke, Toni-Kim, Eriksson, Johan G., Umbricht, Daniel, Preisig, Martin, Heath, Andrew C., Homuth, Georg, Ferrucci, Luigi, Rivera, Margarita, Nyholt, Dale R., Hamilton, Steven P., Koenen, Karestan, Dunn, Erin C., Baune, Bernhard T., Willemsen, Gonneke, Weir, David R., Levinson, Douglas F., Yang, Jingyun, Perlis, Roy, Cichon, Sven, Dannlowski, Udo, Räikkönen, Katri, Ripke, Stephan, Smoller, Jordan W., Mors, Ole, MacIntyre, Donald J., Llewellyn, David J., Tansey, Katherine E., McIntosh, Andrew M., Metspalu, Andres, Smith, Jennifer A., Cornelis, Marilyn C., Sinnamon, Grant C., Ware, Erin B., Teumer, Alexander, Shyn, Stanley, Air, Tracy, Blackwood, Douglas H.R., Castelao, Enrique, Grabe, Hans Jörgen, Madden, Pamela, Gordon, Scott D., Williams, Stephanie, Amin, Najaf, Hofman, Albert, Snieder, Harold, Børglum, Anders D., Milaneschi, Yuri

Contributors: Biological Psychology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, University of Helsinki, Clinicum, University of Helsinki, Medicum, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics

Source: Biological Psychiatry, 82(5), 322-329. Elsevier USA
BIOLOGICAL PSYCHIATRY
Biological Psychiatry, 82(5), 322-329. ELSEVIER SCIENCE INC
Biological psychiatry 82(5), 322-329 (2017). doi:10.1016/j.biopsych.2016.11.013
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T-K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, de Geus, E, Gill, M, Gordon, S D, Grabe, H J, van Grootheest, G, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Jan Hottenga, J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K-H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O'Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Van der Auwera, S, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2017, ' An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry, vol. 82, no. 5, pp. 322-329 . https://doi.org/10.1016/j.biopsych.2016.11.013
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T-K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, Geus, E D, Gill, M, Gordon, S D, Grabe, H J, Grootheest, G V, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Hottenga, J J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K-H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley Jr, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O’Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera Sanchez, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, der Auwera, S V, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2016, ' An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.11.013
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, Van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, Geus, E D, Gill, M, Gordon, S D, Grabe, H J, Grootheest, G V, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Hottenga, J J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, Macintyre, D J, Madden, P, Martin, N G, Mcintosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-myhsok, B, Nöthen, M M, Nyholt, D R, O’donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Der Auwera, S V, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2016, ' An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2016.11.013

Subject Terms: CHARGE consortium, Depressive symptoms, FHIT gene, Genome-wide association study, Major depressive disorder, Psychiatric Genomics Consortium, Biological Psychiatry, Acid Anhydride Hydrolases/genetics, Depression/genetics, Depressive Disorder/genetics, European Continental Ancestry Group/genetics, Genetic Loci, Genetic Predisposition to Disease, Humans, Neoplasm Proteins/genetics, Phenotype, Journal Article, NATIONAL COMORBIDITY SURVEY, MAJOR DEPRESSION, MINOR DEPRESSION, SUBTHRESHOLD DEPRESSION, SYMPTOMS, RISK, DISORDER, STRESS, HERITABILITY, POPULATION, 3112 Neurosciences, 3124 Neurology and psychiatry, 515 Psychology, Locus (genetics), medicine.disease, medicine, Genetics, Single-nucleotide polymorphism, Psychology, Linkage disequilibrium, Population, education.field_of_study, education, SNP, Genetic association, ddc:570, major depressive disorder, genome-wide association study, Article

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5

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression

Authors: Molnár, Eszter, Garay, Tamás, Donia, Marco, Baranyi, Marcell, Rittler, Dominika, Berger, Walter, Tímár, József, Grusch, Michael, Hegedűs, Balázs

Source: International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4484 (2019)
Molnár, E, Garay, T, Donia, M, Baranyi, M, Rittler, D, Berger, W, Tímár, J, Grusch, M & Hegedűs, B 2019, ' Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma : Increased Cell Migration and Its Association with EGFR Expression ', International Journal of Molecular Sciences, vol. 20, no. 18, 4484 . https://doi.org/10.3390/ijms20184484

Subject Terms: melanoma, V600E BRAF mutation, vemurafenib resistance, EGFR, PD-L1, migration, Article, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis, Microphthalmia-associated transcription factor, Vemurafenib, medicine.drug, medicine, Chemistry, Cancer research, Melanoma, medicine.disease, V600E, Cell migration, MAPK/ERK pathway, EGFR inhibitors, Epidermal growth factor receptor, biology.protein, biology, lcsh:Biology (General), lcsh:QH301-705.5, lcsh:Chemistry, lcsh:QD1-999, Adult, Aged, Cell Line, Tumor, Cell Movement/drug effects, Cell Proliferation/drug effects, Drug Resistance, Neoplasm/drug effects, Epithelial-Mesenchymal Transition/drug effects, ErbB Receptors/metabolism, Erlotinib Hydrochloride/pharmacology, Female, Gene Expression Regulation, Neoplastic/drug effects, Humans, Inhibitory Concentration 50, Male, Melanoma/drug therapy, Middle Aged, Mutation/genetics, Neoplasm Proteins/genetics, Phenotype, Proto-Oncogene Proteins B-raf/genetics, RNA, Messenger/genetics, Signal Transduction/drug effects, Time Factors, Vemurafenib/pharmacology, Journal Article, neoplasms, skin and connective tissue diseases, digestive system diseases

