Showing 1 - 20 results of 236 for search '"Histones metabolism"', query time: 1.25s Refine Results
1
Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

Authors: Marziyeh Tolouee, Koen D. W. Hendriks, Fia Fia Lie, Lucas P. Gartzke, Maaike Goris, Femke Hoogstra-Berends, Steven Bergink, Robert H. Henning

Contributors: Department of Sciences, Molecular Neuroscience and Ageing Research (MOLAR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC)

Source: Cell Transplantation, 31. SAGE Publishing
Cell Transplantation, 31, 1-12. SAGE Publishing
Cell Transplantation, 31:09636897221108705. SAGE Publishing

Subject Terms: reactive oxygen species, CONSEQUENCES, cooling, Swine, Adenosine Triphosphate/metabolism, Histones/metabolism, Biomedical Engineering, DNA, Cell Biology, 53BP1, gamma-H2Ax, APOPTOSIS, Histones, Oxidative Stress, Adenosine Triphosphate, HYDROGEN-PEROXIDE, Reactive Oxygen Species/metabolism, DNA strand breaks, INJURY, DNA/metabolism, Animals, DNA Damage, transplantation

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https://doi.org/10.1177/09636897221108705

3
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

Authors: Lisa Willemsen, Koen H.M. Prange, Annette E. Neele, Cindy P.A.A. van Roomen, Marion Gijbels, Guillermo R. Griffith, Myrthe den Toom, Linda Beckers, Ricky Siebeler, Nathanael J. Spann, Hung-Jen Chen, Laura A. Bosmans, Andrej Gorbatenko, Suzanne van Wouw, Noam Zelcer, Heinz Jacobs, Fred van Leeuwen, Menno P.J. de Winther

Contributors: RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: Carim - B07 The vulnerable plaque: makers and markers, Pathologie, Medical Biochemistry, ACS - Atherosclerosis & ischemic syndromes, AII - Inflammatory diseases, Graduate School, Center of Experimental and Molecular Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Diabetes & metabolism, Medical Biology

Source: Cell Reports, 41(8):111703. Cell Press
Cell reports, 41(8):111703. Cell Press

Subject Terms: Histone-Lysine N-Methyltransferase/metabolism, epigenetics, H3K79, Macrophages, Histones/metabolism, Histone-Lysine N-Methyltransferase, DOT1L, macrophage, Lipids, General Biochemistry, Genetics and Molecular Biology, Plaque, Atherosclerotic, Histones, immune system, Mice, inflammation, Macrophages/metabolism, lipid metabolism, Humans, Animals, CP: Molecular biology, methyltransferase, atherosclerosis, Plaque, Atherosclerotic

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05bb3dde3236461fb0442e54d9df7cd
https://cris.maastrichtuniversity.nl/en/publications/8e61cfc8-7c5e-4e6b-ab6b-cb1ba514a359

4
NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients:An Observational Study

Authors: Laure Morimont, Mélanie Dechamps, Clara David, Céline Bouvy, Constant Gillot, Hélène Haguet, Julien Favresse, Lorian Ronvaux, Julie Candiracci, Marielle Herzog, Pierre-François Laterre, Julien De Poortere, Sandrine Horman, Christophe Beauloye, Jonathan Douxfils

Contributors: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire

Source: Morimont, L, Dechamps, M, David, C, Bouvy, C, Gillot, C, Haguet, H, Favresse, J, Ronvaux, L, Candiracci, J, Herzog, M, Laterre, P-F, De Poortere, J, Horman, S, Beauloye, C & Douxfils, J 2022, ' NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients : An Observational Study ', Biomolecules, vol. 12, no. 8, 1038 . https://doi.org/10.3390/biom12081038
Biomolecules, Vol. 12, no.8, p. 1038 (2022)
Biomolecules, Vol. 12, no. 8, p. 1038 (2022)
Biomolecules; Volume 12; Issue 8; Pages: 1038

