Search Results - "Liver Neoplasms genetics"

1

Multiomics study of nonalcoholic fatty liver disease

Authors: Sisse Rye Ostrowski, Ole Birger Pedersen, Gardar Sveinbjornsson, Solvi Rognvaldsson, Henning Bundgaard, Gisli Halldorsson

Source: DBDS Genomic Consortium 2022, ' Multiomics study of nonalcoholic fatty liver disease ', Nature Genetics, vol. 54, no. 11, pp. 1652-1663 . https://doi.org/10.1038/s41588-022-01199-5

Subject Terms: Humans, Non-alcoholic Fatty Liver Disease/genetics, Proteomics, Genome-Wide Association Study, Liver/metabolism, Liver Cirrhosis/genetics, Liver Neoplasms/genetics, Genetics

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https://pure.au.dk/portal/da/publications/multiomics-study-of-nonalcoholic-fatty-liver-disease(0ef7997b-73b5-420e-accf-5d2eea901078).html

2

Novel deep learning-based solution for identification of prognostic subgroups in liver cancer (Hepatocellular carcinoma)

Authors: Anna Jurek-Loughrey, Kevin M. Prise, Caitríona E. McInerney, Alice R. Owens, Darragh G. McArt

Source: BMC Bioinformatics, Vol 22, Iss 1, Pp 1-22 (2021)
BMC Bioinformatics
Owens, A R, McInerney, C E, Prise, K M, McArt, D G & Jurek-Loughrey, A 2021, ' Novel deep learning-based solution for identification of prognostic subgroups in liver cancer (Hepatocellular carcinoma) ', BMC Bioinformatics, vol. 22, 563 . https://doi.org/10.1186/s12859-021-04454-4

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https://doi.org/10.1186/s12859-021-04454-4

3

Predictive Patterns of Glutamine Synthetase Immunohistochemical Staining in CTNNB1-mutated Hepatocellular Adenomas

Authors: Vincent Dunet, Charles Balabaud, Valérie Paradis, Paulette Bioulac-Sage, Annette S. H. Gouw, Christine Sempoux

Contributors: Groningen Institute for Organ Transplantation (GIOT)

Source: American Journal of Surgical Pathology, 45(4), 477-487. LIPPINCOTT WILLIAMS & WILKINS
The American journal of surgical pathology, vol. 45, no. 4, pp. 477-487

Subject Terms: beta-catenin–, activated hepatocellular adenoma, activated inflammatory hepatocellular adenoma, CD34, glutamine synthetase, hepatocellular adenoma, immunohistochemistry, inflammatory hepatocellular adenoma, molecular analysis, MALIGNANT-TRANSFORMATION, MOLECULAR CLASSIFICATION, CTTNB1 MUTATION, NEOPLASMS, CARCINOMA, INVASION, MARKERS, Adenoma, Liver Cell/enzymology, Adenoma, Liver Cell/genetics, Adenoma, Liver Cell/pathology, Adolescent, Adult, Aged, Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Biopsy, Needle, DNA Mutational Analysis, Europe, Exons, Female, Glutamate-Ammonia Ligase/analysis, Humans, Immunohistochemistry, Liver Neoplasms/enzymology, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Male, Middle Aged, Mutation, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Young Adult, beta Catenin/genetics, Pathology and Forensic Medicine, Surgery, Anatomy, Immunostaining, medicine.disease_cause, medicine, Adenoma, medicine.disease, Molecular biology, Biopsy, medicine.diagnostic_test, Malignant transformation, Hepatocellular adenoma, Exon, Biology

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https://research.rug.nl/en/publications/fbfefb97-661a-4aff-a123-a929e2f58f53

4

Adénomes hépatocellulaires : update 2020 [Hepatocellular adenoma: update 2020]

Authors: Romailler, E., Schmidt Kobbe, S., Moradpour, D., Sempoux, C.

Source: Revue medicale suisse, vol. 16, no. 704, pp. 1554-1559

Subject Terms: Adenoma, Liver Cell/diagnosis, Adenoma, Liver Cell/genetics, Adenoma, Liver Cell/pathology, Adenoma, Liver Cell/therapy, Female, Humans, Liver Neoplasms/diagnosis, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Liver Neoplasms/therapy, Magnetic Resonance Imaging, Mutation

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https://serval.unil.ch/notice/serval:BIB_308C528EE95A

5

Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma

Authors: Sciarra, A., Park, Y.N., Sempoux, C.