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6

Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status

Authors: Dueñas, Marta, Pérez-Figueroa, Andrés, Oliveira, Carla, Suárez-Cabrera, Cristian, Sousa, Abel, Oliveira, Patricia, Villacampa, Felipe, Paramio, Jesús M., Martínez-Fernández, Mónica

Contributors: Instituto de Investigação e Inovação em Saúde

Source: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Subject Terms: Article, Bladder cancer, Bladder, Multidisciplinary, E2F, Medicine, business.industry, business, Exon, Downregulation and upregulation, Cancer research, medicine.disease, Alternative splicing, Mdm2, biology.protein, biology, Gene expression, Tumor initiation, Ciencias de la Salud::Urología y nefrología [Materias Investigacion], lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q, Alternative Splicing, Carcinoma, Transitional Cell / genetics, Carcinoma, Transitional Cell / pathology, Disease-Free Survival, E2F Transcription Factors / genetics, Exons / genetics, Gene Expression Regulation, Neoplastic, Gene Ontology, Genes, myc, Genes, p53, Humans, Kaplan-Meier Estimate, Mutation, Missense, Neoplasm Invasiveness, Neoplasm Proteins / biosynthesis, Neoplasm Proteins / genetics, Papilloma / genetics, Papilloma / pathology, Prognosis, Proto-Oncogene Proteins c-mdm2 / genetics, Proto-Oncogene Proteins c-myc / genetics, Recurrence, Tissue Array Analysis, Urinary Bladder Neoplasms / genetics, Urinary Bladder Neoplasms / pathology, Whole Exome Sequencing

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http://europepmc.org/articles/PMC6637137

7

AON-Mediated Exon Skipping to Bypass Protein Truncation in Retinal Dystrophies Due to the Recurrent CEP290 c.4723A > T Mutation. Fact or Fiction?

Authors: Barny, Iris, Perrault, Isabelle, Michel, Christel, Goudin, Nicolas, Defoort-Dhellemmes, Sabine, Ghazi, Imad, Kaplan, Josseline, Rozet, Jean-Michel, Gerard, Xavier

Source: Genes
Genes, vol. 10, no. 5
Genes, Vol 10, Iss 5, p 368 (2019)

Subject Terms: Genetics(clinical), Genetics, RNA splicing, Biology, Molecular biology, Ciliopathy, medicine.disease, medicine, Exon, Exon skipping, Cilium, Mutation, medicine.disease_cause, Retinal, chemistry.chemical_compound, chemistry, Retinal Dystrophies, Article, Leber congenital amaurosis and allied retinal ciliopathies, CEP290, Flanders founder c.4723A > T nonsense mutation, Cilia elongation, spontaneous nonsense correction, AON-mediated exon skipping, Antigens, Neoplasm/genetics, Antigens, Neoplasm/metabolism, Cell Cycle Proteins/genetics, Cell Cycle Proteins/metabolism, Codon, Nonsense, Cytoskeletal Proteins/genetics, Cytoskeletal Proteins/metabolism, Exons/genetics, Eye Abnormalities/genetics, Eye Diseases, Hereditary/genetics, Humans, Male, Neoplasm Proteins/genetics, Oligonucleotides, Antisense/genetics, RNA Splicing, Retina/metabolism, Retinal Dystrophies/genetics, Retinal Dystrophies/physiopathology, Flanders founder c.4723A > Leber congenital amaurosis and allied retinal ciliopathies, T nonsense mutation, Flanders founder c.4723A >, lcsh:Genetics, lcsh:QH426-470

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8

A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population

Authors: Faundes, Víctor, Malone, Geraldine, Newman, William G., Banka, Siddharth

Source: Faundes, V, Malone, G, Newman, W G & Banka, S 2019, ' A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population ', Journal of Human Genetics, vol. 64, no. 2, pp. 161-170 . https://doi.org/10.1038/s10038-018-0536-6

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9

Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis

Authors: Fadista, João, Skotte, Line, Geller, Frank, Bybjerg-Grauholm, Jonas, Gørtz, Sanne, Romitti, Paul A, Caggana, Michele, Kay, Denise M, Matsson, Hans, Boyd, Heather A, Hougaard, David M, Nordenskjöld, Agneta, Mills, James L, Melbye, Mads, Feenstra, Bjarke

Source: Fadista, J, Skotte, L, Geller, F, Bybjerg-Grauholm, J, Gørtz, S, Romitti, P A, Caggana, M, Kay, D M, Matsson, H, Boyd, H A, Hougaard, D M, Nordenskjöld, A, Mills, J L, Melbye, M & Feenstra, B 2019, ' Genome-wide meta-analysis identifies BARX 1 and EML 4-MTA 3 as new loci associated with infantile hypertrophic pyloric stenosis ', Human Molecular Genetics, vol. 28, no. 2, pp. 332-340 . https://doi.org/10.1093/hmg/ddy347

Subject Terms: Case-Control Studies, Cell Cycle Proteins/genetics, Cohort Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Homeodomain Proteins/genetics, Humans, Infant, Infant, Newborn, Microtubule-Associated Proteins/genetics, Neoplasm Proteins/genetics, Polymorphism, Single Nucleotide, Pyloric Stenosis, Hypertrophic/genetics, Serine Endopeptidases/genetics, Transcription Factors/genetics, Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

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10

Revisiting CLEC12A as leukaemic stem cell marker in AML:highlighting the necessity of precision diagnostics in patients eligible for targeted therapy

Authors: Bill, Marie, Aggerholm, Anni, Kjeldsen, Eigil, Roug, Anne S., Hokland, Peter, Nederby, Line

Source: Bill, M, Aggerholm, A, Kjeldsen, E, Roug, A S, Hokland, P & Nederby, L 2019, ' Revisiting CLEC12A as leukaemic stem cell marker in AML : highlighting the necessity of precision diagnostics in patients eligible for targeted therapy ', British Journal of Haematology, vol. 184, no. 5, pp. 769-781 . https://doi.org/10.1111/bjh.15711

