Showing 1 - 20 results of 24 for search '"Multiple Myeloma immunology"', query time: 1.18s Refine Results
2
Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A

Authors: Willy A. Noort, Harry C. Schouten, Marcel G.J. Tilanus, Richard W.J. Groen, Gerard M. J. Bos, Y.‐P. Xu, Michel van Gelder, Anton C.M. Martens, Subhashis Sarkar, Lotte Wieten, Wilfred T. V. Germeraad, Kasper M.A. Rouschop

Contributors: Promovendi ODB, MUMC+: BC - Hematologie, Interne Geneeskunde, Radiotherapie, MUMC+: B&L Weefseltypering, MUMC+: B&L TI Staf, RS: GROW - Oncology, RS: GROW - R3 - Basic and Translational Cancer Biology, RS: GROW - R2 - Innovative Cancer Diagnostics & Therapy, Hematology laboratory, CCA - Innovative therapy, CCA - Quality of life

Source: Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 64(8), 951-963. Springer
Cancer Immunology and Immunotherapy, 64(8), 951-63. Springer Science and Business Media Deutschland GmbH

Subject Terms: Original Article, NK cell, Multiple myeloma, HLA, Immunotherapy, KIR, NKG2A, Cancer Research, Oncology, Immunology, Immunology and Allergy, Interleukin 12, Cell therapy, Lymphokine-activated killer cell, Degranulation, Interleukin 21, Bone marrow, medicine.anatomical_structure, medicine, NK-92, NK Cell Lectin-Like Receptor Subfamily C, Biology, Animals, Cell Degranulation, Cell Line, Tumor, Cell Separation/methods, Coculture Techniques, Cytotoxicity, Immunologic, DNA-Binding Proteins/genetics, Flow Cytometry, Histocompatibility Antigens Class I/immunology, Humans, Immunotherapy/methods, Interleukin-2/immunology, Killer Cells, Natural/immunology, Mice, Mice, Knockout, Multiple Myeloma/immunology, NK Cell Lectin-Like Receptor Subfamily C/immunology, Neoplasm Transplantation, Oxygen/metabolism

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http://europepmc.org/articles/PMC4506464

3
CARs in the Lead Against Multiple Myeloma

Authors: Marcela V. Maus, Matthew J. Frigault, Felipe Bedoya, Maria Ormhøj

Source: Ormhøj, M, Bedoya, F, Frigault, M J & Maus, M V 2017, ' CARs in the Lead Against Multiple Myeloma ', Current Hematologic Malignancy Reports, vol. 12, no. 2, pp. 119–125 . https://doi.org/10.1007/s11899-017-0373-2

Subject Terms: Adoptive T cell therapy, B cell maturation antigen, Chimeric antigen receptor, Clinical trials, Multiple myeloma, Recombinant Fusion Proteins/genetics, Antigens, Neoplasm/immunology, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes/immunology, Humans, Multiple Myeloma/immunology, Immunotherapy, Adoptive/adverse effects, Treatment Outcome, Clinical Trials as Topic, T-Cell Antigen Receptor Specificity/immunology, Article, Cancer Research, Oncology, Hematology, Stem cell, T cell, medicine.anatomical_structure, medicine, Myeloma protein, Internal medicine, medicine.medical_specialty, Immunology, medicine.disease, business.industry, business, Cancer research, CD19, biology.protein, biology, Antigen, hemic and lymphatic diseases, immune system diseases

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https://findresearcher.sdu.dk:8443/ws/files/141803497/CARs_in_the_Lead_Against_Multiple_Myeloma.pdf

4
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

Authors: Overdijk, Marije B., Jansen, J. H. Marco, Nederend, Maaike, Lammerts van Bueren, Jeroen J., Groen, Richard W. J., Parren, Paul W. H. I., Leusen, Jeanette H. W., Boross, Peter

Contributors: Hematology laboratory, CCA - Cancer biology

Source: Overdijk, M B, Jansen, J H M, Nederend, M, van Bueren, J J L, Groen, R W J, Parren, P W H I, Leusen, J H W & Boross, P 2016, ' The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking ', Journal of Immunology, vol. 197, no. 3, pp. 807-813 . https://doi.org/10.4049/jimmunol.1501351
Journal of Immunology, 197(3), 807-13. American Association of Immunologists
Journal of Immunology, 197(3), 807. American Association of Immunologists