Source: Human pathology, vol. 96, pp. 48-55

Subject Terms: Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Biopsy, Carcinoma, Hepatocellular/chemistry, Carcinoma, Hepatocellular/genetics, Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/therapy, Cholangiocarcinoma/chemistry, Cholangiocarcinoma/genetics, Cholangiocarcinoma/pathology, Cholangiocarcinoma/therapy, Humans, Immunohistochemistry, Liver Neoplasms/chemistry, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Liver Neoplasms/therapy, Molecular Diagnostic Techniques, Neoplasms, Complex and Mixed/chemistry, Neoplasms, Complex and Mixed/genetics, Neoplasms, Complex and Mixed/pathology, Neoplasms, Complex and Mixed/therapy, Predictive Value of Tests, Prognosis, Cholangiocarcinoma, Cholangiolocarcinoma, Combined hepatocellular-cholangiocarcinoma, Hepatocellular carcinoma, Primary liver carcinoma, parasitic diseases

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https://serval.unil.ch/notice/serval:BIB_610E6C9C19DA

6

Inferring structural variant cancer cell fraction

Authors: Cmero, Marek, Yuan, Ke, Ong, Cheng Soon, Schröder, Jan, Corcoran, Niall M., Papenfuss, Tony, Hovens, Christopher M., Markowetz, Florian, Macintyre, Geoff, Adams, David J., Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D. L., Campbell, Peter J., Cao, Shaolong, Christie, Elizabeth L., Cun, Yupeng, Dawson, Kevin J., Demeulemeester, Jonas, Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew W., Garsed, Dale W., Gerstung, Moritz, Getz, Gad, Gonzalez, Santiago, Ha, Gavin, Haase, Kerstin, Imielinski, Marcin, Jerman, Lara, Ji, Yuan, Jolly, Clemency, Kleinheinz, Kortine, Lee, Juhee, Lee-Six, Henry, Leshchiner, Ignaty, Livitz, Dimitri, Malikic, Salem, Martincorena, Iñigo, Mitchell, Thomas J., Morris, Quaid D., Mustonen, Ville, Oesper, Layla, Peifer, Martin, Peto, Myron, Raphael, Benjamin J., Rosebrock, Daniel, Rubanova, Yulia, Sahinalp, S. Cenk, Salcedo, Adriana, Schlesner, Matthias, Schumacher, Steven E., Sengupta, Subhajit, Shi, Ruian, Shin, Seung Jun, Spellman, Paul T., Spiro, Oliver, Stein, Lincoln D., Tarabichi, Maxime, Van Loo, Peter, Vembu, Shankar, Vázquez-García, Ignacio, Wang, Wenyi, Wedge, David C., Wheeler, David A., Wintersinger, Jeffrey A., Yang, Tsun-Po, Yao, Xiaotong, Yu, Kaixian, Zhu, Hongtu

Contributors: Dentro, SC, Wedge, DC, Yang, T-P, Organismal and Evolutionary Biology Research Programme, Institute of Biotechnology, Bioinformatics, Department of Computer Science

Source: Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cmero, M, Yuan, K, Ong, C S, Schröder, J, Adams, D J, Anur, P, Beroukhim, R, Boutros, P C, Bowtell, D D L, Campbell, P J, Cao, S, Christie, E L, Cun, Y, Dawson, K J, Demeulemeester, J, Dentro, S C, Deshwar, A G, Donmez, N, Drews, R M, Eils, R, Fan, Y, Fittall, M W, Garsed, D W, Gerstung, M, Getz, G, Gonzalez, S, Ha, G, Haase, K, Imielinski, M, Jerman, L, Ji, Y, Jolly, C, Kleinheinz, K, Lee, J, Lee-Six, H, Leshchiner, I, Livitz, D, Malikic, S, Martincorena, I, Mitchell, T J, Morris, Q D, Mustonen, V, Oesper, L, Peifer, M, Peto, M, Raphael, B J, Rosebrock, D, Rubanova, Y, Sahinalp, S C, Salcedo, A, Schlesner, M, Schumacher, S E, Sengupta, S, Shi, R, Shin, S J, Spellman, P T, Spiro, O, Stein, L D, Tarabichi, M, Van Loo, P, Vembu, S, Vázquez-García, I, Wang, W, Wedge, D C, Wheeler, D A, Wintersinger, J A, Yang, T-P, Yao, X, Yu, K, Zhu, H, Corcoran, N M, Papenfuss, T, Hovens, C M, Markowetz, F & Macintyre, G 2020, ' Inferring structural variant cancer cell fraction ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-14351-8
essn: 2041-1723
nlmid: 101528555
Nature Communications