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11

Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Authors: Theelen, Willemijn S. M. E., Kuilman, Thomas, Schulze, Katja, Zou, Wei, Krijgsman, Oscar, Peters, Dennis D. G. C., Cornelissen, Sten, Monkhorst, Kim, Sarma, Pranamee, Sumiyoshi, Teiko, Amler, Lukas C., Willems, Stefan M., Blaauwgeers, Johannes L. G., van Noesel, Carel J. M., Peeper, Daniel S., van den Heuvel, Michel M., Kowanetz, Marcin

Contributors: PMB medici, AII - Cancer immunology, CCA - Cancer biology and immunology, Pathology

Source: PLoS ONE, Vol 14, Iss 5, p e0216864 (2019)
PLoS ONE
PLoS ONE, 14(5). Public Library of Science
PLoS ONE, 14(5). PUBLIC LIBRARY SCIENCE
PLoS ONE, 14(5):e0216864. Public Library of Science
PLoS One, 14

Subject Terms: Medicine, Science, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Journal Article, Research Article, Biology and Life Sciences, Genetics, Gene Expression, Medicine and Health Sciences, Oncology, Cancers and Neoplasms, Lung and Intrathoracic Tumors, Non-Small Cell Lung Cancer, Molecular Biology, Molecular Biology Techniques, Molecular Biology Assays and Analysis Techniques, Gene Expression and Vector Techniques, Protein Expression, Research and Analysis Methods, Histochemistry and Cytochemistry Techniques, Immunohistochemistry Techniques, Immunologic Techniques, Cell biology, Cellular types, Animal cells, Blood cells, White blood cells, T cells, Cytotoxic T cells, Immune cells, Immunology, Immune Response, Mutation, Insertion Mutation, Biomarkers, Biochemistry, Genetics and Molecular Biology(all), Adult, Aged, Aged, 80 and over, B7-H1 Antigen/genetics, CD8-Positive T-Lymphocytes/immunology, Carcinoma, Non-Small-Cell Lung/genetics, Female, Gene Expression Regulation, Neoplastic/immunology, Humans, Immunity, Cellular, Interferon-gamma/genetics, Lung Neoplasms/genetics, Male, Middle Aged, Neoplasm Proteins/genetics, Neoplasm Staging, Programmed Cell Death 1 Receptor/genetics, Signal Transduction/genetics, Multidisciplinary, Lung cancer, medicine.disease, medicine, Biology, Cancer research, Immunohistochemistry, Cytotoxic T cell, Regulation of gene expression, Cancer immunotherapy, medicine.medical_treatment, Immune system, Gene expression, CD8, 80 and over, Carcinoma, Non-Small-Cell Lung/genetics, Gene Expression Regulation, Neoplastic/immunology, Immunity, Cellular

