Search Results - "Antigens, Neoplasm -- immunology"

1

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes

Authors: Michael Hebeisen, Minh Ngoc Duong, Efe Erdes, Nathalie Rufer

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 284

Subject Terms: Immunotherapy, Preclinical study, CD8 T cells, NY-ESO-1 tumor antigen, TCR affinity optimization, TCR/CD3 complex, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, chemical and pharmacologic phenomena, Cancer Research, Pharmacology, Oncology, Molecular Medicine, Immunology, Immunology and Allergy, Chemistry, T cell, medicine.anatomical_structure, medicine, Major histocompatibility complex, biology.protein, biology, Cytotoxic T cell, CD3, CD8, Cell biology, Antigen, T-cell receptor, Cell killing, Research Article, T cell activation, Receptor signaling, T cell function, Antigens, Neoplasm/immunology, CD3 Complex/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Line, Tumor, Cytotoxicity, Immunologic, Gene Expression, HLA-A2 Antigen/genetics, HLA-A2 Antigen/immunology, HLA-A2 Antigen/metabolism, Humans, Immunophenotyping, Immunotherapy, Adoptive, Lymphocyte Activation/immunology, Neoplasms/etiology, Neoplasms/metabolism, Neoplasms/therapy, Protein Binding, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/metabolism, Receptors, Chimeric Antigen/genetics, Receptors, Chimeric Antigen/metabolism, Signal Transduction

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http://link.springer.com/article/10.1186/s40425-019-0773-z

2

CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens

Authors: Elise Ramia, Brian Stevenson, Greta Forlani, Michal Bassani-Sternberg, Michael Linnebacher, Elodie Lauret Marie Joseph, Roberto S. Accolla, HuiSong Pak, Justine Michaux, Florian Huber

Source: Molecular & Cellular Proteomics : MCP
Molecular & cellular proteomics, vol. 20, pp. 100032

Subject Terms: Research, Special Issue: Immunopeptidomics, Class II major histocompatibility complex transactivator, Immunopeptidomics, Antigen discovery, Glioblastoma, a.u., arbitrary units, APCs, antigen presenting cells, CIITA, class II major histocompatibility complex transactivator, CTL, cytotoxic T cells, ER, endoplasmic reticulum, ERAAP, ER aminopeptidase-associated with antigen processing, FDR, false discovery rate, GBM, glioblastoma, HCD, higher-energy collision dissociation, HLA, human leukocyte antigen, HLA-I, human leukocyte antigen class I, HLA-II, human leukocyte antigen class II, IFNγ, Interferon gamma, LFQ, label-free quantification, MHC, major histocompatibility complex, PBMCs, peripheral blood mononuclear cells, PSM, peptide spectrum match, SNPs, single nucleotide polymorphisms, SNVs, single nucleotide variants, TAAs, tumor-associated antigens, TAP, transporter-associated with antigen processing, TcR, T cell receptors, TH, T helper cells, WES, whole-exome sequencing, Molecular Biology, Biochemistry, Analytical Chemistry, Cancer research, Epitope, Biology, Antigen-presenting cell, Antigen, Human leukocyte antigen, CIITA, Major histocompatibility complex, biology.protein, T-cell receptor, T cell, medicine.anatomical_structure, medicine, Animals, Antigens, Neoplasm/immunology, Brain Neoplasms/immunology, Cattle, Cell Line, Tumor, Glioblastoma/immunology, Histocompatibility Antigens Class II/immunology, Humans, Nuclear Proteins/genetics, Nuclear Proteins/immunology, Peptides/immunology, Trans-Activators/genetics, Trans-Activators/immunology

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http://europepmc.org/articles/PMC8724627

3

Actively personalized vaccination trial for newly diagnosed glioblastoma

Authors: Regina Mendrzyk, Sonja Dorner, Franziska Hoffgaard, Lukas Bunse, Monika Stieglbauer, Francisco Martínez-Ricarte, Pierre-Yves Dietrich, Valesca Bukur, Alexander Ulges, Bracha Shraibman, Sabrina Kuttruff-Coqui, Toni Weinschenk, Sebastian Kreiter, Per thor Straten, Norbert Hilf, Christian H. Ottensmeier, Hans Skovgaard Poulsen, Jordi Rodon, Juan Sahuquillo, Arbel D. Tadmor, Jorg Ludwig, Bernhard Rossler, Katy J. McCann, Katharina Kiesel, Alexandra Kemmer-Brück, Cécile Gouttefangeas, Nina Pawlowski, Katrin Frenzel, Denis Migliorini, Stefan Stevanovic, Cedrik M. Britten, Claudia Wagner, Dominik Maurer, Hideho Okada, Michael Platten, Jordi Piro, Marij J. P. Welters, Berta Ponsati, Colette Song, Ugur Sahin, Judith R. Kroep, Hans-Georg Rammensee, Ghazaleh Tabatabai, Valérie Dutoit, Elisa Rusch, John C. Castle, Carsten Reinhardt, Oliver Schoor, Harpreet Singh-Jasuja, David Capper, Martin Löwer, Christoph Huber, Jens Fritsche, Sjoerd H. van der Burg, Sandra Heesch, Arie Admon, Marco Skardelly, Wolfgang Wick, Edward W. Green, Miriam Meyer, Evelyna Derhovanessian, Ulrik Lassen, Andreas von Deimling, Manja Idorn