Subject Terms: PCAWG Evolution and Heterogeneity Working Group, PCAWG Consortium, Humans, Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Sensitivity and Specificity, Computational Biology, Gene Frequency, Genome, Human, Algorithms, Computer Simulation, Female, Male, DNA Copy Number Variations, Whole Genome Sequencing, Genome, Human, Rare Diseases, Cancer, Digestive Diseases, Human Genome, Genetics, Ovarian Cancer, ddc:610, lcsh:Science, lcsh:Q, Computational Biology/methods, Liver Neoplasms/genetics, Neoplasms/genetics, Ovarian Neoplasms/genetics, Pancreatic Neoplasms/genetics, Prostatic Neoplasms/genetics, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, medicine.disease, medicine, Allele frequency, Human genome, Biology, Whole genome sequencing, In silico, Breakpoint, Somatic evolution in cancer, Computational biology, Genetics & Genomics, Human Biology & Physiology, Ecology,Evolution & Ethology, Tumour Biology, Computational & Systems Biology, Science, Article, Computational biology and bioinformatics, Machine learning, 631/67, 631/114, 631/114/1305, 119, 129, 139, 45, 113 Computer and information sciences, 1181 Ecology, evolutionary biology, 1184 Genetics, developmental biology, physiology

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https://www.repository.cam.ac.uk/handle/1810/300096

7

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Contributors: Graduate School, Medical Oncology, Urology, Chemical Biology

Source: Nature Communications, 10
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, vol 10, iss 1
Nature communications, 10(1):5251. Nature Publishing Group
Nature Communications, 10:5251. Nature Publishing Group
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10(1):5251. Nature Publishing Group

Subject Terms: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Computational biology, Prostate cancer, medicine.disease, medicine, Microsatellite instability, Genotype, Tandem exon duplication, Whole genome sequencing, Tumor progression, Biology, Castration resistant, Prostate, medicine.anatomical_structure, lcsh:Science, lcsh:Q, Lymph Nodes, Humans, Bone Neoplasms, Liver Neoplasms, Soft Tissue Neoplasms, Prostatic Neoplasms, Neoplasm Metastasis, Cyclin-Dependent Kinases, Oncogene Proteins, Fusion, BRCA2 Protein, Receptors, Androgen, Male, Microsatellite Instability, Enhancer Elements, Genetic, DNA Copy Number Variations, Recombinational DNA Repair, Castration-Resistant, Whole Genome Sequencing, Chromatin Immunoprecipitation Sequencing, Biotechnology, Genetics, Cancer, Prostate Cancer, Urologic Diseases, Human Genome, SDG 3 - Good Health and Well-being, Article, Genetics research, Science, Physics and Astronomy(all), Chemistry(all), Biochemistry, Genetics and Molecular Biology(all), Journal Article, BRCA2 Protein/genetics, Bone Neoplasms/genetics, Cyclin-Dependent Kinases/genetics, Genetic/genetics, Liver Neoplasms/genetics, Fusion/genetics, Prostatic Neoplasms/genetics, Castration-Resistant/classification, Androgen/genetics, Recombinational DNA Repair/genetics, Soft Tissue Neoplasms/genetics, Enhancer Elements, Genetic/genetics, Oncogene Proteins, Fusion/genetics, Prostatic Neoplasms, Castration-Resistant/classification, Receptors, Androgen/genetics, Biochemistry, Genetics and Molecular Biology(all)