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12

Shared heritability and functional enrichment across six solid cancers

Authors: Elisa V. Bandera, Patricia A. Ganz, Kim De Ruyck, Simon A. Gayther, Natalia V. Bogdanova, Stephen B. Gruber, Nadine Tung, Martha L. Slattery, Hiltrud Brauch, Barbara Burwinkel, Esther M. John, Florian Heitz, Bogdan Pasaniuc, Jenny Lester, Fergus J. Couch, Nhu D. Le, Maria A. Caligo, Stella Koutros, Amit D. Joshi, Stephen J. Chanock, Noralane M. Lindor, Elza Khusnutdinova, Hermann Brenner, David G. Huntsman, Catharine M L West, Gad Rennert, Anna deFazio, Mattias Johansson, Aage Haugen, Darya Prokofyeva, Li Li, Jeri Kim, Paul A. Townsend, Olufunmilayo I. Olopade, Miguel E. Aguado-Barrera, Kjell Grankvist, David E. Goldgar, Douglas F. Easton, Amanda B. Spurdle, Michael T. Parsons, Shelley S. Tworoger, Robert J. Hamilton, Eitan Friedman, Renée T. Fortner, Karoline Kuchenbaecker, Pascal Guénel, Rosalind A. Eeles, Xia Jiang, Radka Kaneva, Jonathan Tyrer, Angela Cox, Paul Brennan, Rayjean J. Hung, Celine M. Vachon, Carolina Ellberg, Shanbeh Zienolddiny, Ana Osorio, Richard S. Houlston, Els Van Nieuwenhuysen, Graham Casey, Penella J. Woll, Heike Bickeböller, Catherine M. Phelan, Amanda E. Toland, Davor Lessel, Drakoulis Yannoukakos, Andy R Ness, Erich H-Wichmann, Andrew Berchuck, V. Wendy Setiawan, Nawaid Usmani, Xifeng Wu, Lorelei A. Mucci, Jeffrey N. Weitzel, Daniel D. Buchanan, Gregory Idos, Stig E. Bojesen, Gabriella Cadoni, Matthew B. Schabath, Philip Lazarus, David J. Hunter, Diether Lambrechts, Eunjung Lee, Loic Le Marchand, Alkes L. Price, Marcia Cruz Correa, Kari Stefansson, Kathleen Claes, Marc Tischkowitz, Sara Benlloch, Catherine M. Tangen, Lesley McGuffog, Estrid Høgdall, Jacek Gronwald, Angela Risch, Stephanie L. Schmit, Kamila Czene, Kristan J. Aronson, Taymaa May, Rosa B. Barkardottir, Karin Sundfeldt, Ulrike Peters, Ralf Bützow, Joe Dennis, M. Dawn Teare, Melissa C. Southey, Elizabeth J. van Rensburg, Robert J. MacInnis, Beth Y. Karlan, Annika Lindblom, Rebecca Sutphen, Jennifer Stone, Peter Hillemanns, Younghun Han, Carl Blomqvist, Julia A. Knight, Jolanta Kupryjanczyk, Lovise Maehle, Fotios Loupakis, Mary Anne Rossing, Mary Beth Terry, Jenny Chang-Claude, Adonina Tardón, Austin Miller, Lisa A. Cannon-Albright, Barry S. Rosenstein, Steven Gallinger, Alison M. Dunning, Jochen Hampe, Tee Kay-Khaw, Christiane Maier, Clarice R. Weinberg, Marco Montagna, Claudine Isaacs, Corina Lesseur, Susan L. Neuhausen, Jeroen R. Huyghe, Christopher A. Haiman, Montserrat Garcia-Closas, Susanne K. Kjaer, Christian F. Singer, Jyotsna Batra, Katherine L. Nathanson, Mark S. Goldberg, Roger L. Milne, Paul D.P. Pharoah, Erin M. Siegel, Geoffrey Liu, Hedy S. Rennert, Melinda C. Aldrich, Robert L. Ferris, Qin Wang, Brenda Diergaarde, Chul Yun-Hong, Emily White, Wilbert H.M. Peters, Kyriaki Michailidou, Manjeet K. Bolla, Elinor J. Sawyer, Eloiza H. Tajara, Susan J. Ramus, Sara Lindström, Florentia Fostira, Marc T. Goodman, Olivia Fletcher, Li Hsu, John L. Hopper, Francesmary Modugno, Ali Amin Al Olama, Ellen L. Goode, Mary B. Daly, Christopher K. Edlund, James McKay, Neil E. Caporaso, Marjanka K. Schmidt, Pooja Middha, Flavio Lejbkowicz, Miranda Pring, J. Margriet Collée, Liene Nikitina-Zake, Harvey A. Risch, Anna Jakubowska, Edith Olah, Daniel R. Barnes, Kathryn L. Terry, Amanda I. Phipps, Børge G. Nordestgaard, Anna Marie Mulligan, David V. Conti, Arto Mannermaa, Marjorie J. Riggan, Penelope M. Webb, Stephen N. Thibodeau, Matthias W. Beckmann, Zsofia Kote-Jarai, Hilary K. Finucane, Ute Hamann, Jack A. Taylor, Jong Y. Park, Peter J. Hulick, Thilo Dörk, Christopher I. Amos, Richa Saxena, Jane C. Figueiredo, Daniele Campa, Andrew T. Chan, Kenneth Muir, Victoria L. Stevens, Chu Chen, Orland Diez, Miriam Dwek, Lambertus A. Kiemeney, Monique J. Roobol, Johanna Schleutker, Kirsten B. Moysich, Karina Dalsgaard Sørensen, Mark A. Jenkins, Tanja Pejovic, Judy Garber, Hoda Anton-Culver, Aocs Mod SQuaD, D. Gareth Evans, André Lopes Carvalho, Robert Winqvist, Anthony J. Swerdlow, Maria Teresa Landi, Freddie C. Hamdy, Julie M. Cunningham, Triantafillos Liloglou, Sara Margolin, Håkan Olsson, Fredrik Wiklund, Alfons Meindl, Antonis C. Antoniou, Jenny L Donovan, David E. Neal, Anna H. Wu, Niclas Håkansson, Argyrios Ziogas, Dijana Plaseska-Karanfilska, Mark C. Weissler, Tabea Kühl, Peter A. Fasching, Sue A. Ingles, Georgia Chenevix-Trench, Andrew K. Godwin, Janet L. Stanford, Martin Lacko, Wei Zheng, Peter T. Campbell, Dale P. Sandler, Henrik Grönberg, Emmanouil Saloustros, Christopher I. Li, Geraldine Cancel-Tassin, Stefania Boccia, Lisa F. Newcomb, Ian G. Campbell, Javier Benitez, Peter Kraft, Adam S. Kibel, Jacques Simard, Evgeny N. Imyanitov, Sonja I. Berndt, Leon Raskin, Jacqueline M. Lane, Alice S. Whittemore, Trinidad Caldés, Michael Hoffmeister, Nora Pashayan, Diana Eccles, Ruth C. Travis, Kristin K. Zorn, David C. Christiani, Finn C. Nielsen, Stephanie A. Bien, José Ángel García-Sáenz, Victor Moreno, Heli Nevanlinna, Sebastian Stintzing, Natalia N. Antonenkova, Stephanie J. Weinstein, Diana Torres, Alicja Wolk, Silvia Franceschi, Gary E. Goodman, Stephan Lam, Hans Brunnström, Eric J. Duell, Josef Heinz-Lenz, Douglas A. Levine, Cezary Cybulski, Kenneth Offit, Paolo Radice, Paul A. James, Angeline S. Andrew, Irene L. Andrulis, Rolando Herrero, Polly A. Newcomb, Banu Arun, Andrew F. Olshan, Graham G. Giles, Mark H. Greene, Michael O. Woods, Robert L. Nussbaum, Mark N. Brook, Weiva Sieh, Hardev Pandha, Susanne M. Arnold, Fredrick R. Schumacher, Hongbing Shen, Frank Claessens, Mikael Johansson, Swe-Brca, Per Hall, Ana Vega, James D. Brenton, Manolis Kogevinas, Manuela Gago-Dominguez, Demetrius Albanes, Mads Thomassen, Peter Devilee, Linda E. Kelemen, Joan Brunet, Goska Leslie, Kathryn L. Penney, Cornelia M. Ulrich, Jan Lubinski, Digna R. Velez Edwards, Vessela N. Kristensen, Mia M. Gaudet, Manuel R. Teixeira, Line Bjørge, Duncan Thomas, Judith A. Clements