Subject Terms: Neutrophils, SARS-CoV-2, Extracellular Traps/metabolism, Histones/metabolism, COVID-19, Shock, Biomarkers/metabolism, Biochemistry, Extracellular Traps, Shock, Septic, Nucleosomes/metabolism, Shock, Septic/metabolism, Nucleosomes, Histones, Septic/metabolism, nucleosomes, septic shock, NETs’ formation, Humans, Neutrophils/metabolism, Molecular Biology, Biomarkers

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https://pure.unamur.be/ws/files/66869429/11924_2022_Morimont.pdf

5
Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

Authors: Corbeski, Ivan, Guo, Xiaohu, Eckhardt, Bruna V, Fasci, Domenico, Wiegant, Wouter, Graewert, Melissa A, Vreeken, Kees, Wienk, Hans, Svergun, Dmitri I, Heck, Albert J R, van Attikum, Haico, Boelens, Rolf, Sixma, Titia K, Mattiroli, Francesca, van Ingen, Hugo, Sub NMR Spectroscopy, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics

Contributors: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub NMR Spectroscopy, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics

Source: Science Advances, 8(30). AMER ASSOC ADVANCEMENT SCIENCE
Science advances, 8(30). American Association for the Advancement of Science (AAAS)
Science Advances
Science advances, 8(30). American Association for the Advancement of Science
Science advances 8(30), eabo0517 (2022). doi:10.1126/sciadv.abo0517

Subject Terms: Histones, Histone Chaperones/genetics, Multidisciplinary, DNA Repair, Histones/metabolism, Histone Chaperones, ddc:500, DNA, Molecular Chaperones/genetics, DNA/chemistry, Molecular Chaperones, Nucleosomes

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https://doi.org/10.1126/sciadv.abo0517

6
CREB-binding protein (CBP) gene family regulates planarian survival and stem cell differentiation

Authors: Rafael Romero, Sheila Cárcel, Judith Mazariegos, Coral Vivancos, Kerstin Bartscherer, Susanna Fraguas, Thileepan Sekaran, Jordi Ginés, Ma Dolores Molina, Francesc Cebrià

Contributors: Hubrecht Institute for Developmental Biology and Stem Cell Research

Source: Dipòsit Digital de la UB
Universidad de Barcelona
Developmental Biology, 476, 53-67. Academic Press

Subject Terms: Planària (Gènere), Cell type, Cellular differentiation, Cell Differentiation/genetics, Histones/metabolism, Stem cells, Histones, Chromatin/metabolism, 03 medical and health sciences, 0302 clinical medicine, Schmidtea mediterranea, Stem Cells/cytology, Regeneration, Animals, Transcription Factors/metabolism, CREB-binding protein, Molecular Biology, Cell Proliferation, 030304 developmental biology, CREB-Binding Protein/genetics, 0303 health sciences, biology, Regeneració (Biologia), Stem Cells, Cell Differentiation, Planarians, Cell Biology, biology.organism_classification, CREB-Binding Protein, Planarians/genetics, Chromatin, Planaria (Genus), Cell biology, Regeneration (Biology), Planarian, biology.protein, Regeneration/genetics, Stem cell, Cèl·lules mare, Developmental biology, 030217 neurology & neurosurgery, Transcription Factors, Developmental Biology

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https://doi.org/10.1016/j.ydbio.2021.02.008

7
Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration

Authors: Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang

Contributors: RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Source: Cell death & disease 13, 538 (2022). doi:10.1038/s41419-022-04985-5
Cell Death & Disease, 13(6):538. Nature Publishing Group

Subject Terms: Cartilage, Articular, EXPRESSION, Cancer Research, Immunology, Histones/metabolism, Histones, ENHANCER, Cellular and Molecular Neuroscience, Mice, Chondrocytes, Osteoarthritis, Humans, Animals, Knee/genetics, Chondrogenesis/genetics, Histone Demethylases, Polycomb Repressive Complex 2, Chondrocytes/metabolism, Cell Biology, Osteoarthritis, Knee, Polycomb Repressive Complex 2/metabolism, Articular/metabolism, Cartilage, Cartilage, Articular/metabolism, Histone Demethylases/genetics, Osteoarthritis, Knee/genetics, Chondrogenesis

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https://doi.org/10.1038/s41419-022-04985-5