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075391947&origin=inward

8

Necroptosis microenvironment directs lineage commitment in liver cancer

Contributors: Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe labellisée Ligue contre le Cancer, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Universität Zürich [Zürich] = University of Zurich (UZH), Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), RWTH Aachen University, Vienna Biocenter - VBC [Austria], University of Tübingen, Heidelberg University Hospital [Heidelberg], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Cancer Consortium [Heidelberg] (DKTK), This work was supported by the ERC Consolidator Grant ‘CholangioConcept’ (to L.Z.), the German Research Foundation (DFG): grants FOR2314, SFB685, SFB/TR209 and the Gottfried Wilhelm Leibniz Program (to L.Z.). Further funding was provided by the German Ministry for Education and Research (BMBF) (e:Med/Multiscale HCC), the German Universities Excellence Initiative (third funding line: ‘future concept’), the German Center for Translational Cancer Research (DKTK), the German-Israeli Cooperation in Cancer Research (DKFZ-MOST) (to L.Z.) and the Intramural Research Program of the Centre for Cancer Research, National Cancer Institute, National Institutes of Health (to X.W.W.). The group of O.B. is supported by grants from ANR-BMFT, Fondation ARC pour la recherche sur le Cancer, INSERM, and the National Cancer Institute of the National Institutes of Health under Award Number R01CA136533. O.B. is a CNRS fellow., We thank E. Rist, P. Schiemann, C. Fellmeth, C.-J. Hsieh, D. Heide and J. Hetzer for technical help or assistance. We thank A. Weber for providing TLR2 and TLR4 knockout mice and W. S. Alexander and The Walter and Eliza Hall Institute of Medical Research for providing Mlklfl/fl mice. The Cas9n–p19Arf sgRNA vector was provided by W. Xue. We thank the c.ATG facility of Tuebingen University and CeGaT Tuebingen for exome sequencing and data analysis., Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), University of Zurich, Zender, Lars

Source: Nature
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩

Subject Terms: Cancer epigenetics, Cancer microenvironment, MESH: Animals, MESH: Apoptosis*/genetics, MESH: Cytokines/metabolism, MESH: DNA Transposable Elements/genetics, MESH: DNA-Binding Proteins/genetics, MESH: DNA-Binding Proteins/metabolism, MESH: Disease Models, Animal, MESH: Epigenesis, Genetic/genetics, MESH: Female, MESH: Gene Expression Profiling, MESH: Genes, myc, MESH: Genes, ras, MESH: Carcinogenesis/genetics, MESH: Hepatocytes/metabolism, MESH: Hepatocytes/pathology, MESH: Humans, MESH: Liver Neoplasms/genetics, MESH: Liver Neoplasms/pathology, MESH: Male, MESH: Mice, MESH: Mosaicism, MESH: Necrosis*/genetics, MESH: Proto-Oncogene Proteins c-akt/genetics, MESH: Carcinoma, Hepatocellular/genetics, MESH: T-Box Domain Proteins/genetics, MESH: T-Box Domain Proteins/metabolism, MESH: Transcription Factors/genetics, MESH: Transcription Factors/metabolism, MESH: Tumor Microenvironment, MESH: Carcinoma, Hepatocellular/pathology, MESH: Cell Differentiation, MESH: Cell Lineage*/genetics, MESH: Cholangiocarcinoma/genetics, MESH: Cholangiocarcinoma/pathology, MESH: Cyclin-Dependent Kinase Inhibitor p16/deficiency, [SDV.CAN]Life Sciences [q-bio]/Cancer, Multidisciplinary, Hepatic stellate cell, Cellular differentiation, Cancer research, Liver cancer, medicine.disease, medicine, Necroptosis, Biology, Context (language use), Epigenome, Tumor microenvironment, digestive system diseases, Article, 570 Life sciences, biology, 610 Medicine & health, 10239 Institute of Laboratory Animal Science, 1000 Multidisciplinary

File Description: Seehawer_2018_NATURE_Necroptosis_liver.pdf - application/pdf

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https://hal.archives-ouvertes.fr/hal-02348982

9

Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing

Authors: Estrid Høgdall, Hans Jørgen Nielsen, Per Ibsen, P. J. Heiberg Engel, P. N. Larsen, M. B. Mogensen, Finn Cilius Nielsen, Jens Ravn Eriksen, Lars N. Jorgensen, Ben Vainer, Olga Østrup, Per Jess, Maria Rossing, Morten Grauslund, Kell Østerlind