Contributors: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University, Læknadeild (HÍ), Faculty of Medicine (UI), Lífvísindasetur (HÍ), Biomedical Center (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Institut Català de la Salut, [Jiang X] Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. [Finucane HK] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [Schumacher FR] Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. Seidman Cancer Center, University Hospitals, Cleveland, OH, USA. [Schmit SL] Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. [Tyrer JP] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. [Han Y] Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. [Diez O] Grup d'Oncogenètica, Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain, Hospital Universitari Vall d'Hebron, Cancer Research (UK ), NIHR Comprehensive Biomedical Research Centre, Guy ’ s & St. Thomas ’ NHS Foundation Trust, Oxford Biomedical Research Centre, German Cancer Research Center, Consejo Nacional de Ciencia y Tecnología (CONACyT), King ’ s College London, National Health and Medical Research Council of Australia, Canadian Institutes of Health Research (CIHR), The BREast Oncology GAlician Network (BREOGAN, Dietmar-Hopp Foundation, Helmholtz Society and the German Cancer Research Center (DKFZ), Asociación Española Contra el Cáncer, University of Helsinki, Clinicum, University of Helsinki, Department of Pathology, University of Helsinki, Department of Obstetrics and Gynecology

Source: Scientia
Jiang, X, Finucane, H K, Schumacher, F R, Schmit, S L, Tyrer, J P, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, K B, Dennis, J, Conti, D V, Casey, G, Gaudet, M M, Huyghe, J R, Albanes, D, Aldrich, M C, Andrew, A S, Andrulis, I L, Anton-Culver, H, Antoniou, A C, Antonenkova, N N, Arnold, S M, Aronson, K J, Arun, B K, Bandera, E V, Barkardottir, R B, Barnes, D R, Batra, J, Beckmann, M W, Benitez, J, Benlloch, S, Berchuck, A, Berndt, S I, Bickeböller, H, Bien, S A, Blomqvist, C, Boccia, S, Bogdanova, N V, Bojesen, S E, Bolla, M K, Brauch, H, Brenner, H, Brenton, J D, Brook, M N, Brunet, J, Brunnström, H, Buchanan, D D, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, M A, Campbell, I, Campbell, P T, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, A L, Chan, A T, Chang-Claude, J, Chanock, S J, Chen, C, Christiani, D C, Claes, K B M, Claessens, F, Clements, J, Collée, J M, Correa, M C, Couch, F J, Cox, A, Cunningham, J M, Cybulski, C, Czene, K, Daly, M B, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, J L, Dörk, T, Duell, E J, Dunning, A M, Dwek, M, Eccles, D M, Edlund, C K, Edwards, D R V, Ellberg, C, Evans, D G, Fasching, P A, Ferris, R L, Liloglou, T, Figueiredo, J C, Fletcher, O, Fortner, R T, Fostira, F, Franceschi, S, Friedman, E, Gallinger, S J, Ganz, P A, Garber, J, García-Sáenz, J A, Gayther, S A, Giles, G G, Godwin, A K, Goldberg, M S, Goldgar, D E, Goode, E L, Goodman, M T, Goodman, G, Grankvist, K, Greene, M H, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, F C, Hamilton, R J, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M, Høgdall, E, Hong, Y-C, Hopper, J L, Houlston, R, Hulick, P J, Hunter, D J, Huntsman, D G, Idos, G, Imyanitov, E N, Ingles, S A, Isaacs, C, Jakubowska, A, James, P, Jenkins, M A, Johansson, M, Johansson, M, John, E M, Joshi, A D, Kaneva, R, Karlan, B Y, Kelemen, L E, Kühl, T, Khaw, K-T, Khusnutdinova, E, Kibel, A S, Kiemeney, L A, Kim, J, Kjaer, S K, Knight, J A, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, V N, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, M T, Lazarus, P, Le, N D, Lee, E, Lejbkowicz, F, Lenz, H-J, Leslie, G, Lessel, D, Lester, J, Levine, D A, Li, L, Li, C I, Lindblom, A, Lindor, N M, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, L L, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, R L, MacInnis, R J, Modugno, F, Montagna, M, Moreno, V, Moysich, K B, Mucci, L, Muir, K, Mulligan, A M, Nathanson, K L, Neal, D E, Ness, A R, Neuhausen, S L, Nevanlinna, H, Newcomb, P A, Newcomb, L F, Nielsen, F C, Nikitina-Zake, L, Nordestgaard, B G, Nussbaum, R L, Offit, K, Olah, E, Olama, A A A, Olopade, O I, Olshan, A F, Olsson, H, Osorio, A, Pandha, H, Park, J Y, Pashayan, N, Parsons, M T, Pejovic, T, Penney, K L, Peters, W H M, Phelan, C M, Phipps, A I, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, S J, Raskin, L, Rennert, G, Rennert, H S, van Rensburg, E J, Riggan, M J, Risch, H A, Risch, A, Roobol, M J, Rosenstein, B S, Rossing, M A, De Ruyck, K, Saloustros, E, Sandler, D P, Sawyer, E J, Schabath, M B, Schleutker, J, Schmidt, M K, Setiawan, V W, Shen, H, Siegel, E M, Sieh, W, Singer, C F, Slattery, M L, Sorensen, K D, Southey, M C, Spurdle, A B, Stanford, J L, Stevens, V L, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, A J, Tajara, E H, Tangen, C M, Tardon, A, Taylor, J A, Teare, M D, Teixeira, M R, Terry, M B, Terry, K L, Thibodeau, S N, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, A E, Torres, D, Townsend, P A, Travis, R C, Tung, N, Tworoger, S S, Ulrich, C M, Usmani, N, Vachon, C M, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, M E, Wang, Q, Webb, P M, Weinberg, C R, Weinstein, S, Weissler, M C, Weitzel, J N, West, C M L, White, E, Whittemore, A S, Wichmann, H-E, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, A H, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, K K, Lane, J M, Saxena, R, Thomas, D, Hung, R J, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, R A, Chenevix-Trench, G, Brennan, P J, Haiman, C A, Simard, J, Easton, D F, Gruber, S B, Pharoah, P D P, Price, A L, Pasaniuc, B, Amos, C I, Kraft, P & Lindström, S 2019, ' Shared heritability and functional enrichment across six solid cancers ', Nature Communications, vol. 10, no. 1, 431, pp. 1-23 . https://doi.org/10.1038/s41467-018-08054-4
Jiang, X, Finucane, H K, Schumacher, F R, Schmit, S L, Tyrer, J P, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, K B, Dennis, J, Conti, D V, Casey, G, Gaudet, M M, Huyghe, J R, Albanes, D, Aldrich, M C, Andrew, A S, Andrulis, I L, Anton-Culver, H, Antoniou, A C, Antonenkova, N N, Arnold, S M, Aronson, K J, Arun, B K, Bandera, E V, Barkardottir, R B, Barnes, D R, Batra, J, Beckmann, M W, Benitez, J, Benlloch, S, Berchuck, A, Berndt, S I, Bickeböller, H, Bien, S A, Blomqvist, C, Boccia, S, Bogdanova, N V, Bojesen, S E, Bolla, M K, Brauch, H, Brenner, H, Brenton, J D, Brook, M N, Brunet, J, Brunnström, H, Buchanan, D D, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, M A, Campbell, I, Campbell, P T, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, A L, Chan, A T, Chang-Claude, J, Chanock, S J, Chen, C, Christiani, D C, Claes, K B M, Claessens, F, Clements, J, Collée, J M, Correa, M C, Couch, F J, Cox, A, Cunningham, J M, Cybulski, C, Czene, K, Daly, M B, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, J L, Dörk, T, Duell, E J, Dunning, A M, Dwek, M, Eccles, D M, Edlund, C K, Edwards, D R V, Ellberg, C, Evans, D G, Fasching, P A, Ferris, R L, Liloglou, T, Figueiredo, J C, Fletcher, O, Fortner, R T, Fostira, F, Franceschi, S, Friedman, E, Gallinger, S J, Ganz, P A, Garber, J, García-Sáenz, J A, Gayther, S A, Giles, G G, Godwin, A K, Goldberg, M S, Goldgar, D E, Goode, E L, Goodman, M T, Goodman, G, Grankvist, K, Greene, M H, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, F C, Hamilton, R J, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M, Høgdall, E, Hong, Y-C, Hopper, J L, Houlston, R, Hulick, P J, Hunter, D J, Huntsman, D G, Idos, G, Imyanitov, E N, Ingles, S