Subject Terms: ADP-ribosyl Cyclase 1, Animals, Antibodies, Monoclonal/pharmacology, Antibody-Dependent Cell Cytotoxicity/immunology, Antineoplastic Agents/pharmacology, Apoptosis/drug effects, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Multiple Myeloma/immunology, Receptors, IgG/drug effects, Tumor Cells, Cultured, Journal Article, Immunology, Immunology and Allergy, CD38, Receptor, In vitro, Programmed cell death, In vivo, Cell biology, Daratumumab, Biology, Monoclonal antibody, medicine.drug_class, medicine, Isatuximab

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https://portal.findresearcher.sdu.dk/da/publications/d67d8686-0e6a-48e1-93f6-6d4f4806e64a

5
Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance

Authors: Tineke Aarts-Riemens, Julie H. Huang, Jana Jakubikova, Sanne J. de Haart, Richard W.J. Groen, Douglas W. McMillin, Tuna Mutis, Constantine S. Mitsiades, Huipin Yuan, Henk M. Lokhorst, Anton C.M. Martens, Niels Bovenschen, Niels W.C.J. van de Donk, Monique C. Minnema

Contributors: Hematology, Hematology laboratory

Source: Clinical Cancer Research, 19(20), 5591-601. American Association for Cancer Research Inc.

Subject Terms: Cancer Research, Oncology, Bortezomib, medicine.drug, medicine, Bone marrow, medicine.anatomical_structure, Immune system, Cancer research, Granzyme B, Tumor microenvironment, Cytotoxic T cell, Biology, Immunology, Stromal cell, Multiple myeloma, medicine.disease, Animals, Antineoplastic Agents/therapeutic use, Cell Adhesion/immunology, Cell Communication, Cell Line, Tumor, Combined Modality Therapy, Cytotoxicity, Immunologic, Disease Models, Animal, Humans, Imidazoles/therapeutic use, Immunomodulation, Immunotherapy, Adoptive, Mice, Multiple Myeloma/immunology, Naphthoquinones/therapeutic use, T-Lymphocytes, Cytotoxic/immunology, Tumor Microenvironment/immunology, Xenograft Model Antitumor Assays, fas Receptor/metabolism, Cell Line, Tumor, Cytotoxicity, Immunologic, Disease Models, Animal, Immunotherapy, Adoptive, T-Lymphocytes, Cytotoxic/immunology

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https://syndication.highwire.org/content/doi/10.1158/1078-0432.CCR-12-3676

7
Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

Authors: Maarten E. Emmelot, Henk M. Lokhorst, Henk Rozemuller, Bianka Martini, Tuna Mutis, Gert Storm, Richard W.J. Groen, Teun Guichelaar, Anton C.M. Martens

Contributors: Hematology laboratory, Hematology

Source: Clinical Cancer Research, 19(6), 1467-75. American Association for Cancer Research Inc.

Subject Terms: Cancer Research, Oncology, Lymphocyte, medicine.anatomical_structure, medicine, Bone marrow, Transplantation, Ex vivo, Stromal cell, Biology, Immunology, Stem cell, Multiple myeloma, medicine.disease, Interleukin, Animals, Bone Marrow Cells/cytology, Female, Graft vs Host Disease/immunology, Graft vs Tumor Effect, Humans, Interleukin-17/immunology, Interleukin-6/immunology, Leukocytes, Mononuclear/cytology, Mice, Multiple Myeloma/immunology, Stromal Cells/cytology, T-Lymphocyte Subsets/cytology, T-Lymphocytes, Regulatory/cytology, Transplantation, Homologous, chemical and pharmacologic phenomena, hemic and immune systems

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https://syndication.highwire.org/content/doi/10.1158/1078-0432.CCR-12-2177