Contributors: Dutoit Vallotton, Valérie, Migliorini, Denis, Dietrich, Pierre-Yves

Source: Nature, Vol. 565, No 7738 (2019) pp. 240-245
Nature, 565(7738), 240

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https://doi.org/10.1038/s41586-018-0810-y

4

Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors

Authors: Lia Gonçalves Pinho, Emmanuel Donnadieu, Vinicius Cotta-de-Almeida, Loïc Dupré

Contributors: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This work was funded by Brazilian National Council for Scientific and Technological Development (CNPq), L.G.P. was supported by grant no. 140718/2019-2 and V.C.A. was supported by grant no. 310329/2019-1. The Coordination for the Improvement of Higher Education Personnel (CAPES), with support from the Program PrInt-Fiocruz-CAPES, the Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), and Mercosur Fund for Structural Convergence (FOCEM, 03/11) provided funding for L.G.P. and V.C.A. E.D. was supported by a funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 667980., European Project: 667980,H2020,H2020-PHC-2015-two-stage,CARAT(2016)

Source: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2020, 108 (4), pp.1067-1079. ⟨10.1002/JLB.1MR0520-746R⟩

Subject Terms: T cell trafficking, cancer immunotherapy, chimeric antigen receptor engineering, extracellular matrix, motility, tumor microenvironment, MESH: Antigens, Neoplasm / immunology, MESH: Cell Movement / immunology, MESH: T-Lymphocytes* / immunology, MESH: T-Lymphocytes* / pathology, MESH: Tumor Microenvironment / immunology, MESH: Humans, MESH: Immunotherapy, Adoptive, MESH: Neoplasms* / immunology, MESH: Neoplasms* / pathology, MESH: Neoplasms* / therapy, MESH: Receptors, Chimeric Antigen / immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Review, XLIV Congress of the Brazilian Society of Immunology, Guest Editors: João P.B. Viola, Lis Antonelli, Martin Bonamino, Jose Alves Filho, and Helder Nakaya, Reviews, Cell Biology, Immunology, Immunology and Allergy, Cancer research, Biology, Immune checkpoint, Tumor microenvironment, T cell, medicine.anatomical_structure, medicine, Cancer cell, Chimeric antigen receptor, Cytotoxic T cell, Antibody, biology.protein, Cancer immunotherapy, medicine.medical_treatment

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https://ut3-toulouseinp.hal.science/hal-03536616

5

Prérequis pour une production académique des cellules CART conforme aux bonnes pratiques pharmaceutiques (BPF). Recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)

Authors: Deschamps, Marina, Decot, Véronique, Giverne, Camille, Pinturaud, Marine, Vaissié, Alix, Parquet, Nathalie, Olivero, Sylvain, Mamez, Anne-Claire, Bay, Jacques-Olivier, Yakoub-Agha, Ibrahim, Ferrand, Christophe

Source: Bulletin du cancer, Vol. 107, No 1S (2020) pp. S85-S93

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https://archive-ouverte.unige.ch/unige:154738

6

Immuno-oncology-101

Authors: Soizic Garaud, Cinzia Solinas, Christos Sotiriou, Bertrand Allard, Marleen Kok, Floriane Dupont, Sandrine Aspeslagh, Bertrand Routy, Laurence Buisseret, John Stagg

Contributors: Medical Oncology, Laboratory of Molecular and Medical Oncology, Faculty of Psychology and Educational Sciences, Faculty of Physical Education and Physical Therapy

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https://biblio.vub.ac.be/vubir/(38f19da3-c74f-4112-8f4d-2c903f3ed4fd).html

7

Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients

Authors: Daniel E. Speiser, Laurène Cagnon, Alexandre Huber, Petra Baumgaertner, Hélène Maby-El Hajjami, Nathalie Rufer, Emanuela M. Iancu, Samia Abed Maillard, Philippe O. Gannon