A, Isaacs, C, Jakubowska, A, James, P, Jenkins, M A, Johansson, M, Johansson, M, John, E M, Joshi, A D, Kaneva, R, Karlan, B Y, Kelemen, L E, Kühl, T, Khaw, K-T, Khusnutdinova, E, Kibel, A S, Kiemeney, L A, Kim, J, Kjaer, S K, Knight, J A, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, V N, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, M T, Lazarus, P, Le, N D, Lee, E, Lejbkowicz, F, Lenz, H-J, Leslie, G, Lessel, D, Lester, J, Levine, D A, Li, L, Li, C I, Lindblom, A, Lindor, N M, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, L L, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, R L, MacInnis, R J, Modugno, F, Montagna, M, Moreno, V, Moysich, K B, Mucci, L, Muir, K, Mulligan, A M, Nathanson, K L, Neal, D E, Ness, A R, Neuhausen, S L, Nevanlinna, H, Newcomb, P A, Newcomb, L F, Nielsen, F C, Nikitina-Zake, L, Nordestgaard, B G, Nussbaum, R L, Offit, K, Olah, E, Olama, A A A, Olopade, O I, Olshan, A F, Olsson, H, Osorio, A, Pandha, H, Park, J Y, Pashayan, N, Parsons, M T, Pejovic, T, Penney, K L, Peters, W H M, Phelan, C M, Phipps, A I, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, S J, Raskin, L, Rennert, G, Rennert, H S, van Rensburg, E J, Riggan, M J, Risch, H A, Risch, A, Roobol, M J, Rosenstein, B S, Rossing, M A, De Ruyck, K, Saloustros, E, Sandler, D P, Sawyer, E J, Schabath, M B, Schleutker, J, Schmidt, M K, Setiawan, V W, Shen, H, Siegel, E M, Sieh, W, Singer, C F, Slattery, M L, Sorensen, K D, Southey, M C, Spurdle, A B, Stanford, J L, Stevens, V L, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, A J, Tajara, E H, Tangen, C M, Tardon, A, Taylor, J A, Teare, M D, Teixeira, M R, Terry, M B, Terry, K L, Thibodeau, S N, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, A E, Torres, D, Townsend, P A, Travis, R C, Tung, N, Tworoger, S S, Ulrich, C M, Usmani, N, Vachon, C M, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, M E, Wang, Q, Webb, P M, Weinberg, C R, Weinstein, S, Weissler, M C, Weitzel, J N, West, C M L, White, E, Whittemore, A S, Wichmann, H-E, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, A H, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, K K, Lane, J M, Saxena, R, Thomas, D, Hung, R J, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, R A, Chenevix-Trench, G, Brennan, P J, Haiman, C A, Simard, J, Easton, D F, Gruber, S B, Pharoah, P D P, Price, A L, Pasaniuc, B, Amos, C I, Kraft, P & Lindström, S 2019, ' Shared heritability and functional enrichment across six solid cancers ', Nature Communications, vol. 10, no. 1, 431 . https://doi.org/10.1038/s41467-018-08054-4
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Nature communications, vol 10, iss 1
Nature Communications, 10
Nature Communications, Vol 10, Iss 1, Pp 1-23 (2019)
Jiang, X, Lindström, S & et al. 2019, ' Shared heritability and functional enrichment across six solid cancers ', Nature Communications, vol. 10, no. 1, 431 . https://doi.org/10.1038/s41467-018-08054-4
Nature Communications
Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan P; Han, Younghun; et al.(2019). Shared heritability and functional enrichment across six solid cancers. NATURE COMMUNICATIONS, 10(1), 431. doi: 10.1038/s41467-018-08054-4. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/42x44002
NATURE COMMUNICATIONS
Jiang, X, Finucane, H K, Schumacher, F R, Schmit, S L, Tyrer, J P, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, K B, Dennis, J, Conti, D V, Casey, G, Gaudet, M M, Huyghe, J R, Albanes, D, Aldrich, M C, Andrew, A S, Andrulis, I L, Anton-Culver, H, Antoniou, A C, Antonenkova, N N, Arnold, S M, Aronson, K J, Arun, B K, Bandera, E V, Barkardottir, R B, Barnes, D R, Batra, J, Beckmann, M W, Benitez, J, Benlloch, S, Berchuck, A, Berndt, S I, Bickeböller, H, Bien, S A, Blomqvist, C, Boccia, S, Bogdanova, N V, Bojesen, S E, Bolla, M K, Brauch, H, Brenner, H, Brenton, J D, Brook, M N, Brunet, J, Brunnström, H, Buchanan, D D, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, M A, Campbell, I, Campbell, P T, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, A L, Chan, A T, Chang-Claude, J, Chanock, S J, Chen, C, Christiani, D C, Claes, K B M, Claessens, F, Clements, J, Collée, J M, Correa, M C, Couch, F J, Cox, A, Cunningham, J M, Cybulski, C, Czene, K, Daly, M B, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, J L, Dörk, T, Duell, E J, Dunning, A M, Dwek, M, Eccles, D M, Edlund, C K, Edwards, D R V, Ellberg, C, Evans, D G, Fasching, P A, Ferris, R L, Liloglou, T, Figueiredo, J C, Fletcher, O, Fortner, R T, Fostira, F, Franceschi, S, Friedman, E, Gallinger, S J, Ganz, P A, Garber, J, García-Sáenz, J A, Gayther, S A, Giles, G G, Godwin, A K, Goldberg, M S, Goldgar, D E, Goode, E L, Goodman, M T, Goodman, G, Grankvist, K, Greene, M H, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, F C, Hamilton, R J, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M, Høgdall, E, Hong, Y-C, Hopper, J L, Houlston, R, Hulick, P J, Hunter, D J, Huntsman, D G, Idos, G, Imyanitov, E N, Ingles, S A, Isaacs, C, Jakubowska, A, James, P, Jenkins, M A, Johansson, M, Johansson, M, John, E M, Joshi, A D, Kaneva, R, Karlan, B Y, Kelemen, L E, Kühl, T, Khaw, K-T, Khusnutdinova, E, Kibel, A S, Kiemeney, L A, Kim, J, Kjaer, S K, Knight, J A, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, V N, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, M T, Lazarus, P, Le, N D, Lee, E, Lejbkowicz, F, Lenz, H-J, Leslie, G, Lessel, D, Lester, J, Levine, D A, Li, L, Li, C I, Lindblom, A, Lindor, N M, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, L L, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, R L, MacInnis, R J, Modugno, F, Montagna, M, Moreno, V, Moysich, K B, Mucci, L, Muir, K, Mulligan, A M, Nathanson, K L, Neal, D E, Ness, A R, Neuhausen, S L, Nevanlinna, H, Newcomb, P A, Newcomb, L F, Nielsen, F C, Nikitina-Zake, L, Nordestgaard, B G, Nussbaum, R L, Offit, K, Olah, E, Olama, A A A, Olopade, O I, Olshan, A F, Olsson, H, Osorio, A, Pandha, H, Park, J Y, Pashayan, N, Parsons, M T, Pejovic, T, Penney, K L, Peters, W H M, Phelan, C M, Phipps, A I, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, S J, Raskin, L, Rennert, G, Rennert, H S, van Rensburg, E J, Riggan, M J, Risch, H A, Risch, A, Roobol, M J, Rosenstein, B S, Rossing, M A, De Ruyck, K, Saloustros, E, Sandler, D P, Sawyer, E J, Schabath, M B, Schleutker, J, Schmidt, M K, Setiawan, V W, Shen, H, Siegel, E M, Sieh, W, Singer, C F, Slattery, M L, Sorensen, K D, Southey, M C, Spurdle, A B, Stanford, J L, Stevens, V L, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, A J, Tajara, E H, Tangen, C M, Tardon, A, Taylor, J A, Teare, M D, Teixeira, M R, Terry, M B, Terry, K L, Thibodeau, S N, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, A E, Torres, D, Townsend, P A, Travis, R C, Tung, N, Tworoger, S S, Ulrich, C M, Usmani, N, Vachon, C M, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, M E, Wang, Q, Webb, P M, Weinberg, C R, Weinstein, S, Weissler, M C, Weitzel, J N, West, C M L, White, E, Whittemore, A S, Wichmann, H-E, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, A H, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, K K, Lane, J M, Saxena, R, Thomas, D, Hung, R J, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, R A, Chenevix-Trench, G, Brennan, P J, Haiman, C A, Simard, J, Easton, D F, Gruber, S B, Pharoah, P D P, Price, A L, Pasaniuc, B, Amos, C I, Kraft, P & Lindström, S 2019, ' Shared heritability and functional enrichment across six solid cancers ', Nature Communications, vol. 10, no. 1, pp. 431 . https://doi.org/10.1038/s41467-018-08054-4