9
Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

Authors: Inger S. Nijhof, Yannis Morel, Paul W. H. I. Parren, Pascale Andre, B. van Kessel, N W C J van de Donk, T. Mutis, J. J. L. van Bueren, H M Lokhorst

Contributors: Hematology, Hematology laboratory, CCA - Innovative therapy

Source: Haematologica, 100(2), 263-268. Ferrata Storti Foundation
Nijhof, I S, Lammerts van Bueren, J J, van Kessel, B, Andre, P, Morel, Y, Lokhorst, H M, van de Donk, N W, Parren, P W & Mutis, T 2015, ' Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide ', Haematologica, vol. 100, no. 2, pp. 263-268 . https://doi.org/10.3324/haematol.2014.117531

Subject Terms: Hematology, Cytotoxicity, Biology, Immune system, Bone marrow, medicine.anatomical_structure, medicine, Immunology, Monoclonal, Lenalidomide, medicine.drug, Antibody, biology.protein, Daratumumab, Multiple myeloma, medicine.disease, Articles, Antibodies, Monoclonal/administration & dosage, Antibody-Dependent Cell Cytotoxicity/immunology, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Blotting, Western, Cell Proliferation, Cells, Cultured, Cytotoxicity, Immunologic/immunology, Drug Synergism, Flow Cytometry, Humans, Immunoglobulin G/immunology, Immunophenotyping, Killer Cells, Natural/immunology, Multiple Myeloma/immunology, Polymorphism, Genetic/genetics, RNA, Messenger/genetics, Real-Time Polymerase Chain Reaction, Receptors, IgG/genetics, Receptors, KIR/genetics, Reverse Transcriptase Polymerase Chain Reaction, Thalidomide/administration & dosage

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https://research.vumc.nl/en/publications/c13eee17-fa2a-4fa7-8efe-a25eee378540

10
Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

Authors: Drent, Esther, Groen, Richard W. J., Noort, Willy A., Themeli, Maria, van Bueren, Jeroen J. Lammerts, Parren, Paul W. H. I., Kuball, Jurgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W. C. J., Martens, Anton C. M., Lokhorst, Henk M., Mutis, Tuna

Contributors: Hematology laboratory, CCA - Cancer immunology, AII - Cancer immunology, Hematology

Source: Haematologica, 101(5), 616-625. Ferrata Storti Foundation
Drent, E, Groen, R W J, Noort, W A N, Themeli, M, van Bueren, J J L, Parren, P W H I, Kuball, J, Sebestyen, Z, Yuan, H, de Bruijn, J D, van de Donk, N W C J, Martens, A C M, Lokhorst, H M & Mutis, T 2016, ' Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma ', Haematologica, vol. 101, no. 5, pp. 616-625 . https://doi.org/10.3324/haematol.2015.137620
Haematologica, 101(5), 616. Ferrata Storti Foundation

Subject Terms: Journal Article, ADP-ribosyl Cyclase 1/genetics, Animals, Cytokines/biosynthesis, Cytotoxicity, Immunologic, Disease Models, Animal, Flow Cytometry, Gene Expression, Gene Transfer Techniques, Genes, Transgenic, Suicide, Hematopoietic Stem Cells/metabolism, Humans, Immunotherapy, Lymphocyte Activation/immunology, Mice, Mice, Knockout, Multiple Myeloma/immunology, Receptors, Antigen, T-Cell/genetics, Recombinant Fusion Proteins, T-Lymphocytes/immunology, Transduction, Genetic, Tumor Burden/genetics, Article, Hematology, Suicide gene, Adoptive cell transfer, Myeloid, medicine.anatomical_structure, medicine, Immunology, Chimeric antigen receptor, CD34, Antigen, Cancer immunotherapy, medicine.medical_treatment, Biology, hemic and lymphatic diseases, immune system diseases, hemic and immune systems

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11
Reconstructing the human hematopoietic niche in immunodeficient mice: Opportunities for studying primary multiple myeloma

