Authors: Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Kim C; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Fischbach J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Sato K; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Muschiol S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Ehling RA; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Albert J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Peacock TP; Department of Infectious Disease, Imperial College London, London, UK., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden. Electronic address: benjamin.murrell@ki.se.

Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2022 Nov; Vol. 22 (11), pp. 1538-1540. Date of Electronic Publication: 2022 Oct 14.

Publication Type: Letter

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH Terms: Antibodies, Neutralizing* , Antibodies, Viral*, Humans

Authors: Taft JM; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland., Weber CR; Alloy Therapeutics (Switzerland) AG, Basel 4058, Switzerland., Gao B; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland., Ehling RA; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland., Han J; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland., Frei L; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland., Metcalfe SW; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland., Overath MD; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland., Yermanos A; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland; Department of Biology, Institute of Microbiology and Immunology, ETH Zurich, Zurich 8093, Switzerland; Department of Pathology and Immunology, University of Geneva, Geneva 1211, Switzerland., Kelton W; Te Huataki Waiora School of Health, University of Waikato, Hamilton 3240, New Zealand., Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Botnar Research Centre for Child Health, Basel 4058, Switzerland. Electronic address: sai.reddy@ethz.ch.

Source: Cell [Cell] 2022 Oct 13; Vol. 185 (21), pp. 4008-4022.e14. Date of Electronic Publication: 2022 Aug 31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: COVID-19* , SARS-CoV-2*/genetics, Angiotensin-Converting Enzyme 2/*metabolism , Spike Glycoprotein, Coronavirus/*metabolism, Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Humans ; Mutation ; Pandemics ; Protein Binding ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics

SCR Organism: SARS-CoV-2 variants

Authors: Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Kim C; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Fischbach J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Muschiol S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Ehling RA; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Albert J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden., Peacock TP; Department of Infectious Disease, Imperial College London, London, UK., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 65, Sweden. Electronic address: benjamin.murrell@ki.se.

Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2022 Oct; Vol. 22 (10), pp. 1421-1422. Date of Electronic Publication: 2022 Sep 01.

Publication Type: Letter

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH Terms: Antibodies, Neutralizing* , Antibodies, Viral*, Humans

Authors: Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Kim C; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Ehling RA; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Pankow A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Castro Dopico X; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Dyrdak R; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden., Martin DP; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland., Dillner J; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Albert J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address: benjamin.murrell@ki.se.

Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2022 Jun; Vol. 22 (6), pp. 813-820. Date of Electronic Publication: 2022 Mar 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH Terms: COVID-19*/epidemiology , SARS-CoV-2*/genetics, Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Cross-Sectional Studies ; Humans ; Spike Glycoprotein, Coronavirus/genetics

SCR Organism: SARS-CoV-2 variants

Authors: Neumeier D; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Yermanos A; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.; Department of Pathology and Immunology, University of Geneva, 1205 Geneva, Switzerland., Agrafiotis A; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland., Csepregi L; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Chowdhury T; UCB Pharma, Slough SL1 3WE, United Kingdom., Ehling RA; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Kuhn R; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Cotet TS; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Brisset-Di Roberto R; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Di Tacchio M; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Antonialli R; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland., Starkie D; UCB Pharma, Slough SL1 3WE, United Kingdom., Lightwood DJ; UCB Pharma, Slough SL1 3WE, United Kingdom., Oxenius A; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 03; Vol. 119 (18), pp. e2113766119. Date of Electronic Publication: 2022 Apr 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Antigens* , Plasma Cells*, Animals ; Antibodies/genetics ; Antibody Affinity ; Epitopes/genetics ; Mice

Authors: Ehling RA; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Weber CR; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; deepCDR Biologics AG, Basel, Switzerland., Mason DM; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; deepCDR Biologics AG, Basel, Switzerland., Friedensohn S; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; deepCDR Biologics AG, Basel, Switzerland., Wagner B; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Bieberich F; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Kapetanovic E; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Vazquez-Lombardi R; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Di Roberto RB; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Hong KL; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Botnar Research Centre for Child Health, Basel, Switzerland., Wagner C; deepCDR Biologics AG, Basel, Switzerland., Pataia M; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; deepCDR Biologics AG, Basel, Switzerland., Overath MD; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Yermanos A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Botnar Research Centre for Child Health, Basel, Switzerland; Institute of Microbiology and Immunology, Department of Biology, ETH Zurich, Zurich, Switzerland; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Cuny AP; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Swiss Institute of Bioinformatics, Mattenstr. 26, 4058 Basel, Switzerland., Savic M; Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland; Department of Surgery, Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, Basel, Switzerland; Department of Health, Economics and Health Directorate, Canton Basel-Landschaft, Switzerland., Rudolf F; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Swiss Institute of Bioinformatics, Mattenstr. 26, 4058 Basel, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Botnar Research Centre for Child Health, Basel, Switzerland. Electronic address: sai.reddy@ethz.ch.