Subject Terms: Biolääketieteet - Biomedicine, Syöpätaudit - Cancers, Cancer, Cancer genetics, Epidemiology, Genomics, Brjóstakrabbamein, Krabbamein, Erfðafræði, Erfðarannsóknir, Faraldsfræði, Codi genètic, Càncer - Aspectes genètics, Càncer - Estudi de casos, Neoplasms [DISEASES], Other subheadings::Other subheadings::/genetics [Other subheadings], Other subheadings::Other subheadings::Other subheadings::/ethnology [Other subheadings], Genetic Phenomena::Inheritance Patterns [PHENOMENA AND PROCESSES], Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Case-Control Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT], Neoplasias [ENFERMEDADES], Otros calificadores::Otros calificadores::/genética [Otros calificadores], Otros calificadores::Otros calificadores::Otros calificadores::/etnología [Otros calificadores], Fenómenos Genéticos::Patrón de Herencia [FENÓMENOS Y PROCESOS], técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de casos y controles [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Breast Neoplasms, Case-Control Studies, Colorectal Neoplasms, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasms, Humans, Lung Neoplasms, Male, Mental Disorders, Neoplasm Proteins, Ovarian Neoplasms, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Smoking, Inheritance Patterns, Càncer -- Etiologia, Cancer -- Etiology, Breast Neoplasms/diagnosis, Colorectal Neoplasms/diagnosis, Head and Neck Neoplasms/diagnosis, Lung Neoplasms/diagnosis, Mental Disorders/ethnology, Neoplasm Proteins/genetics, Ovarian Neoplasms/diagnosis, Prostatic Neoplasms/diagnosis, Smoking/ethnology, Heritability, Colorectal cancer, medicine.disease, medicine, Cancer Etiology, Biology, Internal medicine, medicine.medical_specialty, Lung cancer, Prostate cancer, Genetic correlation, Oncology, Ovarian cancer, Càncer, Etiologia, Etiology, GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, BREAST-CANCER, RISK-FACTORS, LUNG-CANCER, PARTITIONING HERITABILITY, MENDELIAN RANDOMIZATION, GENETIC ARCHITECTURE, ANALYSES IDENTIFY, CELL-TYPES, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology, 3122 Cancers, Técnicas de Investigación::Métodos Epidemiológicos::Características de Estudios Epidemiológicos::Estudios Epidemiológicos::Estudios de Casos y Controles [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Medical Genetics, Medicinsk genetik, Càncer -- Aspectes genètics, Polymorphism, Single Nucleotide, Prevention, Breast Cancer, Genetics, Rare Diseases, Lung Cancer, Human Genome, Colo-Rectal Cancer, Digestive Diseases, Lung, MD Multidisciplinary, fenómenos genéticos::patrones de herencia [FENÓMENOS Y PROCESOS], lcsh:Science, lcsh:Q, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Breast cancer, ICEP, Centre for Surgical Research, Article, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, solid cancers, heritability, enrichment, head and neck, Settore MED/42 - IGIENE GENERALE E APPLICATA, Medicine and Health Sciences, Biology and Life Sciences, Science

