Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation

by Solano, Silvia, Segura Ruiz, Álvaro, León Montero, Guillermo, Gutiérrez, José María, Burnouf, Thierry
Published 2017

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms

by León Montero, Guillermo, Herrera Vega, María, Segura Ruiz, Álvaro, Villalta Arrieta, Mauren, Vargas Arroyo, Mariángela, Gutiérrez, José María
Published 2017

Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método

by Segura Ruiz, Álvaro, Vargas Arroyo, Mariángela, León Montero, Guillermo, Angulo Ugalde, Yamileth, Villalta Arrieta, Mauren, Herrera Vega, María
Published 2020

Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step

by Vargas Arroyo, Mariángela, Segura Ruiz, Álvaro, Villalta Arrieta, Mauren, Herrera Vega, María, Gutiérrez, José María, León Montero, Guillermo
Published 2017

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice

by Rivel Piedra, Mario, Solano Centeno, Daniela, Herrera Vega, María, Vargas Arroyo, Mariángela, Villalta Arrieta, Mauren, Segura Ruiz, Álvaro
Published 2017

Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs

by Herrera Vega, María, León Montero, Guillermo, Segura Ruiz, Álvaro, Meneses, Fabricio, Lomonte, Bruno, Chippaux, Jean Philippe, Gutiérrez, José María
Published 2016

Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows

by Estrada Umaña, Ricardo, Herrera Vega, María, Segura Ruiz, Álvaro, Araya, Javier, Boschini Figueroa, Carlos, Gutiérrez, José María, León Montero, Guillermo
Published 2016

Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature

by Segura Ruiz, Álvaro, Vargas Arroyo, Mariángela, Herrera Vega, María, González, Esteban, Solano Trejos, María Gabriela, Gutiérrez, José María, León Montero, Guillermo
Published 2016

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

by Vargas Arroyo, Mariángela, Segura Ruiz, Álvaro, Herrera Vega, María, Villalta Arrieta, Mauren, Angulo Ugalde, Yamileth, Gutiérrez, José María, León Montero, Guillermo
Published 2017

Neutralization of Bothrops mattogrossensis snake venom from Bolivia: Experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation

by Fernández, Gil Patrick, Segura Ruiz, Álvaro, Herrera Vega, María, Velasco, Williams, Solano Trejos, María Gabriela, Gutiérrez, José María, León Montero, Guillermo
Published 2016

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom

by Solano Trejos, María Gabriela, Segura Ruiz, Álvaro, Herrera Vega, María, Gómez Argüello, Aarón, Villalta Arrieta, Mauren, Gutiérrez, José María, León Montero, Guillermo
Published 2016

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica

by Laines, Johana, Segura Ruiz, Álvaro, Villalta Arrieta, Mauren, Herrera Vega, María, Vargas Arroyo, Mariángela, Alvarez, Gladys, Gutiérrez, José María, León Montero, Guillermo
Published 2017

Immune Response Towards Snake Venoms

by León Montero, Guillermo, Sánchez Céspedes, Laura Vanessa, Hernández, Andrés, Villalta Arrieta, Mauren, Herrera Vega, María, Segura Ruiz, Álvaro, Estrada Umaña, Ricardo, Gutiérrez, José María
Published 2017

Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom

by Arroyo Portilla, Cynthia, Solano Rojas, Sergio, Herrera Vega, María, Segura Ruiz, Álvaro, Estrada Umaña, Ricardo, Vargas Arroyo, Mariángela, Villalta Arrieta, Mauren, León Montero, Guillermo
Published 2017

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus

by Sánchez Brenes, Andrés, Herrera Vega, María, Villalta Arrieta, Mauren, Solano Centeno, Daniela, Segura Ruiz, Álvaro, Lomonte, Bruno, Gutiérrez, José María, León Montero, Guillermo, Vargas Arroyo, Mariángela
Published 2019

Industrial Production and Quality Control of Snake Antivenoms

by León Montero, Guillermo, Segura Ruiz, Álvaro, Gómez Argüello, Aarón, Hernández Bolaños, Andrés, Navarro Arias, Diego, Villalta Arrieta, Mauren, Vargas Arroyo, Mariángela, Herrera Vega, María, Gutiérrez, José María
Published 2019

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms

by Sánchez Brenes, Andrés, Coto Porras, Jorge, Segura Ruiz, Álvaro, Vargas Arroyo, Mariángela, Solano Trejos, María Gabriela, Herrera Vega, María, Villalta Arrieta, Mauren, Estrada Umaña, Ricardo, Gutiérrez, José María
Published 2017

Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of pol...

by Dos Santos, María Cristina, Arroyo Portilla, Cynthia, Solano Rojas, Sergio, Herrera Vega, María, Villalta Arrieta, Mauren, Segura Ruiz, Álvaro, Estrada Umaña, Ricardo, Gutiérrez, José María, León Montero, Guillermo
Published 2017

Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)

by Valverde Barrantes, Juan Manuel, Rodríguez Mora, Karina María, Villalta Arrieta, Mauren, Herrera Vega, María, Segura Ruiz, Álvaro, Vargas Arroyo, Mariángela, Montero Villalobos, Mavis Lili, Gutiérrez, José María, León Montero, Guillermo
Published 2022

Role of the animal model on the pharmacokinetics of equine-derived antivenoms

by Rojas Araya, Alicia, Vargas Arroyo, Mariángela, Ramírez Arguedas, Nils Antonio, Estrada Umaña, Ricardo, Segura Ruiz, Álvaro, Herrera Vega, María, Villalta Arrieta, Mauren, Gómez Argüello, Aarón, Gutiérrez, José María, León Montero, Guillermo
Published 2017