8
Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome

Authors: Tessadori, Federico, Duran, Karen, Knapp, Karen, Fellner, Matthias, Deciphering Developmental Disorders Study, Smithson, Sarah, Beleza Meireles, Ana, Elting, Mariet W, Waisfisz, Quinten, O'Donnell-Luria, Anne, Nowak, Catherine, Douglas, Jessica, Ronan, Anne, Brunet, Theresa, Kotzaeridou, Urania, Svihovec, Shayna, Saenz, Margarita S, Thiffault, Isabelle, Del Viso, Florencia, Devine, Patrick, Rego, Shannon, Tenney, Jessica, van Haeringen, Arie, Ruivenkamp, Claudia A L, Koene, Saskia, Robertson, Stephen P, Deshpande, Charulata, Pfundt, Rolph, Verbeek, Nienke, van de Kamp, Jiddeke M, Weiss, Janneke M M, Ruiz, Anna, Gabau, Elisabeth, Banne, Ehud, Pepler, Alexander, Bottani, Armand, Laurent, Sacha, Guipponi, Michel, Bijlsma, Emilia, Bruel, Ange-Line, Sorlin, Arthur, Willis, Mary, Powis, Zoe, Smol, Thomas, Vincent-Delorme, Catherine, Baralle, Diana, Colin, Estelle, Revencu, Nicole, Calpena, Eduardo, Wilkie, Andrew O M, Chopra, Maya, Cormier-Daire, Valerie, Keren, Boris, Afenjar, Alexandra, Niceta, Marcello, Terracciano, Alessandra, Specchio, Nicola, Tartaglia, Marco, Rio, Marlene, Barcia, Giulia, Rondeau, Sophie, Colson, Cindy, Bakkers, Jeroen, Mace, Peter D, Bicknell, Louise S, van Haaften, Gijs

Contributors: Study, Deciphering Developmental Disorders, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de génétique médicale UCL, UCL - (SLuc) Centre de malformations vasculaires congénitales, Human genetics, Amsterdam Reproduction & Development (AR&D), Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Gastroenterology Endocrinology Metabolism, Hubrecht Institute for Developmental Biology and Stem Cell Research

Source: American journal of human genetics, Vol. 109, no.4, p. 750-758 (2022)
American journal of human genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 750-758
American Journal of Human Genetics, 109(4), 750-758. CELL PRESS
Deciphering Developmental Disorders Study 2022, ' Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome ', American journal of human genetics, vol. 109, no. 4, pp. 750-758 . https://doi.org/10.1016/j.ajhg.2022.02.003
American Journal of Human Genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 4, pp. 750-758

Subject Terms: Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], nucleosome, Histones/metabolism, DNA, Syndrome, zebrafish, neurodevelopmental disorder, Chromatin, Zebrafish/genetics, Histones, histone H4, intellectual disability, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Genetics, Animals, Humans, microcephaly, Zebrafish, Genetics (clinical)

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https://doi.org/10.1016/j.ajhg.2022.02.003

9
Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy

Authors: Yvan Arsenijevic, Maarten van Lohuizen, Dror Sharon, Francis L. Munier, Karine Schouwey, Adeline Berger, Martial Mbefo, Corinne Kostic, William A. Beltran, Hélène Dolfuss, Avigail Beryozkin, Xavier Gérard, Hoai Viet Tran

Source: International Journal of Molecular Sciences, Vol 22, Iss 9331, p 9331 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17
International journal of molecular sciences, vol. 22, no. 17, pp. 9331