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https://trepo.tuni.fi//handle/10024/116270

13

Synovial sarcoma: when epigenetic changes dictate tumour development

Authors: Nicolo Riggi, Ivan Stamenkovic, Luisa Cironi

Source: Swiss medical weekly, vol. 148, pp. w14667

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https://doi.emh.ch/smw.2018.14667

14

Predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort:a retrospective-prospective blinded study

Source: Buhl, A S K, Christensen, T D, Christensen, I J, Nelausen, K M, Balslev, E, Knoop, A S, Brix, E H, Svensson, E, Glavicic, V, Luczak, A, Langkjer, S T, Linnet, S, Jakobsen, E H, Bogovic, J, Ejlertsen, B, Rasmussen, A, Hansen, A, Knudsen, S, Nielsen, D & Jensen, P B 2018, ' Predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort : a retrospective-prospective blinded study ', Breast Cancer Research and Treatment, vol. 172, no. 2, pp. 391–400 . https://doi.org/10.1007/s10549-018-4918-4
Breast Cancer Research and Treatment
Buhl, A S K, Christensen, T D, Christensen, I J, Nelausen, K M, Balslev, E, Knoop, A S, Brix, E H, Svensson, E, Glavicic, V, Luczak, A, Langkjer, S T, Linnet, S, Jakobsen, E H, Bogovic, J, Ejlertsen, B, Rasmussen, A, Hansen, A, Knudsen, S, Nielsen, D & Jensen, P B 2018, ' Predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort : a retrospective-prospective blinded study ', Breast Cancer Research and Treatment, vol. 172, no. 2, pp. 391-400 . https://doi.org/10.1007/s10549-018-4918-4

Subject Terms: Advanced breast cancer, Epirubicin, Precision medicine, Predictive biomarker, Clinical Trial, Adult, Aged, Biomarkers, Pharmacological, Breast Neoplasms/drug therapy, Disease Progression, Disease-Free Survival, Epirubicin/administration & dosage, Female, Gene Expression Regulation, Neoplastic/drug effects, Humans, Middle Aged, Neoplasm Proteins/genetics, Proportional Hazards Models, Prospective Studies, RNA, Messenger/genetics, Retrospective Studies, Journal Article, Cancer Research, Oncology, medicine.drug, medicine, Prospective cohort study, Cancer, medicine.disease, Internal medicine, medicine.medical_specialty, Breast cancer, Clinical endpoint, business.industry, business, Cohort, Hazard ratio, Proportional hazards model