Source: BMC Cancer
Mogensen, M B, Rossing, M, Østrup, O, Larsen, P N, Heiberg Engel, P J, Jørgensen, L N, Hogdall, E V, Eriksen, J, Ibsen, P, Jess, P, Grauslund, M, Nielsen, H J, Nielsen, F C, Vainer, B & Osterlind, K 2018, ' Genomic alterations accompanying tumour evolution in colorectal cancer : tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing ', BMC Cancer, vol. 18, 752 . https://doi.org/10.1186/s12885-018-4639-4
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)

Subject Terms: Research Article, Colorectal cancer, Concordance, Metastatic cancer, Heterogeneity, Adult, Aged, Aged, 80 and over, Colorectal Neoplasms/drug therapy, DNA Copy Number Variations, Female, Genes, APC, Genomics, Humans, Liver Neoplasms/genetics, Male, Middle Aged, Mutation, Proto-Oncogene Proteins p21(ras)/genetics, Whole Exome Sequencing/methods, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Cancer Research, Genetics, Oncology, KRAS, medicine.disease_cause, medicine, Surgical oncology, medicine.medical_specialty, Exome sequencing, business.industry, business, Genomic Profile, medicine.disease, Internal medicine, Disease, Neuroblastoma RAS viral oncogene homolog

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http://europepmc.org/articles/PMC6053835

10

A Review of Circulating Tumor DNA in Hepatobiliary Malignancies

Authors: Kabir Mody, Sean P. Cleary

Source: Frontiers in Oncology, Vol 8 (2018)
Frontiers in Oncology

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https://www.frontiersin.org/article/10.3389/fonc.2018.00212/full

11

Development of a Liver-specific Tet-On Inducible System for AAV Vectors and Its Application in the Treatment of Liver Cancer

Authors: Lilianne Tenenbaum, Pedro Berraondo, Astrid Pañeda, Jesús Prieto, Stuart G. Beattie, Marianna Di Scala, Abdelwahed Chtarto, Irene Gil-Farina, Itziar Otano, Laura Blanco, Victor Baldim, Gloria González-Aseguinolaza, Lucia Vanrell

Source: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Molecular therapy : the journal of the American Society of Gene Therapy
Molecular therapy, 19 (7

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12

Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer

Authors: Mark A. Feitelson, Alla Arzumanyan, Zhaorui Lian, Irene Oi-Lin Ng, Enoch Kotei, Tiffany Friedman

Source: Oncogene

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7792f0db2c8c8f7804d5478dc19b2ba3
https://doi.org/10.1038/onc.2011.255

13

Wnt / β-Catenin-Signalweg in Fälle von hepatozellulären Karzinomen aus Kolumbien

Authors: Rocio Lopez, Iris Suarez M, Pierre Hainaut, Juan Camilo Pérez, Germán Osorio, Maria-C Navas, Diego Uribe, Sergio Hoyos, Carlos Mario Jaramillo, Pascal Pineau

Contributors: Grupo de Gastrohepatologia [Medellin, Colombia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Departamento de Patologia [Medellin, Colombia], Facultad de Psicología, Valencia, Hospital Pablo Tobón Uribe [Medellín, Colombie], Fundacion Santa Fe de Bogota [Colombia], International Prevention Research Institute (IPRI), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was funded by Departamento Nacional de Ciencia, Innovación y Tecnologia Colciencias (Grant 111540820471) and Proyecto de Sostenibilidad, Vicerrectoría de Investigación, Universidad de Antioquia., We thank Dr. Anne Lise Haenni from the Institut Jacques Monod for critical reading of the manuscript and Dr. Andres Arias from Universidad de Antioquia for discussion of the results. We also thank Ghyslaine Martel from International Agency for Research on Cancer (IARC) and Beatriz Vieco from Departamento de Patología, Universidad de Antioquia, for technical assistance.

Source: Annals of hepatology : official journal of the Mexican Association of Hepatology
Annals of hepatology : official journal of the Mexican Association of Hepatology, Elsevier, 2015, 14 (1), pp.64-74. ⟨10.1016/S1665-2681(19)30802-6⟩
Annals of Hepatology, Vol 14, Iss 1, Pp 64-74 (2015)