Subject Terms: Retinal degeneration, Programmed cell death, QH301-705.5, Genetic enhancement, macromolecular substances, Biology, Gene mutation, Animals, DNA Methylation, Dogs, Enhancer of Zeste Homolog 2 Protein/genetics, Enhancer of Zeste Homolog 2 Protein/metabolism, Epigenesis, Genetic, Eye Proteins/physiology, Histones/genetics, Histones/metabolism, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Polycomb Repressive Complex 1/physiology, Proto-Oncogene Proteins/physiology, Retinal Degeneration/etiology, Retinal Degeneration/metabolism, Retinal Degeneration/pathology, Retinal Rod Photoreceptor Cells/metabolism, Retinal Rod Photoreceptor Cells/pathology, Retinitis Pigmentosa/etiology, Retinitis Pigmentosa/metabolism, Retinitis Pigmentosa/pathology, epigenetic, neuroprotection, polycomb-repressive complex, retinal degeneration, Catalysis, Article, Inorganic Chemistry, Histones, Retinal Rod Photoreceptor Cells, Proto-Oncogene Proteins, Gene expression, medicine, Enhancer of Zeste Homolog 2 Protein, Physical and Theoretical Chemistry, Biology (General), Eye Proteins, Molecular Biology, QD1-999, Spectroscopy, Polycomb Repressive Complex 1, Organic Chemistry, EZH2, General Medicine, medicine.disease, Computer Science Applications, Cell biology, Chemistry, Cell Death Process, Retinal Dystrophies, Retinitis Pigmentosa

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https://www.mdpi.com/1422-0067/22/17/9331

10
Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

Authors: Blaise Li, Martino Ugolini, Damarys Loew, Germano Cecere, Aleksei Samolygo, Céline Didier, Eric Cornes, Meetali Singh, Giorgia Barucci, Piergiuseppe Quarato, Florent Dingli

Contributors: Mécanismes de l'Hérédité épigénétique / Mechanisms of epigenetic inheritance, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Scuola Normale Superiore di Pisa (SNS), Moscow Institute of Physics and Technology [Moscow] (MIPT), Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie [Paris], This project has received funding from the Institut Pasteur, the CNRS and the European Research Council (ERC) under the EU Horizon 2020 research and innovation programme under grant agreement no. ERC-StG- 679243. G.B. is part of the Pasteur–Paris University (PPU) International PhD Program and has received funding from the EU Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 665807. E.C. was supported by a Pasteur-Cantarini Fellowship program. F.D. and D.L. have received funding from Région Ile-de-France and Fondation pour la Recherche Médicale grants to support this study, We thank the members of the Cecere laboratory, D. Canzio, N. Iovino, R. Sawarkar and P. Andersen for discussions of the manuscript, the Miska, the Mello, the Kennedy, the Seydoux, the Claycomb, the Strome and the Dumont laboratories for sharing strains and/or antibodies. Some strains were provided by the CGC, funded by NIH Office of Research Infrastructure Programs (P40 OD010440)., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Source: Nature cell biology
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩

Subject Terms: MESH: Gene Editing, MESH: CRISPR-Cas Systems, Small RNA, MESH: Argonaute Proteins / deficiency, MESH: Caenorhabditis elegans Proteins / metabolism, Inheritance Patterns, MESH: RNA, Small Interfering / genetics, MESH: Argonaute Proteins / metabolism, medicine.disease_cause, MESH: RNA, Antisense / genetics, MESH: Argonaute Proteins / genetics, Animals, Genetically Modified, Histones, 0302 clinical medicine, MESH: Histones / metabolism, MESH: Animals, RNA, Small Interfering, MESH: Caenorhabditis elegans / genetics, Caenorhabditis elegans, Gene Editing, 0303 health sciences, Mutation, MESH: RNA, Messenger / metabolism, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Biological Evolution, Cell biology, Histone, MESH: Fertility / genetics, 030220 oncology & carcinogenesis, Argonaute Proteins, Piwi RNAs, MESH: RNA, Messenger / genetics, MESH: Gene Silencing, Epigenetic memory, endocrine system, MESH: Mutation, MESH: Caenorhabditis elegans / metabolism, Piwi-interacting RNA, MESH: Biological Evolution, Biology, Article, MESH: Animals, Genetically Modified, 03 medical and health sciences, medicine, Animals, Gene silencing, RNA, Antisense, Gene Silencing, RNA, Messenger, MESH: RNA, Antisense / metabolism, Caenorhabditis elegans Proteins, Gene, Repetitive Sequences, Nucleic Acid, 030304 developmental biology, MESH: RNA, Small Interfering / metabolism, MESH: Repetitive Sequences, Nucleic Acid, MESH: Histones / genetics, urogenital system, RNA, Cell Biology, biology.organism_classification, Fertility, RNAi, biology.protein, MESH: Caenorhabditis elegans Proteins / genetics, MESH: Inheritance Patterns, CRISPR-Cas Systems