Source: Clinical cancer research, vol. 23, no. 13, pp. 3285-3296

Subject Terms: Cancer Research, Oncology, Melanoma, medicine.disease, medicine, Effector, Ex vivo, T-cell receptor, Biology, Adoptive cell transfer, CD8, Immunology, Cytotoxic T cell, Stem cell, Adoptive Transfer, Antigens, Neoplasm/immunology, Antigens, Neoplasm/therapeutic use, CD8-Positive T-Lymphocytes/drug effects, CD8-Positive T-Lymphocytes/immunology, Cancer Vaccines/immunology, Cancer Vaccines/therapeutic use, Cell Differentiation/drug effects, Cell Differentiation/immunology, Freund's Adjuvant/immunology, Freund's Adjuvant/therapeutic use, HLA-A2 Antigen/immunology, Humans, Immunologic Memory/drug effects, Lipids/immunology, Lipids/therapeutic use, Lymphocyte Activation/drug effects, Lymphocyte Activation/immunology, MART-1 Antigen/immunology, MART-1 Antigen/therapeutic use, Melanoma/immunology, Melanoma/pathology, Melanoma/therapy, Stem Cells/drug effects, Stem Cells/immunology, T-Lymphocytes/immunology

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https://doi.org/10.1158/1078-0432.ccr-16-1708

8

Quelle place pour les associations de l’immunothérapie à la chimiothérapie ou de plusieurs immunothérapies ?

Authors: Gaëlle Douchet, Sandrine Aspeslagh

Contributors: Medische Oncologie

Source: Bulletin du Cancer. 104:485-493

Access URL: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6887baba0df89def5e8826b1edaa5c3d
https://doi.org/10.1016/j.bulcan.2017.03.008

9

CARs in the Lead Against Multiple Myeloma

Authors: Felipe Bedoya, Maria Ormhøj, Matthew J. Frigault, Marcela V. Maus

Source: Ormhøj, M, Bedoya, F, Frigault, M J & Maus, M V 2017, ' CARs in the Lead Against Multiple Myeloma ', Current Hematologic Malignancy Reports, vol. 12, no. 2, pp. 119–125 . https://doi.org/10.1007/s11899-017-0373-2

Subject Terms: Cancer Research, Oncology, Hematology, Antigen, medicine.medical_specialty, medicine, T cell, medicine.anatomical_structure, Myeloma protein, Internal medicine, Multiple myeloma, medicine.disease, business.industry, business, Immunology, Cancer research, CD19, biology.protein, biology, Chimeric antigen receptor, Stem cell, hemic and lymphatic diseases, immune system diseases, Adoptive T cell therapy, B cell maturation antigen, Clinical trials, Recombinant Fusion Proteins/genetics, Antigens, Neoplasm/immunology, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes/immunology, Humans, Multiple Myeloma/immunology, Immunotherapy, Adoptive/adverse effects, Treatment Outcome, Clinical Trials as Topic, T-Cell Antigen Receptor Specificity/immunology, Article

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https://doi.org/10.1007/s11899-017-0373-2

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10

Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

Source: Nature communications, vol. 9, no. 1, pp. 1092
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications

Subject Terms: Antigens, Neoplasm/immunology, CD8-Positive T-Lymphocytes/metabolism, Epitopes, T-Lymphocyte/immunology, Epitopes, T-Lymphocyte/metabolism, Female, Humans, Immunotherapy/methods, Lymphocytes, Tumor-Infiltrating/metabolism, Ovarian Neoplasms/immunology, Ovarian Neoplasms/metabolism, Ovarian Neoplasms/therapy, Receptors, Antigen, T-Cell/genetics, chemical and pharmacologic phenomena, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Antigen, CD8, Epitope, Cancer immunotherapy, medicine.medical_treatment, medicine, Cytotoxic T cell, Avidity, Cancer research, Immunotherapy, Ovarian cancer, medicine.disease, Biology, hemic and immune systems, Science, endocrine system diseases, female genital diseases and pregnancy complications, lcsh:Science, lcsh:Q, Article

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https://serval.unil.ch/notice/serval:BIB_10AE95ADCEE8

11

Functional TCR Retrieval from Single Antigen-Specific Human T Cells Reveals Multiple Novel Epitopes

Authors: Cedrik M. Britten, Abdo Konur, Claudia Paret, Andrea Breitkreuz, Sebastian Kreiter, Karl Dhaene, Tana Omokoko, Özlem Türeci, Lisa Hebich, Sebastian Attig, Petra Simon, Ugur Sahin

Contributors: Supporting clinical sciences, Experimental Pathology

Source: Cancer Immunology Research. 2:1230-1244

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https://doi.org/10.1158/2326-6066.cir-14-0108

12

Immune biomarkers for predicting response to adoptive cell transfer as cancer treatment