Subject Terms: β-catenin, CTNNB1, Mutation, HBV infection, HCC, Subcellular localization, MESH: Age Factors, MESH: Aged, MESH: Mutation, MESH: Neoplasm Grading, MESH: Aged, 80 and over, MESH: Retrospective Studies, MESH: Wnt Signaling Pathway / genetics, MESH: beta Catenin / genetics, MESH: beta Catenin / metabolism, MESH: Carcinoma, Hepatocellular / etiology, MESH: Carcinoma, Hepatocellular / genetics, MESH: Carcinoma, Hepatocellular / pathology, MESH: Hepatitis B, Chronic / complications, MESH: Cohort Studies, MESH: Colombia, MESH: Exons, MESH: Female, MESH: Humans, MESH: Immunohistochemistry, MESH: Liver Neoplasms / etiology, MESH: Liver Neoplasms / genetics, MESH: Liver Neoplasms / pathology, MESH: Male, MESH: Middle Aged, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, digestive system diseases, neoplasms, Hepatology, General Medicine, Biology, Hepatitis B, medicine.disease, medicine, Hepatocellular carcinoma, medicine.disease_cause, Carcinoma, Exon, Immunohistochemistry, Wnt signaling pathway, Pathology, medicine.medical_specialty, Cancer research, Gene, Specialties of internal medicine, RC581-951

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02863009

14

A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma

Authors: Fernando J. Corrales, José M. Mato, J.I. Riezu, Jesús Prieto, Bruno Sangro, Paul C. Schröder, Victor Segura, Enrique Santamaría

Source: Functional & Integrative Genomics. 11:419-429

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https://doi.org/10.1007/s10142-011-0230-7

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15

Le variant de l'Adiponutrine I148M est un facteur de risque de cancer du foie associé au VHC chez les patients nord-africains

Authors: Ezzikouri, Sayeh, Alaoui, Rhimou, Tazi, Sana, Nadir, Salwa, Elmdaghri, Naima, Pineau, Pascal, Benjelloun, Soumaya

Contributors: Laboratoire des Hépatites Virales [Casablanca, Maroc] (LHV), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), CHU Ibn Rochd [Casablanca], Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by The European Commission under the Health Cooperation Work Program of the 7th Framework Program for the Research and Technological Development, HepaCute Project (Grant Agreement No. 260844)., European Project: 260844,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,HEPACUTE(2010), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]

Source: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2014, 21, pp.179-183. ⟨10.1016/j.meegid.2013.11.005⟩

Subject Terms: Spontaneous clearance, PNPLA3, Hepatocellular carcinoma, Genetic marker, MESH: Aged, MESH: Carcinoma, Hepatocellular / epidemiology, MESH: Liver Cirrhosis / complications, MESH: Liver Cirrhosis / genetics, MESH: Liver Cirrhosis / virology, MESH: Liver Neoplasms / epidemiology, MESH: Liver Neoplasms / genetics, MESH: Liver Neoplasms / virology, MESH: Male, MESH: Membrane Proteins / genetics, MESH: Middle Aged, MESH: Morocco / epidemiology, MESH: Carcinoma, Hepatocellular / genetics, MESH: Polymorphism, Single Nucleotide, MESH: Risk Factors, MESH: Carcinoma, Hepatocellular / virology, MESH: Female, MESH: Gene Frequency, MESH: Genotype, MESH: Hepadnaviridae / physiology, MESH: Humans, MESH: Lipase / genetics, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02863287

16

Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma

Authors: Kevin Tak-Pan Ng, Chris K. Sun, ST Fan, T.K. Lee, Kwan Man, Chung Mau Lo, Ronnie Tp Poon

Source: British Journal of Cancer

Subject Terms: Cancer Research, Oncology, Liver cancer, medicine.disease, medicine, Cancer research, Pathology, medicine.medical_specialty, Hepatocellular carcinoma, Advanced stage, Metastasis, Hepatectomy, medicine.medical_treatment, Infiltration (medical), Messenger RNA, Blood vessel, medicine.anatomical_structure, business.industry, business, digestive system diseases, neoplasms, Molecular Diagnostics, hepatocellular carcinoma (HCC), Six1, hepatectomy, pathologic tumour-node-metastasis (pTNM) stage, venous infiltration, survival, Blotting, Western, Carcinoma, Hepatocellular - genetics - metabolism - pathology, Liver Neoplasms - genetics - metabolism - pathology, Homeodomain Proteins - genetics - metabolism, Cell Line, Tumor

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e258bf7d46786845e26ec38d6d41f7
https://doi.org/10.1038/sj.bjc.6603399