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b418c96155c11b9d0637d29c2e4f8
https://doi.org/10.1038/s41556-020-0462-7

11
Auxin-degron system identifies immediate mechanisms of OCT4

Authors: José C. R. Silva, Mariana R. P. Alves, Lawrence E. Bates

Contributors: Bates, Lawrence [0000-0002-2675-309X], Rebelo Da Silva, Jose [0000-0001-5487-1117], Apollo - University of Cambridge Repository

Source: Bates, L E, Alves, M R P & Silva, J C R 2021, ' Auxin-degron system identifies immediate mechanisms of OCT4 ', Stem Cell Reports, vol. 16, no. 7, pp. 1818-1831 . https://doi.org/10.1016/j.stemcr.2021.05.016
Stem Cell Reports

Subject Terms: 0301 basic medicine, Histones/metabolism, Oct4, Biochemistry, Genome, Nanog, Epigenesis, Genetic, Histones, Mice, 0302 clinical medicine, Transcription (biology), Cell Self Renewal, Induced pluripotent stem cell, reproductive and urinary physiology, Octamer Transcription Factor-3/metabolism, biology, Acetylation, Nanog Homeobox Protein, embryonic stem cells, Nanog Homeobox Protein/metabolism, Cell biology, Histone, embryonic structures, biological phenomena, cell phenomena, and immunity, Lysine/metabolism, Protein Binding, Homeobox protein NANOG, Pluripotent Stem Cells, Article, Cell Line, 03 medical and health sciences, Genetics, Animals, Enhancer, Transcription factor, mouse nPSCs, Indoleacetic Acids, Indoleacetic Acids/metabolism, Lysine, Cell Biology, auxin-inducible degron, Embryonic stem cell, 030104 developmental biology, Pluripotent Stem Cells/metabolism, biology.protein, Degron, Octamer Transcription Factor-3, 030217 neurology & neurosurgery, Pou5f1, Developmental Biology

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12
Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Authors: Geneviève Almouzni, Iva Simeonova

Contributors: Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Dynamique du noyau [Institut Curie], Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Source: Trends in Molecular Medicine
Trends in Molecular Medicine, Elsevier, 2019, 25 (11), pp.933-935. ⟨10.1016/j.molmed.2019.09.003⟩

Subject Terms: 0301 basic medicine, [SDV]Life Sciences [q-bio], MESH: Chromatin / metabolism, Histone Chaperones / metabolism, Histones / metabolism, Humans, Neoplasm Metastasis / pathology, Neoplasms / pathology, Regulator, Biology, Cell fate determination, Metastasis, Histones, 03 medical and health sciences, Histone H3, 0302 clinical medicine, Neoplasms, histone H3 dynamics, medicine, Histone Chaperones, metastasis, Neoplasm Metastasis, Molecular Biology, CAF-1, Invasive carcinoma, Transition (genetics), chromatin reprogramming, medicine.disease, Chromatin, 3. Good health, 030104 developmental biology, Cancer research, Molecular Medicine, 030217 neurology & neurosurgery

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b371ef5620dd6af5ff66e06c01b2dd6
https://doi.org/10.1016/j.molmed.2019.09.003

13
Integrative epigenetic taxonomy of primary prostate cancer

Authors: Andries M. Bergman, Eider Valle-Encinas, Seiwon Laura Chang, Karianne Schuurman, João Lobo, Rui Henrique, Felix Y. Feng, Carmen Jerónimo, Suzan Stelloo, Wilbert Zwart, Ekaterina Nevedomskaya, Oscar Krijgsman, Daniel S. Peeper, L. F. A. Wessels, Yongsoo Kim

Contributors: Pathology, Internal medicine, Institute for Complex Molecular Systems, Chemical Biology