Authors: van Belzen, Ianthe A E M, Kesmir, Can, Sub Theoretical Biology, Theoretical Biology and Bioinformatics

Source: Immunogenetics, 71(2), 71. Springer Verlag
Immunogenetics

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13

KLINIČKA IMUNOTERAPIJA RAKA BLOKADOM MOLEKULARNIH INTERAKCIJA NEGATIVNE POVRATNE SPREGE

Authors: ANTONIO JURETIĆ, MARTINA BAŠIĆ-KORETIĆ

Source: Liječnički vjesnik
Volume 139
Issue 5-6

Subject Terms: Tumori – imunologija, liječenje, Imunoterapija – metode, Tumorski antigeni – imunologija, t-limfociti – imunologija, Limfocitna aktivacija – imunologija, Kontrolne točke staničnog ciklusa, Monoklonska protutijela – imunologija, terapijska primjena, CTLA-4 – antagonisti i inhibitori, PD-1 receptor – antagonisti i inhibitori, PD-l1 - antagonisti i inhibitori, Imunološki nadzor, Neoplasms – immunology, therapy, Immunotherapy – methods, Antigens, neoplasm – immunology, t-lymphocytes – immunology, Lymphocyte activation – immunology, Cell cycle checkpoints, Antibodies, monoclonal – immunology, therapeutic use, CTLA-4 antigen – antagonists and inhibitors, Programmed cell death 1 receptor – antagonists and inhibitors, Antigens, CD274 – antagonists and inhibitors, Immunologic surveillance

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https://hrcak.srce.hr/187276

14

Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy

Authors: Nicolas Page, Florian Kreppel, Matthias Kreuzaler, Sanjiv A. Luther, Alfred Zippelius, Daniel D. Pinschewer, Min Lu, Philipp Müller, Stéphanie Favre, Doron Merkler, Stephanie Darbre, Weldy V. Bonilla, Sandra M. Kallert, Mario Kreutzfeldt, Max Löhning

Source: Nature Communications, Vol. 8 (2017) P. 15327
Nature communications, vol. 8, pp. 15327
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications

Subject Terms: ddc:616.07, Alarmins/immunology, Animals, Antigens, Neoplasm/immunology, Cancer Vaccines/immunology, Cancer Vaccines/therapeutic use, Cell Line, Tumor, Dendritic Cells/immunology, Gene Expression Profiling, Genetic Engineering, Genetic Vectors/genetics, Genetic Vectors/immunology, Genetic Vectors/therapeutic use, HEK293 Cells, Humans, Immunotherapy/methods, Interleukin-33/genetics, Interleukin-33/immunology, Lymphocyte Activation/immunology, Lymphocytic choriomeningitis virus/genetics, Mesocricetus, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Neoplasms/immunology, Neoplasms/therapy, T-Lymphocytes, Cytotoxic/immunology, Tumor Microenvironment/immunology, Vaccines, Live, Unattenuated/immunology, Virus Replication/genetics, Virus Replication/immunology, Xenograft Model Antitumor Assays, Science, Article, Live attenuated vaccines, Lymphocyte activation, Tumour vaccines, Viral vectors, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Cytotoxic T cell, CTL, Immunology, Cancer immunotherapy, medicine.medical_treatment, medicine, Immunotherapy, Cancer research, Priming (immunology), Viral vector, Lymphocytic choriomeningitis, medicine.disease, Effector T-Lymphocyte, Biology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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https://archive-ouverte.unige.ch/unige:98397

15

[Paraneoplastic neurological syndromes: an update]

Authors: Zekeridou, Anastasia, Iancu Ferfoglia, Ruxandra, Du Pasquier, Renaud Alfred Robert, Lalive d'Epinay, Patrice

Source: Revue médicale suisse, Vol. 12, No 516 (2016) pp. 832-839

Subject Terms: ddc:616.8, Antigens, Neoplasm/immunology, Autoantibodies/immunology, Humans, Immunomodulation, Immunotherapy/methods, Neoplasms/complications/immunology, Paraneoplastic Syndromes, Nervous System/immunology/therapy

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https://archive-ouverte.unige.ch/unige:89952

16

Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells

Authors: Daniel E. Speiser, Camilla Jandus, Maurice Matter, Immanuel F. Luescher, Jean-Paul Rivals, Tanja Lövgren, Gregoire Berthod, Philippe Guillaume, Laurent Derré, Lukas Baitsch, Olivier Michielin, Nathalie Rufer, Petra Baumgaertner

Source: International journal of cancer. Journal international du cancer
International Journal of Cancer. Journal International Du Cancer, vol. 130, no. 11, pp. 2607-2617