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17

Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma

Authors: M. Benazzouz, Soumaya Benjelloun, Abdellah Akil, Sayeh Ezzikouri, Rajaa Afifi, Pascal Pineau, Aziz Benjouad, Anne Dejean, Ama Gassama Diagne, Abdellah Essaid El Feydi

Contributors: Laboratoire des Hépatites Virales [Casablanca, Maroc] (LHV), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université Mohammed V, CHU Ibn-Sina [Rabat] (CHUIS), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by Pasteur Institute of Morocco and the Pasteur Institutes International Network (RIIP)., The authors would like to acknowledge all patients for their participation in this study., Université Mohammed V de Rabat [Agdal] (UM5)

Source: Cancer Epidemiology
Cancer Epidemiology, Elsevier, 2012, 36 (5), pp.e300-e305. ⟨10.1016/j.canep.2012.05.011⟩

Subject Terms: EP300, PCAF, Liver cancer, Genetic susceptibility, Histone acetyltransferases, MESH: Carcinoma, Hepatocellular / epidemiology, MESH: Carcinoma, Hepatocellular / genetics, MESH: Liver Neoplasms / epidemiology, MESH: Liver Neoplasms / genetics, MESH: Male, MESH: Markov Chains, MESH: Middle Aged, MESH: Morocco / epidemiology, MESH: Mutation, Missense, MESH: Odds Ratio, MESH: Polymorphism, Genetic, MESH: Polymorphism, Single Nucleotide, MESH: Case-Control Studies, MESH: Risk Factors, MESH: Sex Distribution, MESH: Sex Factors, MESH: p300-CBP Transcription Factors / genetics, MESH: Chromosomal Instability / genetics, MESH: E1A-Associated p300 Protein / genetics, MESH: Female, MESH: Gene Frequency, MESH: Genetic Predisposition to Disease / genetics, MESH: Genotype, MESH: Humans, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, digestive system diseases, Cancer Research, Oncology, Epidemiology, Population, education.field_of_study, education, Cancer research, Cancer, medicine.disease, medicine, business.industry, business, Genotype, Hepatocellular carcinoma, Genetic predisposition

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02863321

18

Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets.: Molecular Signature of Hepatosplenic T-cell Lymphoma

Authors: Françoise Berger, Marion Travert, Aurélien de Reyniès, Philippe Gaulard, Jacques Bosq, Marie-Hélène Delfau-Larue, Nadine Martin-Garcia, Jean Soulier, Elizabeth Macintyre, Laurence de Leval, Josette Brière, Yenlin Huang, Teresa Marafioti

Contributors: Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Department of Anatomic Pathology, Chang Gung Memorial Hospital [Taipei] (CGMH), Service de Pathologie Clinique, Université de Lausanne = University of Lausanne (UNIL)-Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV)-Institut Universitaire de Pathologie, Service d'immunologie biologique, Centre de Biologie et de Pathologie, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Hôpital Renée Sabran [CHU - HCL], Hospices Civils de Lyon (HCL), Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR), Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anatomo-pathologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie, dermatologie, oncologie, Oncodermatologie, immunologie et cellules souches cutanées (IDO (U976 / UMR_S 976)), Service hématologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Department of histopathology, University College Hospital, (le programme) Cartes d'identité des tumeurs (CIT), Ligue Nationales Contre le Cancer (LNCC), This work is part of the Carte d'Identité des Tumeurs (CIT) program (http://cit.liguecancer.net/index.php/en) from the Ligue Nationale Contre le Cancer and of the Tenomic project inserm-00730464, version 1 - 10 Sep 2012 supported by a Programme Hospitalier de Recherche Clinique and the Institut National du Cancer (INCa). This work was supported by the Institut National de la Santé et de la Recherche Médicale (INSERM), the Institut National du Cancer (INCa), the Plan cancer of the Belgian government, and the Association pour la Recherche Thérapeutique, Génétique et Immunologique dans les Lymphomes (ARTGIL). M.T. was supported by the Fondation pour la Recherche Médicale (DEQ 2010/0318253), Université de Lausanne (UNIL)-Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV)-Institut Universitaire de Pathologie, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]

Source: Blood
Blood, 2012, 119 (24), pp.5795-806. ⟨10.1182/blood-2011-12-396150⟩
Blood, American Society of Hematology, 2012, 119 (24), pp.5795-806. ⟨10.1182/blood-2011-12-396150⟩
Blood, vol. 119, no. 24, pp. 5795-5806