Source: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, 9(1):4900. Nature Publishing Group UK
Nature Communications, 9(1)
Nature Communications, 9(1):4900. Nature Publishing Group
Nature Communications
Stelloo, S, Nevedomskaya, E, Kim, Y, Schuurman, K, Valle-Encinas, E, Lobo, J, Krijgsman, O, Peeper, D S, Chang, S L, Feng, F Y C, Wessels, L F A, Henrique, R, Jerónimo, C, Bergman, A M & Zwart, W 2018, ' Integrative epigenetic taxonomy of primary prostate cancer ', Nature Communications, vol. 9, no. 1, 4900 . https://doi.org/10.1038/s41467-018-07270-2

Subject Terms: 0301 basic medicine, Epigenomics, Male, Androgen/metabolism, Science, Histones/metabolism, General Physics and Astronomy, Receptors, Androgen/metabolism, Biology, SDG 3 – Goede gezondheid en welzijn, General Biochemistry, Genetics and Molecular Biology, Article, Carcinoma/metabolism, Epigenesis, Genetic, Histones, 03 medical and health sciences, Prostate cancer, Genetic, SDG 3 - Good Health and Well-being, Receptors, medicine, Humans, Epigenetics, lcsh:Science, Aged, Regulation of gene expression, Multidisciplinary, Sequence Analysis, RNA, Chromatin binding, Carcinoma, Wnt signaling pathway, Prostatic Neoplasms, General Chemistry, Middle Aged, Prostatic Neoplasms/metabolism, medicine.disease, 3. Good health, Androgen receptor, Molecular Typing, 030104 developmental biology, Receptors, Androgen, Cancer research, H3K4me3, RNA, lcsh:Q, Sequence Analysis, Epigenesis

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http://link.springer.com/article/10.1038/s41467-018-07270-2

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15
Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Authors: Kuroki, S., Nakai, Y., Maeda, R., Okashita, N., Akiyoshi, M., Yamaguchi, Y., Kitano, S., Miyachi, H., Nakato, R., Ichiyanagi, K., Shirahige, K., Kimura, Hiroshi, Shinkai, Y., Tachibana, M.

Source: Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 4, Pp 1340-1354 (2018)

Subject Terms: 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Euchromatin, Lysine/*metabolism, histone demethylation, Biochemistry, Demethylation, Histones, Mice, Histone-Lysine N-Methyltransferase/genetics/metabolism, Jumonji Domain-Containing Histone Demethylases/*deficiency/metabolism, lcsh:QH301-705.5, lcsh:R5-920, Gene Expression Regulation, Developmental, Embryo, Mouse Embryonic Stem Cells, Methylation, Down-Regulation/genetics, Cell biology, embryonic structures, lcsh:Medicine (General), transcription, Chromosomes, Mammalian/metabolism, Histones/*metabolism, Mutation/genetics, Cell Survival, Down-Regulation, Embryonic Development, Biology, histone methylation, Article, Cell Line, 03 medical and health sciences, Histone H3, Genetics, Animals, embryonic stem cell, Lysine, transcription /embryonic stem cell, Cell Biology, Epigenome, Cell Cycle Checkpoints, Histone-Lysine N-Methyltransferase, Embryonic stem cell, Chromosomes, Mammalian, 030104 developmental biology, lcsh:Biology (General), Epiblast, Mutation, Mouse Embryonic Stem Cells/cytology/*metabolism, Developmental Biology

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Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3c1919b43481572150b59f55092c82
http://europepmc.org/articles/PMC5998703

16
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

Authors: Petra Hamerlik, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Jannick Brennum, Jane Skjøth-Rasmussen, Mikkel Staberg, Mette Villingshøj, Henriette Pedersen, Hans Skovgaard Poulsen, Kamilla E. Jensen, Rikke Darling Rasmussen

Source: Staberg, M, Rasmussen, R D, Michaelsen, S R, Pedersen, H, Jensen, K E, Villingshøj, M, Skjoth-Rasmussen, J, Brennum, J, Vitting-Seerup, K, Poulsen, H S & Hamerlik, P 2018, ' Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B ', Molecular Oncology, vol. 12, no. 3, pp. 406-420 . https://doi.org/10.1002/1878-0261.12174
Molecular Oncology
Molecular Oncology, Vol 12, Iss 3, Pp 406-420 (2018)