Source: Cell reports [Cell Rep] 2022 Jan 18; Vol. 38 (3), pp. 110242. Date of Electronic Publication: 2021 Dec 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Antibodies, Neutralizing/*isolation & purification , Plasma Cells/*metabolism , SARS-CoV-2/*immunology , Single-Cell Analysis/*methods, Animals ; Antibodies, Viral/isolation & purification ; COVID-19/immunology ; COVID-19/prevention & control ; Cells, Cultured ; Cohort Studies ; Gene Library ; HEK293 Cells ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Mammals ; Neutralization Tests ; Peptide Library ; Plasma Cells/chemistry

Authors: Bieberich F; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Vazquez-Lombardi R; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Yermanos A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Institute of Microbiology and Immunology, Department of Biology, ETH Zurich, Zurich, Switzerland.; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.; Botnar Research Centre for Child Health, Basel, Switzerland., Ehling RA; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Mason DM; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; deepCDR Biologics AG, Basel, Switzerland., Wagner B; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Kapetanovic E; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Di Roberto RB; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Weber CR; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; deepCDR Biologics AG, Basel, Switzerland., Savic M; Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland.; Department of Surgery, Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, Basel, Switzerland.; Department of Health, Economics and Health Directorate, Canton Basel-Landschaft, Switzerland., Rudolf F; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Botnar Research Centre for Child Health, Basel, Switzerland.

Source: Frontiers in immunology [Front Immunol] 2021 Jul 12; Vol. 12, pp. 701085. Date of Electronic Publication: 2021 Jul 12 (Print Publication: 2021).

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Aging/*immunology , B-Lymphocytes/*immunology , CD4-Positive T-Lymphocytes/*immunology , CD8-Positive T-Lymphocytes/*immunology , COVID-19/*immunology , SARS-CoV-2/*physiology, Adaptive Immunity ; Adult ; Aged ; Cells, Cultured ; Convalescence ; Female ; Humans ; Male ; Middle Aged ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, T-Cell/genetics ; Single-Cell Analysis ; Transcriptome ; Young Adult

Authors: Mason DM; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; deepCDR Biologics, Basel, Switzerland., Friedensohn S; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; deepCDR Biologics, Basel, Switzerland., Weber CR; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; deepCDR Biologics, Basel, Switzerland., Jordi C; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Wagner B; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Meng SM; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Ehling RA; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Bonati L; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Dahinden J; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Gainza P; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Correia BE; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. sai.reddy@ethz.ch.

Source: Nature biomedical engineering [Nat Biomed Eng] 2021 Jun; Vol. 5 (6), pp. 600-612. Date of Electronic Publication: 2021 Apr 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE

MeSH Terms: Deep Learning*, Antigens/*chemistry , Protein Engineering/*methods , Receptor, ErbB-2/*chemistry , Trastuzumab/*chemistry, Amino Acid Sequence ; Animals ; Antibody Affinity ; Antibody Specificity ; Antigens/genetics ; Antigens/immunology ; CRISPR-Cas Systems ; Humans ; Hybridomas/chemistry ; Hybridomas/immunology ; Mutagenesis, Site-Directed ; Protein Binding ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/immunology ; Recombinational DNA Repair ; Sequence Analysis, Protein ; Trastuzumab/genetics ; Trastuzumab/immunology

Authors: Csepregi L; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland., Ehling RA; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland., Wagner B; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

Source: IScience [iScience] 2020 Sep 25; Vol. 23 (9), pp. 101519. Date of Electronic Publication: 2020 Sep 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

Authors: Pesch T; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Bonati L; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Kelton W; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Parola C; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.; Life Science Graduate School, Systems Biology, ETH Zürich, University of Zurich, Zurich, Switzerland., Ehling RA; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Csepregi L; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.; Life Science Graduate School, Microbiology and Immunology, ETH Zürich, University of Zurich, Zurich, Switzerland., Kitamura D; Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

Source: Frontiers in immunology [Front Immunol] 2019 Nov 14; Vol. 10, pp. 2630. Date of Electronic Publication: 2019 Nov 14 (Print Publication: 2019).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: B-Lymphocytes*, Gene Editing/*methods , Protein Engineering/*methods , Receptors, Antigen, B-Cell/*genetics , Receptors, Artificial/*genetics, Animals ; CRISPR-Cas Systems ; Mice ; Receptors, Antigen, B-Cell/immunology ; Receptors, Artificial/immunology