Subject Terms: MESH: Aged, MESH: Gene Expression Regulation, Neoplastic, MESH: Genes, Neoplasm, MESH: Humans, MESH: Intracellular Signaling Peptides and Proteins, MESH: Isochromosomes, MESH: Liver Neoplasms, MESH: Lymphoma, T-Cell, MESH: Male, MESH: Membrane Proteins, MESH: Middle Aged, MESH: Base Sequence, MESH: Molecular Sequence Data, MESH: Molecular Targeted Therapy, MESH: Protein-Tyrosine Kinases, MESH: Receptors, Antigen, T-Cell, alpha-beta, MESH: Receptors, Antigen, T-Cell, gamma-delta, MESH: Splenic Neoplasms, MESH: Tumor Markers, Biological, MESH: Young Adult, MESH: Adult, MESH: Cell Lineage, MESH: Chromosome Aberrations, MESH: Cluster Analysis, MESH: Crystallins, MESH: Drug Resistance, Neoplasm, MESH: Female, MESH: Gene Expression Profiling, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cell Biology, Hematology, Immunology, Biochemistry, CpG site, Tyrosine kinase, Biology, Hepatosplenic T-cell lymphoma, medicine.disease, medicine, Syk, Gene expression profiling, T-cell lymphoma, Cancer research, Lymphoma, T-cell receptor, Article, Adult, Aged, Base Sequence, Cell Lineage/genetics, Chromosome Aberrations, Cluster Analysis, Crystallins/metabolism, Drug Resistance, Neoplasm/genetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, Neoplasm/genetics, Humans, Intracellular Signaling Peptides and Proteins/antagonists & inhibitors, Intracellular Signaling Peptides and Proteins/metabolism, Isochromosomes/genetics, Liver Neoplasms/drug therapy, Liver Neoplasms/genetics, Lymphoma, T-Cell/drug therapy, Lymphoma, T-Cell/genetics, Male, Membrane Proteins/metabolism, Middle Aged, Molecular Sequence Data, Molecular Targeted Therapy, Protein-Tyrosine Kinases/antagonists & inhibitors, Protein-Tyrosine Kinases/metabolism, Receptors, Antigen, T-Cell, alpha-beta/genetics, Receptors, Antigen, T-Cell, gamma-delta/genetics, Splenic Neoplasms/drug therapy, Splenic Neoplasms/genetics, Tumor Markers, Biological/genetics, Tumor Markers, Biological/metabolism, Young Adult

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e780adf265c2d757a521986c9949edaf
https://www.hal.inserm.fr/inserm-00730464

19

Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122*

Authors: Patrick J. Collins, Carlos Fernández-Hernando, Angela M. Liu, Mingzhu Lu, Raquel de Sousa Abreu, Nathan D. Trinklein, Daniel R. Boutz, Luiz O. F. Penalva, John M. Luk, Edward M. Marcotte, Shelley Force Aldred, Cristina M. Ramírez, Bruce A. Shapiro, Yufei Huang, Uthra Suresh, Shu Yun Le

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f22f6e167c4860963b6c5811c586fc
https://europepmc.org/articles/PMC3093880/

20

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

Source: PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e20090 (2011)

Subject Terms: Gene Expression Profiling, Liver Neoplasms - genetics, Liver - metabolism - pathology, DNA Copy Number Variations, Carcinoma, Hepatocellular - genetics, Multidisciplinary, Copy-number variation, Cancer research, Carcinogenesis, medicine.disease_cause, medicine, Gene expression, Gene regulatory network, Somatic cell, Gene expression profiling, Gene, Genetics, Biology, Gene prediction, Research Article, Computational Biology, Genomics, Genome Analysis Tools, Genetic Networks, Genome Scans, Trait Locus Analysis, Genome Evolution, Genome Expression Analysis, Systems Biology, Cancer Genetics, Gene Networks, Genetics of Disease, Medicine, Gastroenterology and Hepatology, Oncology, Cancers and Neoplasms, Gastrointestinal Tumors, Hepatocellular Carcinoma, Basic Cancer Research, Science

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a4896b4d0988bb3c67d89df989bfa1
http://hdl.handle.net/10722/139743

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