Subject Terms: 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Cancer Research, Histones/metabolism, Apoptosis, Lomustine/administration & dosage, KDM2B, Astrocytes/metabolism, Histones, Jumonji Domain-Containing Histone Demethylases/genetics, Lomustine, Research Articles, Etoposide, biology, Brain Neoplasms, chemoresistance, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Glioblastoma/drug therapy, Antineoplastic Agents/administration & dosage, Chromatin, Histone, Oncology, Neoplastic Stem Cells, F-Box Proteins/genetics, Molecular Medicine, Research Article, Lysine/metabolism, Primary Cell Culture, Etoposide/administration & dosage, Antineoplastic Agents, Brain Neoplasms/drug therapy, lcsh:RC254-282, Cell Line, 03 medical and health sciences, Neoplastic Stem Cells/metabolism, histone demethylase, Glioma, Genetics, medicine, Humans, Epigenetics, Progenitor cell, epigenetics, F-Box Proteins, Lysine, Apoptosis/drug effects, glioblastoma, Cancer, cancer stem‐like cell, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Astrocytes, DNA Damage/drug effects, biology.protein, Cancer research, Demethylase, DNA Damage

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https://doi.org/10.1002/1878-0261.12174

17
Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast

Authors: Takuya Yoda, Koji Arikawa, Naoyuki Okada, Masahito Hosokawa, Hayato Tsuyuzaki, Haruko Takeyama, Masamitsu Sato

Contributors: Instituto de Investigação e Inovação em Saúde

Source: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Subject Terms: 0301 basic medicine, Cell division, Science, 030106 microbiology, Schizosaccharomyces / metabolism, General Physics and Astronomy, Germination, Biology, Microbiology, General Biochemistry, Genetics and Molecular Biology, Article, Transcriptome, Histones, 03 medical and health sciences, Histone H3, Gene Knockout Techniques, Gene expression analysis, Histones / genetics, Germination / physiology, Gene Expression Regulation, Fungal, Schizosaccharomyces, Spore germination, Cell Division / physiology, lcsh:Science, Histones / metabolism, Regulation of gene expression, Multidisciplinary, Gene Expression Profiling, Fungal genetics, Computational Biology, General Chemistry, Spores, Fungal / metabolism, Spores, Fungal, Schizosaccharomyces / genetics, Cell biology, Computational biology and bioinformatics, Gene expression profiling, Cell Division / genetics, 030104 developmental biology, Spores, Fungal / genetics, Dormancy, lcsh:Q

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http://europepmc.org/articles/PMC7062879

18
Conception sur une base rationnelle de peptides de haute affinité inhibant l'histone chaperon ASF1

Authors: Bakail, May, Gaubert, Albane, Andreani, Jessica, Moal, Gwenaëlle, Pinna, Guillaume, Boyarchuk, Ekaterina, Gaillard, Marie-Cécile, Courbeyrette, Régis, Mann, Carl, Thuret, Jean-Yves, Guichard, Berengère, Murciano, Brice, Richet, Nicolas, Poitou, Adeline, Frederic, Claire, Le Du, Marie-Hélène, Agez, Morgane, Roelants, Caroline, Gurard-Levin, Zachary, Almouzni, Geneviève, Cherradi, Nadia, Guérois, Raphaël, Ochsenbein, Françoise

Contributors: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Assemblage moléculaire et intégrité du génome (AMIG), Département Biochimie, Biophysique et Biologie Structurale (B3S), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), PARi (PARI), Département Plateforme (PF I2BC), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Sénescence et stabilité génomique (SEN), Département Biologie des Génomes (DBG), Vaccination Antiparasitaire : Laboratoire de Biologie Cellulaire et Moléculaire (LBCM), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Enveloppe Nucléaire, Télomères et Réparation de l’ADN (INTGEN), Institut de Biologie et de Technologies de Saclay (IBITECS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Invasion mechanisms in angiogenesis and cancer (IMAC), Biologie du Cancer et de l'Infection (BCI ), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut National de la Santé et de la Recherche Médicale (INSERM), Dynamique du noyau [Institut Curie], Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Source: Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2019, 26 (11), pp.1573-1585.e10. ⟨10.1016/j.chembiol.2019.09.002⟩