Authors: Henk Rozemuller, Joost D. de Bruijn, Jan Jacob Schuringa, Reinier Raymakers, Petra Moerer, Michel de Weers, Henk-Jan Prins, Tuna Mutis, Huipin Yuan, Willy A. Noort, Paul W. H. I. Parren, Henk M. Lokhorst, Arjan Buijs, Berris van Kessel, Frans M. A. Hofhuis, Ellen van Binsbergen, Jeroen F. van Velzen, Andries C. Bloem, Richard W.J. Groen, Anton C.M. Martens, Linda Aalders

Contributors: Biomaterials Science and Technology, Faculty of Science and Technology, Faculteit Medische Wetenschappen/UMCG, Stem Cell Aging Leukemia and Lymphoma (SALL), Hematology laboratory, Hematology

Source: Blood, 120(3), e9-e16. American Society of Hematology
Blood, 120(3), E9-E16. AMER SOC HEMATOLOGY

Subject Terms: METIS-288455, IR-81834, BONE-MARROW, STEM-CELLS, MODEL, GROWTH, PATHOGENESIS, DISEASE, SYSTEM, MICROENVIRONMENT, PATHOPHYSIOLOGY, HALLMARKS, Cell Biology, Hematology, Immunology, Biochemistry, Bone marrow, medicine.anatomical_structure, medicine, Stem cell, Cancer research, Chemotherapy regimen, Niche, Multiple myeloma, medicine.disease, In vivo, Progenitor cell, Biology, Haematopoiesis, Animals, DNA-Binding Proteins/genetics, Disease Models, Animal, Ear Ossicles/cytology, Hematopoietic Stem Cell Transplantation/methods, Hematopoietic Stem Cells/cytology, Humans, Immunologic Deficiency Syndromes/genetics, Mice, Mice, Mutant Strains, Multiple Myeloma/immunology, Neoplasm Transplantation, Osteolysis/immunology, Stem Cell Niche/immunology, Tissue Scaffolds, Transplantation Chimera/immunology, Transplantation, Heterologous, Tumor Microenvironment/immunology

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https://research.utwente.nl/en/publications/reconstructing-the-human-hematopoietic-niche-in-immunodeficient-mice-opportunities-for-studying-primary-multiple-myeloma(e76cd7a7-6f7c-4271-a38a-bf82dd244714).html

12
Human neutrophils express immunoglobulin E (IgE)-binding proteins (Mac- 2/epsilon BP) of the S-type lectin family: role in IgE-dependent activation

Authors: Valérie Gruart, Sylvie Loiseau, J P Kusnierz, Monique Capron, Marie-José Truong, André Capron, J P Papin

Contributors: Centre d'immunologie et de biologie parasitaire [Lille] (CIBP), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Source: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 1993, 177 (1), pp.243-248. ⟨10.1084/jem.177.1.243⟩

Subject Terms: Articles, anti-ige, antigens, immunoglobulin e, lectin, neutrophils, antibodies, cd23 antigen, multiple myeloma, flow cytometry, galectin 3, MESH: Antigens, Differentiation/analysis, MESH: Antigens, Differentiation/genetics, MESH: Precipitin Tests, MESH: RNA, Messenger/analysis, MESH: Antigens, Differentiation/physiology, MESH: Flow Cytometry, MESH: Galectin 3, MESH: Humans, MESH: Immunoglobulin E/physiology, MESH: Multiple Myeloma/immunology, MESH: Neutrophils/immunology, MESH: Neutrophils/physiology, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, Immunology, Immunology and Allergy, Immunoglobulin E, biology.protein, biology, CD23, Polyclonal antibodies, Monoclonal antibody, medicine.drug_class, medicine, Binding protein, Antibody, Antigen, Respiratory burst, Molecular biology

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d6b7c42144244468782fb547ef3cc6
http://europepmc.org/articles/PMC2190867

14
Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

Authors: Ferlin, Martine, Noraz, Nelly, Hertogh, Catherine, Brochier, Jean, Taylor, Naomi, Klein, Bernard

Contributors: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Source: British Journal of Haematology
British Journal of Haematology, Wiley, 2000, 111 (2), pp.626--34. ⟨10.1046/j.1365-2141.2000.02364.x⟩

Subject Terms: Chemical Trans-Activators/metabolism, Western Cell Division/drug effects Cell Line DNA/biosynthesis DNA-Binding Proteins/metabolism Flow Cytometry Humans Insulin-Like Growth Factor I/*pharmacology Interleukin-6/*immunology MAP Kinase Signaling System/drug effects Multiple Myeloma/*immunology Phosphoproteins/metabolism Precipitin Tests STAT3 Transcription Factor Signal Transduction/*drug effects Stimulation, Apoptosis Blotting, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Hematology, Interleukin 6, biology.protein, biology, Chemistry, Cancer research, Transduction (genetics), Insulin-like growth factor, medicine.medical_treatment, medicine, Cytokine, Interleukin, Growth factor, Multiple myeloma, medicine.disease, STAT3, Glycoprotein 130, MAPK/ERK pathway

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9347b15ed1b0218c670f6dc9863a3224
https://hal.archives-ouvertes.fr/hal-02196817

15
GP130 cytokines, interferon, survival and proliferation of human myeloma cells

Authors: Klein, B.

Contributors: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Source: European Cytokine Network
European Cytokine Network, John Libbey Eurotext, 1997, 8 (3), pp.323

Subject Terms: CD/*physiology Cell Division Cell Survival Cytokine Receptor gp130 Cytokines/*physiology Humans Interferons/*physiology Interleukin-6/physiology Membrane Glycoproteins/*physiology Multiple Myeloma/*immunology/*pathology/therapy, Antigens, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

Access URL: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bbaae253ba3e497fd40c39763c4893d0
https://hal.archives-ouvertes.fr/hal-02194299

17
A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect

Authors: Henk Rozemuller, Mieke C. Zwart, Vivienne Verweij, Robbert M. Spaapen, Andries C. Bloem, Lijnie Bogers-Boer, Ellen van der Spek, Anton C.M. Martens, Richard W.J. Groen, Maarten E. Emmelot, Tuna Mutis, Henk M. Lokhorst

Contributors: Hematology laboratory, CCA - Cancer biology and immunology, Hematology, CCA - Treatment and quality of life

Source: Haematologica, 93(7), 1049. Ferrata Storti Foundation
Haematologica, 93(7), 1049-57. Ferrata Storti Foundation

Subject Terms: Animals, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Disease Progression, Graft vs Tumor Effect, Humans, Immunotherapy/methods, Luminescent Proteins/chemistry, Mice, Transgenic, Multiple Myeloma/immunology, Neoplasm Transplantation, Retroviridae/metabolism, Treatment Outcome, Hematology, Bioluminescence imaging, Medicine, business.industry, business, Tumor progression, Immunotherapy, medicine.medical_treatment, Peripheral blood mononuclear cell, Cell therapy, Internal medicine, medicine.medical_specialty, Multiple myeloma, medicine.disease, Pathology, Bone marrow, medicine.anatomical_structure, Cell Line, Tumor, Disease Models, Animal, Mice, Transgenic

File Description: image/pdf

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20
Electronic Resource
Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8+CD4+ T cells : evidence from myeloma-bearing mouse model

Source: Journal of Immunology

Index Terms: Adoptive Transfer, Animal, Animals, CD4-Positive T-Lymphocytes/ immunology, Cell Separation, Cytotoxicity, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunohistochemistry, Mice, Multiple Myeloma/ immunology, SCID, Tumor, Contribution to Journal

URL: https://eprints.qut.edu.au/74631/1/Freeman-2011-Myeloma-induced_allo.pdf
https://eprints.qut.edu.au/74631/1/Freeman-2011-Myeloma-induced_allo.pdf
doi:10.4049/jimmunol.1101202
Freeman, Lisa, Lam, Alfred, Petcu, E, Smith, Robert, Salajegheh, Ali, Diamond, Peter, Zannettino, Andrew, Evdokiou, Andreas, Luff, John, Wong, Pooi-Fong, Khalil, Dalia, Waterhouse, Nigel, Vari, Frank, Rice, Alison, Catley, Laurence, Hart, Derek, & Vuckovic, Slavica (2011) Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8+CD4+ T cells : evidence from myeloma-bearing mouse model. Journal of Immunology, 187(8), pp. 3987-3996.

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