Subject Terms: Rosetta Design, Drug Design, [SDV]Life Sciences [q-bio], X-Ray Crystallography, Peptide Inhibitor, Epigenetics, MESH: Amino Acid Sequence, Binding Sites, Histones / metabolism, Neoplasms / drug therapy, Transplantation, Homologous, Cell Penetrating Peptide, Chromatin, Protein-Protein Interaction, Protein Binding, Cancer, [SHS]Humanities and Social Sciences

Access URL: https://explore.openaire.eu/search/publication?articleId=od_______212::fe221010a5433fe866ac9dacf0af3f52
https://hal.archives-ouvertes.fr/hal-02385251

19
Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Authors: Simeonova, Iva, Almouzni, Geneviève

Contributors: Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Dynamique du noyau [Institut Curie], Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), ALMOUZNI, Geneviève

Source: Trends in Molecular Medicine
Trends in Molecular Medicine, Elsevier, 2019, 25 (11), pp.933-935. ⟨10.1016/j.molmed.2019.09.003⟩
Trends in Molecular Medicine, 2019, 25 (11), pp.933-935. ⟨10.1016/j.molmed.2019.09.003⟩

Subject Terms: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], chromatin reprogramming, histone H3 dynamics, MESH: Chromatin / metabolism, Histone Chaperones / metabolism, Histones / metabolism, Humans, Neoplasm Metastasis / pathology, Neoplasms / pathology, metastasis, CAF-1

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https://hal.archives-ouvertes.fr/hal-02371000/document

20
Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in H3K4me3 independently from histone H2B monoubiquitination

Authors: Corinne Blugeon, Damarys Loew, Moussa Benhamed, Christophe Bailly, Fredy Barneche, Clara Bourbousse, Nicole Chaumont, Martin Rougée, Sophie Lemoine, David Latrasse, Chris Bowler, Anne-Flore Deton-Cabanillas, Gérald Zabulon, Anne-Sophie Fiorucci, Ammara Mohammad, Bérangère Lombard, Elodie Layat, Lorenzo Concia, Soon Kap Kim, David Stroebel

Contributors: Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie du Développement (LBD), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie du Développement [Paris] (LBD), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Agence Nationale pour la Recherche (ANR) [ANR-11-JSV2-003-01], Investissements d'Avenir program, ANR [ANR-10-LABX-54 MEMOLIFE, ANR-10-IDEX-0001-02 PSL], Universite Paris-Sud Doctoral School in Plant Sciences, Region Ile-de-France, Fondation pour la Recherche Medicale, 'Investissements d'Avenir' program [ANR-10-INBS-09], Fiorucci, Anne-Sophie, Bourbousse, Clara, Barneche, Fredy, Institut de biologie de l'ENS Paris (IBENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie du Développement [IBPS] (LBD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), GenomiqueENS (Genomique ENS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, Gestionnaire, HAL Sorbonne Université 5, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Source: Genome Biology
Genome Biology, BioMed Central, 2019, 20 (1), pp.(2019) 20:100. ⟨10.1186/s13059-019-1705-4⟩
Genome Biology, BioMed Central, 2019, 20 (100), ⟨10.1186/s13059-019-1705-4⟩
Genome biology, vol. 20, no. 1, pp. 100
Genome Biology (20), . (2019)
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Genome Biology, 2019, 20 (100), ⟨10.1186/s13059-019-1705-4⟩

Subject Terms: lcsh:QH426-470, [SDV]Life Sciences [q-bio], Protein subunit, Saccharomyces cerevisiae, Arabidopsis, Histones, 03 medical and health sciences, 0302 clinical medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Histone H2B, Monoubiquitination, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, lcsh:QH301-705.5, Gene, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, biology, Research, Ubiquitination, biology.organism_classification, Arabidopsis/metabolism, Histone Methyltransferases/metabolism, Histones/metabolism, Cell biology, [SDV] Life Sciences [q-bio], lcsh:Genetics, lcsh:Biology (General), Histone methyltransferase, Histone Methyltransferases, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], H3K4me3, 030217 neurology & neurosurgery

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https://doi.org/10.1186/s13059-019-1705-4

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